The DS-11 Series of Spectrophotometer/Fluorometers from DeNovix and the NanoDrop™ One Spectrophotometer are both used to perform fast quantification of nucleic acids and proteins. The spectrophotometer/fluorometer range from DeNovix provides superior limits of detection, the widest dynamic range, an easy-to-use interface and powerful networking features, which surpass the capabilities of the NanoDrop™ Spectrophotometer. Here we will outline the difference between the DeNovix DS-11 FX Spectrophotometer/Fluorometers and the NanoDrop™ One Spectrophotometer.