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Faculty

Smita Srivastava

Smita Srivastava

Ph.D, Indian Institute of Technology Delhi,

M.S., Indian Institute of Technology Delhi

Associate Professor

smita@iitm.ac.in

Office : Block:2 BT 206

+91-44-2257-5144

Lab : Block:2 BT 211 Lab website ➔

Research Interests

  • Specialization: Biochemical Engineering.

  • Research expertise: Plant cell and microbial technology

  • Research Interest: Bioprocess development and optimization for large scale in vitro production of high-value phytochemicals and phytoremediation.

List of Publications

Book Chapters:
  1. Srivastava and A.K Srivastava (2008) Recent Advances of in vitro azadirachtin production. In: K. G. Ramawat, J.M. Merillon (Eds.) Biotechnology: Bioactive Molecules and Medicinal Plants. Springer, Germany. pp 234-250.

  2. Srikantan.C and Srivastava. S (2018) Bioreactor Design and Analysis for Large-Scale Plant Cell and Hairy Root Cultivation, in: Srivastava, V., Mehrotra, S., Mishra, S. (Eds.), Hairy Roots. Springer Singapore, Singapore, pp. 147-182. doi:10.1007/978-981-13-2562-5_7

  3. Srivastava S., Srivastava A.K. (2013) Biotechnology and Genetic Engineering for Alkaloid Production. In: Ramawat K., M-rillon JM. (eds) Natural Products. Springer, Berlin, Heidelberg

  4. Mohinudeen K., Devan K., Srivastava S. (2019) Bioprocessing of Endophytes for Production of High-Value Biochemicals. In: Singh H., Keswani C., Reddy M., Sansinenea E., Garc-a-Estrada C. (eds) Secondary Metabolites of Plant Growth Promoting Rhizomicroorganisms. Springer, Singapore

Research papers in International Journals
  1. Narayani M, Babu R, Chadha A, Srivastava S. Production of bioactive cyclotides: a comprehensive overview. Phytochemistry Reviews 19: 787-825 (2020). DOI

2.Narayani, M.K.N. Sai Varsha, Uma Rani Potunuru, W. Sofi Beaula, Suresh Kumar Rayala, Madhulika Dixit, Anju Chadha, Smita Srivastava,Production of bioactive cyclotides in somatic embryos of Viola odorata, Phytochemistry, Volume 156, Pages 135-141. DOI 2018.

  1. Chitra Srikantan, Suraishkumar G.K., Smita Srivastava. Effect of light on the kinetics and equilibrium of the textile dye (Reactive Red 120) adsorption by Helianthus annuus hairy roots. Bioresource Technology. DOI 2018.

  2. Narayani M., Anju Chadha, Smita Srivastava. Cyclotides from the Indian Medicinal Plant Viola odorata (Banafsha) Identifiation and Characterization. Journal of Natural Products. DOI 2017.

5 Narayani M., Anju Chadha, Smita Srivastava. Callus and cell suspension culture of Viola odorata as in vitro production platforms of known and novel cyclotides. Plant Cell Organ and Tissue Culture. DOI 2017.

  1. Aarthi V., Uma R. Potunuru, Madhulika Dixit and Smita Srivastava. Effect of fermentation parameters, elicitors and precursors on camptothecin production from the endophyte Fusarium solani. Bioresource Technology, 206, 104-111, 2016. DOI

  2. Aarthi V. and Smita Srivastava. Enhanced camptothecin production by ethanol addition in the suspension culture of the endophyte, Fusarium solani. Bioresource Technology, 188, 251-257, 2015. DOI

  3. Smita Srivastava and A. K. Srivastava. Effect of Elicitors and Precursors on Azadirachtin Production in Hairy Root Culture of Azadirachtaindica. Applied Biochemistry and Biotechnology, 172, 2286-2297, 2014. DOI

  4. Smita Srivastava and A. K. Srivastava. Production of the BiopesticideAzadirachtin by Hairy Root Cultivation of Azadirachta indicain Liquid-Phase Bioreactors. Applied Biochemistry and Biotechnology, 171, 1351-1361, 2013. DOI

  5. Smita Srivastava and A. K. Srivastava. Azadirachtin production by hairy root cultivation of Azadirachtaindicain a modified stirred tank reactor. Bioprocess and Biosystems Engineering, 35, 1549-1553, 2012. DOI

  6. Rajashekar Reddy, A. K. Srivastava and Smita Srivastava. Development of a mathematical model for growth and oxygen transfer in in vitro plant hairy root cultivations. Applied Biochemistry and Biotechnology, 167, 1831-1844, 2012. DOI

  7. Smita Srivastava and A. K. Srivastava. Strategies to overcome oxygen transfer limitations during hairy root cultivation of Azadiracta indica for enhanced azadirachtin production. Applied Biochemistry and Biotechnology, 167, 1818-1830, 2012. DOI

  8. Smita Srivastava and A. K. Srivastava. Statistical medium optimization for enhanced azadirachtin production in hairy root culture of Azadirachtaindica. In vitro Cellular and Developmental Biology-Plant, 48, 73-84, 2012. DOI

  9. Smita Srivastava and A. K. Srivastava. In vitro cultivation of azadirachtin production by hairy root cultivation of Azadirachta indica in nutrient mist bioreactor. Applied Biochemistry and Biotechnology, 166, 365-378, 2012. DOI

  10. Smita Srivastava and A. K. Srivastava. Biological phosphate removal by model based fed-batch cultivation of Acinetobacter calcoaceticus. Biochemical Engineering Journal, 40, 227-232, 2008. DOI

  11. Smita Srivastava, S. Harsh and A. K. Srivastava. Use of NADH fluorescence measurement for on-line biomass estimation and characterization of metabolic status in bioreactor cultivation of plant cells for azadirachtin (a biopesticide) production. Process Biochemistry, 43, 1121-1123, 2008. DOI

  12. Smita Srivastava and A. K. Srivastava. Biological phosphate removal by model based continuous cultivation of Acinetobacter calcoaceticus. Process Biochemistry, 41, 624-630, 2006. DOI

  13. Smita Srivastava and A. K. Srivastava. Studies on phosphate uptake by Acinetobacter calcoaceticusunder aerobic conditions. Enzyme and Microbial Technology, 36, 362-368, 2005. DOI

Indian/International Patents (applied for)

  1. Aparajitha Srinivasan, Chitra Srikantan, G.K. Suraishkumar and S. Srivastava. Indian patent application titled -Bioprocess Technique for production of secondary metabolites from plant cells using textile dye effluents- (Application no. TEMP/E-1/1694/2018-CHE).

  2. Narayani M., Anju Chadha and S. Srivastava. Indian Patent Application titled -An improved process of producing high yields of natural cyclotides from plant tissues- (Application no. 7030/CHE/2015; PCT/IN2016/000298; WO2017115383 A1).

  3. Aarthi V. and S. Srivastava. Indian Patent application titled -An optimized bioprocess for enhancing camptothecin yield from endophytes- (Application no. 3638/CHE/2013).

  4. A.K. Srivastava, V.S. Bisaria and S. Srivastava. Indian Patent application titled -Bioreactor and uses thereof- (Application no. 148/DEL/2010).

Research Guidance (Ongoing/Completed) at IIT Madras

Ph. D Projects:
  1. Narayani M. Thesis title: Studies on the production of therapeutic cyclotides in in vitro cultures of Viola odorata. (Thesis defended: January, 2018) (Co-guide: Dr. Anju Chadha)

  2. Aparajitha S. Thesis topic: Strategies for enhanced production of alpha-tocopherol in cell culture of Helianthus annuus(Sunflower). (ongoing since: December, 2011) (Co-guide: Dr. Karthik Raman)

  3. Chitra Srikantan. Thesis topic: Studies on phytoremediation of textile dyes by hairy root culture of Helianthus annuus. (ongoing since: December, 2012) (Co-guide: Dr. G.K. Suraishkumar)

  4. Khwajah Mohinudeen I.A.H. Thesis topic: Studies on production of camptothecin from the endophytes of Nothapodytes nimmoniana(ongoing since: July, 2015)

  5. Sarayu M. Thesis topic: Strategies to enhance camptothecin production in cell/tissue cultures of Nothapodytes nimmoniana(ongoing since: July, 2016)

  6. Hemalatha R. Thesis topic: Studies on production of camptothecin by cell suspension culture of Nothapodytes nimmoniana(ongoing since: Jan, 2017)

  7. Babu R. Thesis topic: Strategies to enhance the production of cyclotides in in vitro cultures of Viola odorata (ongoing since: July, 2017)

M.S (Research) Project:
  1. Aarthi V. Thesis title: Bioprocess development for in vitro production of camptothecin from the endophyte, Fusarium solani. (Completed: May, 2015)
B.Tech/Dual Degree Projects:
  1. Karthik D; Thesis title: Strategies for sustainable and enhanced production of camptothecin from the endophyte Fusarium solani(ongoing: June 2017)

  2. Geddam Rini Vandana; Thesis title: Studies on in vitro production of camptothecin from cell/tissue cultures of Nothapodytes nimmoninana(completed: June, 2017)

  3. Ashok M., Production of camptothecin by the endophytic fungus Fusarium solani(completed: March, 2015)

  4. Uma Maheshwari Selvaraj; Thesis title: Studies on production of camptothecin and napthoquinones by submerged fermentation of Fusarium solani. Completed (June, 2012- May, 2013)

5 Rajashekar Reddy; Thesis title: Development of a mathematical model to describe growth and oxygen transfer in high density hairy root cultivations. Completed (June, 2011- May, 2012)

  1. Vigneswaran G., Thesis title: In vitro production of alpha-tocopherol (Vitamin E) by genetically transformed cell culture of Helianthus annus(Sunflower). Completed (June, 2011-May, 2012)

  2. Mandati Kumar, Thesis title: To study the role of n-hexadecane as a cell permeability enhancer and/or oxygen vector for enhanced production of alpha-tocopherol (Vitamin E) in cell suspension culture of Helianthus annuus(Sunflower). Completed (June 2011-May, 2012)

Post-doc Projects:
  1. Rashmi Sinha. Project title: Over-expression of the enzyme p-hydroxyphenylpyruvate dioxygenase (HPPD) for enhanced production of alpha-tocopherol in cell culture of Helianthus annuus(Sunflower). IIT-Madras Short term women-PDF Project. (Completed: February, 2012-2013)

  2. Rashmi Sinha. Project title: siRNA silencing of homogentisate geranylgeranyl transferase (HGGT) enzyme for enhancement of alpha-tocopherol in Helianthus annuus (Co-mentor: Dr. Baskar R.). UGC women-PDF Project (ongoing since: May, 2014)

Research supervision as Co-guide:
  1. Aarthi R. PhD Thesis topic: Rational development of microbial consortia for metabolic engineering. Guide: Dr.Karthik Raman (ongoing since: July, 2013)
Awards & Honors
  1. 5th National Award for Technology Innovation in various Field of Petrochemicals and Downstream Plastic Processing Industry, Minsitry of Chemicals and Fertilisers, GoI-Research in the Field of Polymer Science & Technology for the Innovation in -Antimicrobial Food Wrap- has been selected as Runner up for 5th National Award for Technology Innovation. -2015

  2. Indian Institute of Chemical engineering CHEMCON-2014: Sartorius India Chemcon Distinguished Speaker Award - 2014

  3. Fellow of Royal scoiety of chemistry, England (2010)

  4. Indian Institute of Chemical engineers -Herdilla award- for Excellence in Basic research in Chemical engineering (1995).

  5. The Dow Professor M.M. Sharma Distinguished Visiting Professorship in Chemical Engineering- for the year 2012-2013 at Institute of Chemical Technology, Mumbai

  6. Prof Kane visiting fellowship, Institute of Chemical Technology, Mumbai (2003-2004)

  7. Lupin India visiting fellowship, Institute of Chemical Technology, Mumba (2002)

  8. Dai Ichi Karkaria Fellowship, Institute of Chemical Technology, Mumbai (2000)

  9. Editorial Board of Chemical Engineering, McGraw Hill Publ, USA (2003-2017)

  10. Editorial Board of Indian Institute of Chemical Engineering, (2016-)

  11. Member of American Instititute and India Institute of Chemical Engineers

Professional affiliations

1.Founder membership- Biological Engineering Society (BESI)

2.Life time member of The Indian Science Congress Association (ISCA)

3.Life time associate member of India Institute of Chemical Engineers (IICHE)

4.Associate member of The Institution of Chemical Engineers (IChemE)

5.Life time member of Biotech Research Society of India (BRSI)

6.Fellow member of International society of Biotechnology (F.I.S.B.T)