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Faculty

Nitish R Mahapatra

Ph.D., Indian Institute of Chemical Biology

M.Sc., University of Calcutta

Professor

nmahapatra@iitm·ac·in

Office : BT 504

+91-44-2257-4128

Research Interests

  • Molecular genetics of cardiovascular and metabolic diseases

  • Discovery and functional analysis of human genetic variations

  • Mechanisms of cholesterol homeostasis

  • Catecholamine-regulatory pathways

  • Discovery of novel biomarkers for cardiometabolic disorders

  • Interactions of bioactive peptides with their receptors

  • Protein structure-function studies

Publications

Complete list of publications can be found on Scopus

I. Representative Original Research Articles.

1. Iyer DR, Arige V, Ananthamohan K, Sundaramurthy V, Tokinoya K, Aoki K, Kurtz CL, Sethupathy P, Takekoshi K, Mahapatra NR. 2023. Cyclic-AMP response element binding protein (CREB) and microRNA miR-29b regulate renalase gene expression under catecholamine excess conditions. Life Sci. 328:121859.

2. Allu PK, Kiranmayi M, Mukherjee SD, Chirasani VR, Garg R, Vishnuprabu D, Ravi S, Subramanian L, Sahu BS, Iyer DR, Maghajothi S, Sharma S, Ravi MS, Khullar M, Munirajan AK, Gayen JR, Senapati S, Mullasari AS, Mohan V, Radha V, Naga Prasad SV, Mahapatra NR. 2022. Functional Gly297Ser variant of the physiological dysglycemic peptide pancreastatin Is a novel risk factor for cardiometabolic disorders. Diabetes 71:538–553. (Cover page article)

3. Maghajothi S, Subramanian L, Mani P, Singh M, Iyer DR, Sharma S, Khullar M, Victor SM, Asthana S, Mullasari AS, Mahapatra NR. 2022. A common Matrix metalloproteinase 8 promoter haplotype enhances the risk for hypertension via diminished interactions with nuclear factor kappa B. J Hypertens 40:2147-2160

4. Khan AA, Sundar P, Natarajan B, Gupta V, Arige V, Reddy SS, Barthwal MK, Mahapatra NR. 2021. An evolutionarily-conserved promoter allele governs HMG-CoA reductase expression in spontaneously hypertensive rat. J Mol Cell Cardiol 158:140-152 (Cover page article).

5. Khan AA, Agarwal H, Reddy SS, Arige V, Natarajan B, Gupta V, Kalyani A, Barthwal MK, Mahapatra NR. 2020. MicroRNA-27a is a key modulator of cholesterol biosynthesis. Mol Cell Biol 40: e00470-19.

6. Subramanian L, Maghajothi S, Singh M, Kesh K, Kalyani A, Sharma S, Khullar M, Victor SM, Swarnakar S, Asthana S, Mullasari AS, Mahapatra NR. 2019. A common tag nucleotide variant in MMP7 promoter increases risk for hypertension via enhanced interactions with CREB (cyclic AMP response element-binding protein) transcription factor. Hypertension 74:1448-1459.

7. Arige V, Agarwal A, Khan AA, Kalyani A, Natarajan B, Gupta V, Reddy SS, Barthwal MK, Mahapatra NR. 2019. Regulation of Monoamine Oxidase B Gene Expression: Key Roles for Transcription Factors Sp1, Egr1 and CREB, and microRNAs miR-300 and miR-1224. J Mol Biol 431:1127-1147.

8. Subramanian L, Khan AA, Allu PKR, Kiranmayi M, Sahu BS, Sharma S, Khullar M, Mullasari AS, Mahapatra NR. 2017. A haplotype variant of the human chromogranin A gene (CHGA) promoter increases CHGA expression and the risk for cardiometabolic disorders. J Biol Chem 292:13970-13985.

9. Gupta V, Kapopara PR, Khan AA, Arige V, Subramanian L, Sonawane PJ, Sasi BK, Mahapatra NR. 2017. Functional promoter polymorphisms direct the expression of cystathionine gamma-lyase gene in mouse models of essential hypertension. J Mol Cell Cardiol 102: 61-73 (Cover page article).

10. Kiranmayi M, Chirasani VR, Allu PK, Subramanian L, Martelli EE, Sahu BS, Vishnuprabu D, Kumaragurubaran R, Sharma S, Bodhini D, Dixit M, Munirajan AK, Khullar M, Radha V, Mohan V, Mullasari AS, Naga Prasad SV, Senapati S, Mahapatra NR. 2016. Catestatin Gly364Ser variant alters systemic blood pressure and the risk for hypertension in human populations via endothelial nitric oxide pathway. Hypertension 68:334-347.

11. Kalyani A, Sonawane PJ, Khan AA, Subramanian L, Ehret GB, Mullasari AS, Mahapatra NR. 2015. Post-transcriptional Regulation of Renalase Gene by miR-29 and miR-146 MicroRNAs: Implications for Cardio-metabolic Disorders. J Mol Biol 427: 2629-2646.

12. Gupta V, Khan AA, Sasi BK, Mahapatra NR. 2015. Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia-like conditions: key roles for the transcription factors GATA2, Sp1 and TBP. J Neurochem 134:21-38.

13. Allu PK, Chirasani VR, Ghosh D, Mani A, Bera AK, Maji SK, Senapati S, Mullasari AS, Mahapatra NR. 2014. Naturally occurring variants of the dysglycemic peptide pancreastatin: differential potencies for multiple cellular functions and structure-function correlation. J Biol Chem 289: 4455–4469.

14. Sasi BK, Sonawane PJ, Gupta V, Sahu BS, Mahapatra NR. 2014. Coordinated transcriptional regulation of Hspa1a gene by multiple transcription factors: crucial roles for HSF-1, NF-Y, NF-κB and CREB. J Mol Biol 426:116-35.

15. Sahu BS, Mohan J, Sahu G, Allu PKR, Subramanian L, Sonawane PJ, Singh PK, Sasi BK, Senapati S, Maji SK, Bera AK, Gomathi BS, Mullasari AS, Mahapatra NR. 2012. Functional genetic variants of the catecholamine-release-inhibitory peptide catestatin in an Indian population: allele-specific effects on metabolic traits. J Biol Chem 287: 43840-43852.

16. Sahu BS, Mohan J, Sahu G, Singh PK, Sonawane PJ, Sasi BK, Allu PKR, Maji SK, Bera AK, Senapati S, Mahapatra NR. 2012. Molecular interactions of the physiological anti-hypertensive peptide catestatin with the neuronal nicotinic acetylcholine receptor. J Cell Sci 125: 2323–2337.

II. Representative Book Chapters/ Review Articles.

1. Iyer DR, Venkatraman J, Tanguy E, Vitale N, Mahapatra NR. 2023. Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis. Cell Mol Life Sci. 80:271.

2. Hazra J, Vijayakumar A, Mahapatra NR. 2023. Emerging Role of Heat Shock Proteins in Cardiovascular Diseases. In: Advances of Protein Chemistry and Structural Biology, 134, pp. 271-306. Academic Press Inc., United States.

3. Khan AA, Gupta V, Mahapatra NR. 2022. Key regulatory miRNAs in lipid homeostasis: Implications for cardiometabolic diseases and development of novel therapeutics. Drug Discov Today 27:2170-2180.

4. Vijayakumar A and Mahapatra NR. 2022. Renalase: a novel regulator of cardiometabolic and renal diseases. Hypertens Res 45:1582-1598.

5. Gupta V, Arige V, Mahapatra NR. 2019. Role of monoamine oxidases in heart diseases. In: Modulation of Oxidative Stress in Heart Disease (S. Chakraborti et al.; Eds). pp. 129-150. Springer Nature Singapore Private Limited, Singapore.

6. Mahata SK, Kiranmayi M, Mahapatra NR. 2018. Catestatin: A master regulator of cardiovascular functions. Curr Med Chem 25:1352-1374.

7. Mahapatra NR, Ghosh S, Mahata M, Bandyopadhyay GK, Mahata SK. 2017. Naturally Occurring Single Nucleotide Polymorphisms in Human Chromogranin A (CHGA) Gene: Association with Hypertension and Associated Diseases. In Chromogranins: from Cell Biology to Physiology and Biomedicine (Angelone T, Cerra M & Tota B; Eds), pp. 195-211. Springer International Publishing AG, Cham, Switzerland.

8. Sonawane PJ, Sahu BS, Mahapatra NR. 2011. Pharmacogenomics of cardiovascular drugs. In Drug Design-Basics and Applications (Doble M; Ed.), pp. 280-310. Tata-McGraw-Hill Publishers, New Delhi, India.

9. Sahu BS, Sonawane PJ, Mahapatra NR. 2010. Chromogranin A: a novel susceptibility gene for essential hypertension. Cell Mol Life Sci 67:861-874.

10. Mahapatra NR. 2008. Catestatin is a novel endogenous peptide that regulates cardiac function and blood pressure. Cardiovasc Res 80:330-338