The department focusses on a wide array of research topics, reflecting the diversity of modern biotechnology. The four thrust areas of Research (M.S. and Ph. D.), are listed here:
I. Biological Sciences
Molecular oncology • Cancer immunotherapy • Anti-cancer nutraceuticals • HIV pathogenesis • Stem cell biology • Biomarkers for cardiovascular disease • Gene regulation in hypertension • Molecular and cellular basis of cardiovascular complications • Structure- function relationship of ion channels • Ion channels associated with ischemic heart diseases and stroke • Nanoparticles • Nanobiotechnology of food packaging • Nucleolar GTPases and cell proliferation • Pattern formation in cellular slime moulds • Plant developmental genetics • Recombinant Enzymes • Biofuel cells • Biorefinery
II. Biological Engineering
Industrial metabolite production • Metabolic engineering • Biopolymers • Biocompatibility • Biodegradation of polymers • Tissue engineering • Caffeine degradation • Membrane biochemistry • Plant cell bioprocessing • Phytoremediation • Biofuels • Process chromatography • Reactive species in biological systems
III. Computational Biology
Protein structure, folding and function • Protein dynamics • Computational analysis of protein folding and stability • Binding specificity of protein complexes • Green chemistry • Structure-based drug design and discovery • Comparative genomics • Computational modelling of neurodegenerative disorders • Computational systems biology • Development and analysis of databases and tools • Computational biophysics • GPGPU computing for systems biology
IV. Chemical Biology
‘Green’ biocatalytic methods for organic transformations • Delivery of siRNAs • Fragment-based drug design • Novel inhibitors against HDACs and HMT • Asymmetric catalysis
Entrance exams will happen in four separate streams covering various areas: Biological Sciences will involve aspects of Biochemistry, Molecular Biology, Cell Biology, etc. Biological Engineering will involve aspects of Biochemical engineering, Downstream Processing, etc. Chemical Sciences will test on aspects of Organic, Inorganic and Physical Chemistry. Computational Biology will test on aspects of mathematics, bioinformatics and computing.
Candidates will be short-listed for the interview based on performance in the screening test(s). Final decision on selection will be made based on overall performance.
Previously available research topics:
Guide Allotment Procedure
The procedure followed for guide allotment for PhD, PhD in Biomedical Devices and MS (by research) are listed here.PDF.
Department of Biotechnology
Indian Institute of Technology Madras
Chennai – 600 036