Research Interests
The primary objective of my research team is to elucidate molecular
and cellular mechanisms of normal and aberrant function of blood vessels under physiological and
patho-physiological conditions respectively. The key areas we focus on are endothelial dysfunction,
atherosclerosis and edema. In order to obtain a holistic picture on these issues we would subscribe
to the following approaches:
1) High through put screening for identification of changes in gene expression from clinical samples.
2) In vitro tissue culture experiments to identify signaling intermediates altered under pathological
settings. For this we would employ primary cultures of vascular smooth muscle cells (VSMCs), and human
umbilical vein endothelial cells (HUVECs).
3) Validation of in vitro data through in vivo animal experiments.
4) Use of viral vector based gene delivery systems to rectify the faulty functioning of the signaling intermediates.
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