Research Interests

1. Drug Design and QSAR/QSPR of Anti-inflammatory, Anti-cancer and Antiplatelet aggregartion molecules.
*    QSAR and Natural products
*    Enzyme-Ligand Binding studies
*    Drug delivery. Modelling of drug and delivery systems such as polymer and surfactant-Interactions

2. Biodegradation of Polymers (PU/PC/LDPE/HDPE/Nylon)
*    Aerobic/Anaerobic Biodegradation of Sugar / Distillery effluents
*    Decolourisation
*    Use of Marine microorganims and white rot fungii for biodegradation

3. Modelling of Bioreactors. Neural Networks

4. Modelling and pattern recognition in Biomedical applications - study of EEG and ECG patterns

5. Reaction mechanism studies of homogeneous, heterogeneous and enzyme catalysed reactions

6. Statistical process control and Six-Sigma

7. Scale-up of Chemical processes such as Rubber Chemicals, Plastics, Specialty Chemicals, Explosives, Pharmaceuticals and Paints

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Educational Background

*    PhD: Process Control, University of Aston, Birmingham, UK

*    M Tech: Process control, Chemical engineering, I.I.T. Madras

*    B Tech: Chemical engineering , I.I.T. Madras

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Career Profile

*    Associate Professor, Dept of Biotechnology, IIT Madras, Chennai (15th Apr 2004-)

*    Faculty at Centre for Biotechnology, Anna University, Chennai (July 2003-Mar 2004)

*    Program Leader, Chemical engineering modelling group, GE India Technology centre, Bangalore (Jan 2000 - Jun, 2003 )

*    Group Manager, ICI India R&T centre , Bombay (Sept, 1989-Dec, 1999)

*    Research Fellow, Texas A&M University, USA (Sept 1988- Sept 89)

*    Senior Scientist, ICI India R&T centre , Bombay (Sept, 1983-Dec, 1988)

*    Post Doctoral Fellow, University of Cambridge, UK (1980-83)

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Publications

1. Mukesh Doble, S.Karthikeyan, P.A.Padmaswar, K.G.Akamanchi, QSAR studies of Paeonol analogues for inhibition of platelet aggregation, Bioorganic & Medicinal Chemistry (in press)

2. S Sunitha and Mukesh, Comparison of Aerobic and Anaerobic processes, Indian Chemical Engineers (Jan-March, 2005) 24

3. Mukesh Doble, Six Sigma and chemical process safety, International. J. Six Sigma and Competitive Advantage, Vol. 1, No. 2, 2005 229

4. M. Doble, Understand the myths surrounding Six Sigma, Hydrocarbon Processing, March 2005, 1

5. V R S Kishore, Ravi Kishore, D Mukesh, Neural network modelling of Hydontoinase production, International conference on Intelligent sensing and information processing, 4-7 Jan 2004, Chennai, India, Proceedings 456

6. D. Mukesh, Six Sigma for the Chemical Process industry, Chemical Industry Digest, Nov-Dec 2003, 103

7. Prem Raj, Mukesh D (2004) Biodegradation of polymers, INDIAN J OF BIOTECHNOLOGY, Vol 4 (2005) 186-193

8. Mukesh D (2003) Putting Six-Sigma processes to work, CHEMICAL ENGINEERING, Nov 62-67.

9. Mukesh D, Scale up of chemical reaction, CHEMICAL ENGINEERING, Jan 48.

10. Tawde SR, Mukesh D, Yakmi JV (2002) Redox behaviour of polyaniline as influenced by aromatic sulphonate anions:cyclic voltammetry and molecular modeling, Synthetic metals, 125, 401.

11. Bhaduri Sumit, Kumar Lahiri Goutam, Mukesh D, Paul Himadri, Sharma Krishna (2001) Kinetic investigations on the redox reactions of platinum carbonyl clusters with dihydrogen and acid, ORGANOMETALLICS, 20(15), 3329-3336.

12. Bhaduri S, Mukesh D, Pagni RM, Homogeneous catalysis (2001) Mechanisms and industrial applications, JOURNAL OF CHEMICAL EDUCATION, 78(7), 882.

13. Mukesh D (2001) An analogy between fractional distillation and fit and unfit persons, J OF CHEMICAL EDUCATION, Feb, 211.

14. Mukesh D (2000) Statistical process control-process capability& product spec, CHEMICAL ENGINEERING, Mar, 82.

15. Gandhi NN, Patil NS, Sawant SB, Joshi JB, Wangikar PP, Mukesh D, Lipase catalyzed esterification, CATAL REV-SCI & ENGN, 42(4), 439.

16. Bhaduri S, Lahari GK, Munshi P, Mukesh D (2000) CATALYSIS LETTERS, 65, 1.

17. Tawde SR, Mukesh D, Yakhmi JV, Manohar C (1999) Dye adsorption on self assembled silane monolayers:optical adsorption & modeling, J. OF MATERIAL CHEM, 9, 1847.

18. Mukesh D (1999) Succeed at process developement, CHEMICAL ENGG PROGRESS, 95(2), 23.

19. Joshi MV, Vaidya S, Pandey R, Mukesh D (1999) Catalytic cycle during heteropolyacid catalyzed transfer hydrogenation reaction, J of Catalysis, 183 (1999) 102.

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Other Publications 1998 and Before

20. D.Mukesh, S.Jadhav, A.A.Banerji, K.Thakkar, H.S.Bevinakatti, Lipase catalysed esterification reactions-Experimental and modelling studies, J Chem Techn & Biotechn, 69 (1997) 17.

21. D.Mukesh, M.V.Joshi, D.V.Durve, K.N.Phalke, Scaleup studies on styrene butylmethacrylate copolymerization reaction, Organic Process res & dev, 1(2) (1997) 124.

22. N.N.Gandhi, S.B.Sawant, J.B.Joshi, D.Mukesh, Deactivation of immobilised lipozyme-effect of butanol and water content, Chemical engng J, 65 (1997) 159

23. D.Mukesh, R.Y.Nadkar, Neural network modelling of human EEG patterns, Current Sci, 72 (4), (1997) 261.

24. M.V.Joshi, D.Mukesh, Transfer hydrogenation of nitocompounds with heteropoly acids, J of Catalysis, 168 (1997) 273

25. G.Sudesh kumar, A.Ghograe, D.Mukesh, Synthesis of Alkyds involving regioselective lipase catalysed transesterifications in organic media, J of Appl Polymer Sci, 63 (1997) 35.

26. S.Bhaduri, A.Chatterjee, S.Pal, S.Tawde, D.Mukesh, Molecular orbital calculations on Hru3(CO)9(PhNCO) and related clusters, Proc (Chemical Sci) Indian Acad of Sci, 108(5), (1996) 495.

27.D.Mukesh, Include HAZOP analysis in process developement, in Practical engng perspectives : Plant safety, (1996) 100

28. D.Mukesh, Hate statistics? Try neural network, Chemical engineering, (Mar, 1997) 96.

29. N.N.Gandhi, S.B.Sawant, J.B.Joshi, D.Mukesh, Lipozyme deactivation by butanol and temperature, Enzyme & Microbial Techn, 17 (1995) 373

30. M.V.Joshi, D.Mukesh Scaleup of styrene butylmethacrylate copolymerization reaction, Chemical engng & Techn, 19 1996) 65

31. D.Mukesh, Application of neural computing for process chemists: I. Introduction to neural network and II. Examples., J of Chemical education, (May and June 1996) 431 & 519.

32. D.Mukesh, Improve your chances for successful process development skills, Chemical engineering progress (Feb, 1996) 110.

33. M.V.Joshi, D.Mukesh, Heteropolyacid catalysed transfer hydrogenation of nitro compounds, in Catalysis:Modern trends, Norossa Publishing (1995) 292.

34. M.V.Joshi, C.S.Narasimhan, D.Mukesh, Shape selective diacetate formation of aldehydes using H-ZSM-5, Catalysis Present & Future, Wiley eastern ltd (1995) 38.

35. M.V.Joshi, C.S.Narasimhan, D.Mukesh, H-ZSM-5 catalyzed shape selective formation of diacetates, ZEOLITES, 15 (1995) 597.

36. D.Mukesh, Mass transfer and car driving, J of Chemical Education, 72 (1995) 436

37. D.Mukesh, A.A.Banerji, H.S.Bevinakatti, Findings on transesterification of vegetable oils catalysed by lipase in tubular/packed systems, Indian Chem. Engr., 36(4)(1994)193.

38.D.Mukesh, HAZOP tools for process development, Chem. Engng. Prog., 99(6) (1994) 72

39. D.Mukesh, Molecular graphics of polymer, Polymer Sci & recent adv., Allied publ (1994) 719.

40. S.Bhaduri, K.Sharma, D.Mukesh, Some aspects of the chemistry of platinum carbonyl clusters, Proc. Indian Acad. Sci (Chemical Sci.), 106(3), (1994) 713.

41.D.Mukesh, R.S.Iyer, J.S.Wagh, A.A.Mokashi, A.A.Banerji, R.V.Newadkar, H.S.Bevinakatti, Lipase catalysed transesterification of castor oil, Biotech. Letters, 15(3), (1993) 251.

42. D.Mukesh, A.A.Banerji, R.V.Newadkar, H.S.Bevinakatti, Lipase catalysed transesterification of vegetable oils - A comparitive study in batch and tubular reactors, Biotech. Letters, 15(1), (1993), 77.

43.D.Mukesh, Modelling of Belousov-Zhabotinskii reaction on a surface, Chaos, Solitons and Fractals, 3 (1993) 285.

44.M.V.Joshi, D.Mukesh, Experimental and modelling studies on styrene butyl methacrylate copolymerization reaction, J of Applied Polym. Sci., 50(1), (1993) 75.

45. D.Mukesh, Molecular modelling and graphics of polymers, Current Sci., 65(9) (1993) 672.

46. D.Mukesh, S.Jadhav, D.Sheth, A.A.Banerji, R.V.Newadkar, H.S.Bevinakatti, Lipase catalysed esterification in a tubular reactor, Biotech. Techn., 7(8), (1993), 569.

47. D.Mukesh, B.N.Roy, Role of process studies in industrial chemicals, Res & Industry, 38( Dec,1993)219.

48. D.Mukesh, A.A.Banerji, R.Newadkar, H.S.Bevinakatti, Mathematical modelling of enzymatic hydrolysis of vegetable oils by butanol, Biocatalysis, 8 (1993) 191.

49. D.Mukesh, D.Sheth, A.Mokashi, J.Wagh, J.M.Tilak, A.A.Banerji, K.R.Thakkar, Lipase catalysed esterification of isosorbide and sorbitol, Biotech. Letters, 15(12), (1993) 1243.

50. M.V.Joshi, D.Mukesh, Experimental and modelling studies on styrene butyl methacrylate copolmerization reaction, J of Applied Polymer Sci., 50(1), (1993) 75.

51. V.Swayambunathan, D.Mukesh, S.Krishnan, S.V.Chikale, P.K.Ghosh, Concentrated emulsions 4. Freeze fracture SEM studies of chemically generated voids, J Colloid and Interface sci., 156 (1993) 66.

52. S.Bhaduri, K.Sharma, D.Mukesh, Transfer hydrogenation of ketones with H3Ru4(CO)12 as the pre-catalyst, J.Chem.Soc. Dalton Transaction, (1993) 1191.

53. D.Mukesh, K.Srinivasan, Modelling of paint film curing by fractals, Current Science, 62(5) (1992), 414.

54. D.Mukesh, R.Saluke, A.A.Banerji, H.S.Bevinakatti, Mathematical modelling of lipase catalysed transesterification reactions, BioCatalysis, 6 (1992) 151 .

55. D.Mukesh, Oscillations during carbon monoxide oxidation: a Monte-Carlo simulation, J of Catalysis, 133 (1992) 153.

56. S.Bhaduri, K.Sharma, D.Mukesh, Tetra-nuclear ruthenium cluster catalysed transfer hydrogenation of a,b- substituted aldehydes, J.Chem.Soc. Dalton Transaction,(1992), 77.

57. D.Mukesh, A.K.Das, P.K.Ghosh, Concentrated Emulsions 2. Effect of interdroplet film thickness on droplet size and distortion in mono- and bi- disperse FCC packings, Langmuir,8,(1992)807.

58. A.K.Das, D.Mukesh, V.Swayambunathan, D.D.Kothkar, P.K.Ghosh, Concentrated Emulsions 3. Studies on the influence of continuous phase viscosity, volume fraction, droplet size and temperature on emulsion viscosity, Langmuir, 8,(1992)2427.

59. S.Bhaduri, V.S.Dharshane, K.Sharma, D.Mukesh, carbonyl cluster derived polystyrene supported platinum for asymmetric hydrogenation of a-ketoesters, J Chem. Soc. Chem. Commn., (1992), 1738.

60. D.Mukesh, K.Srinivasan, A.Ghogre, A fractal approach to curing reaction on a surface, in Polymer Sciences : Contemporary themes, Volume I (Ed: S.Sivaram), Tata Mcgraw Hill publishing co. Ltd., New Delhi (1991)p 104.

61. H.S.Bevinakatti, A.A.Banerji, R.V.Newadkar, D.Mukesh, Mathematical modelling of lipase catalysed resolution of O-acetyl and O-formyl derivatives of secondary alcohols, Biocatalysis, 5(2) (1991) 99.

62. D.Mukesh,A.A.Banarjee,Heterogeneous catalytic transfer hydrogenation reactions of 4-nitro diphenyl amine, Applied Catalysis, 59(1990) 1.

63. D.B.Bukur,D.Mukesh,S.A.Patel,Promoter Effects on Precipitated Iron Catalyst for Fischer-Tropsch Synthesis,I. & E. C. Research, 29 (1990)194.

64. D.B.Bukur, X.Lang, D.Mukesh, W.H.Zimmerman, M.P.Rosynek, C.Li, Binder / Support Effects on the activity and selectivity of iron catalysts in the Fischer-Tropsch synthesis,I. & E. C. Research, 29 (1990)1588.

65. S.Bhaduri,D.Mukesh,K.Sharma, Autocatalysis and free radical mechanism in a ruthenium cluster catalysed hydrogen transfer reaction, J Chem. Soc. Chem. Commn., (1990),1506.

66. D.Mukesh,S.Bhaduri,V.Khanwalkar,Homogeneous catalysed autoxidation of car-3-ene, a-pinene and tetralin, Chemical Engng. Journal,41(1989)67

67.D.Mukesh,C.S.Narasimhan,K.Ramnarayan,V.M.Deshpande,Isomerization of methyl linoleate on ruthenium II alkoxide complex- mathematical modeling,I. & E. C. Research, 28(1989)1148.

68. D.Mukesh,S.Bhaduri,Homogeneous catalysed autoxidation of car-3-ene,Research & Industry,34(Dec.1989)263.

69. D.Mukesh, S.Bhaduri, V.Khanwalkar,Homogeneous catalyzed autoxidation of car-3-ene,Chemical Engng. journal,38(1988)153

70. D.Mukesh, C.S.Narasimhan, V.M.Deshpande, K.Ramnarayanan,Isomerization of methyl linoleate on supported ruthenium- nickel catalyst, I. & E. C. Research, 27 (1988)409

71. S.Bhaduri,V.Khanwalkar,D.Mukesh,Metal complex catalysed autoxidation:a correlation between the oxidation potentials of the complexes and rate parameters determined by kinetic modelling

72. A.A.Banarjee,D.Mukesh,Heterogeneous catalytic transfer hydrogenation of 4-nitro diphenyl amine, J.C.S.(chemical communications), (1988) 1275

73. P.Y.Shrotri, A.Mokashi, D.Mukesh,Retention time predictions in programmed temperature gas- solid and gas-liquid chromatography, J of Chromatography, 387 (Jan 30, 1987) 399

74. D.Mukesh,K.S.Gopalakrishnan,Performance of a large packed recirculating reactor for homogeneous catalytic oxidation of car-3-ene,Canadian J of Chemical Engineering. 65(5) (1987) 818

75. D.Mukesh,C.S.Narasimhan,V.M.Deshpande,K.Ramnaryanan,Kinetics and mathematical modelling of methyl linoleate isomerization on supported Ru-Ni catalyst, Recent Trends in Chem. React. Engng. , Ed. Kulkarni, Mashelkar, Sharma, Wiley Eastern Edn. (1987) 116

76. D.Mukesh,A.R.Cooper,On-line non-interacting control and partial simulation of a continuous stirred tank reactor, Indian Chemical Engr.,29(4),(1987) 11

77. D.Mukesh,A.R.Cooper,Effect of reaction order & operating point on limit-cycle behaviour of a C.S.T.R., 38th I.I.Ch.E. congress (17/20 Dec 1985) Calcutta, India ,Indian Chem.Engr.,29(3),1987,32-36

78. D.Mukesh,C.S.Narasimhan,V.M.Deshpande,Temperature oscillations during ethanol oxidation over vanadium pentoxide catalyst, 2nd Indo-Soviet seminar on recent advances in catalysis & catalytic react. engng., Hyderabad (Nov 25/28, 1986)

79. D.Mukesh,A.R.Cooper,Effect of sampling on limit-cycle behaviour of a C.S.T.R., Chem. Engng.Sci., 41(3) (1986) 597

80. D.Mukesh, C.S.Narasimhan, R.Gadkari, V.M.Deshpande,Kinetics & mathematical modelling of isomerisation of methyl linoleate, Pt I : Isomerisation & hydrogenation, I & E.C. (Product R & D) 24 (2) (1985) 318

81. Ibid, pt II : Isomerisation & polymerisation, I & E.C. (Product R & D), 24 (2) (1985) 324

82. V.M.Deshpande,R.G.Gadkari,D.Mukesh,C.S.Narasimhan,Studies on kinetics of catalytic isomerisation of methyl linoleate, J.A.O.C.S., 62(4) (1985) 734

83. V.Kenkre,D.Mukesh,C.S.Narasimhan,Oxidation of ethanol on V2O5 based catalyst,Advances in Catalysis Science & Technology,Wiley Eastern Ltd.,New Delhi,p455

84. D.Mukesh,W.Morton,C.N.Kenney,M.B.Cutlip,Island models & the catalytic oxidation of CO & CO olefin mixtures, Surface Sci., 138 (1984) 237

85. D.Mukesh,A.R.Cooper,Operating a C.S.T.R. at open loop unstable point; effect of the controlled variable on dynamics, Indian Chem. engr, 26(4) (1984)

86. D.Mukesh,A.R.Cooper,Partial simulation and control of a C.S.T.R. using a digital computer, I & E.C. (fund), 22(1) (1983) 145.

87. M.B.Cutlip,C.J.Hawkins,D.Mukesh,W.Morton,C.N.Kenney,Modelling of forced periodic oscillations of CO oxidation over platinum catalyst, Chem.Engng.Commn,22(5/6) (1983) 329

88. D.Mukesh,M.Goodman,C.N.Kenney,W.Morton,Oscillatory phenomena in heterogeneous catalysed oxidation reactions, Specialist periodical reports, Royal Chemical Society, Vol 36, Catalysis 6 (1983)

89. D.Mukesh,C.N.Kenney,W.Morton,Concentration oscillations of CO,O2 and 1-butene over Pt supported catalyst, Chem.Engng.Sci., 38(1) (1983) 69

90. M.G.Goodman,M.B.Cutlip,C.N.Kenney,W.Morton,D.Mukesh,Transient studies of CO oxidation over Pt supported catalyst,Surface Sci.,120(2), (1982) L4536.

91. D.Mukesh, M.B.Cutlip, M.Goodman, C.N.Kenney, W.Morton,The stability and oscillations of CO oxidation over Pt supported catalyst : Effect of 1-butene, Chem.Engng.Sci., 37(2),(1982) 1807

92. P.S.Neelakantan,D.Mukesh,Computer modelling of continuous evaporative crystalliser, I & E.C. (process des & dev) 18(1), (1979)56

93. M.A.Parameswaran,D.Mukesh,Computer aided design of pneumatic conveyor, Chemical Engineering World, 13 (10), (Oct 1978) 41.

94. D.Mukesh,Ch.Durgaprasada rao,Stability & Dynamics of Cascade Reactors with Control only on the first reactor, I & E.C.(process des & dev) 16(2),(1977)166.

95. D.Mukesh,C.S.Sivaprasada rao,Adsorption & Desorption Studies on Silica Gel, Indian Chem. engg. 17(4),(Oct-Dec 1975)29

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Books Authored

*     Mukesh D and Anil Kumar (Feb, 2005) Biotreatment of industrial effluents, Elsevier, New york.

*     Mukesh D, Gaikar V and Anil Kumar (Feb 2004) Biotransformations & Bioprocesses, Marcell Dekker, New york.

*     Bhaduri S and Mukesh D (2000) Homogeneous catalysis : Mechnanisms & industrial applications., John Wiley & sons inc., New york.

Current Projects

Biodegradation of Polymers
QSAR and QSPR studies on anti-inflammatory and anti cancer molecules

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PRESENTATIONS AT CONFERENCES

*     International Conference on Intelligent Sensing, Madras (2004)

*     Indian Institute of Chemical Engineers Annual Meeting (Pune-1994,Mumbai- 1997)
*     National Catalysis Symposium (Bhuvaneswar, 1992)
*     ICI Technology conference (1991, UK)
*     American Chemical Society Annual Conference (Chicago, USA, Sept, 1985)
*     International Chemical Reaction Engineering Conf, (Pune, 1985)

AWARDS AND OTHERS

*     Editorial Board of Chemical Engineering, McGraw Hill Publ, USA (2003-)
*     Indian Institute of Chemical engineers 'Herdilla award' for Excellence in Basic research in Chemical engineering (1995).
*     Prof Kane visiting fellowship, UICT, Bombay (2003-2004)
*     Lupin India visiting fellowship, UICT, Bombay (2002)
*     Dai Ichi Karkaria Fellowship, UICT, Bombay (2000)
*     Chinnamaul prize for best technical paper presented, IIChE Annual conf (1994).
*     Commonwealth scholarship for doing PhD at UK

INVITED LECTURES

*     Royal Chemical Society of England, Bombay Chapter (2004)
*     Barathidasan University, Trichy (2004)
*     Sashun Chemicals and Drugs ltd, Chennai (2004)
*     Mechanical Engineering Soc. IIT, Madras (2003)
*     Modelling and simulation of Industrial Problems, IC&SR, IIT Madras (2003)
*     Association of food technologists, University Institute of Chemical Technology, Bombay (1998)
*     Proctor and Gamble ltd, Bombay (1998)
*     BARC, Bombay (1997)
*     Regional Research Lab, Bhopal (1995)