Nathiya Muthalagu

Assistant Professor

PhD., University of Glasgow, Scotland, UK.

M.Sc., University of Madras, Chennai, TN, India.

Office: BT  Block 1- 301
Tel: +91-44-2257-4136
Email: nathiya@iitm.ac.in
Lab: BT – (Website)

Research Interests

Pancreatic cancer evolution, Cellular plasticity, Metastasis, chemoresistance, Mouse models

Molecular Oncology Lab

The overarching goal of our lab is to understand, at the molecular and cellular level how oncogenes control neuroendocrine plasticity, how this contributes to metastasis and how we can target this to improve the clinical outcome of patients.Using combined cellular and mouse models, coupled with analysis of human pancreatic and breast cancer samples, our lab will strive to identify new therapeutic targets for neuroendocrine tumours, with focus on metastasis and chemo resistance.

Publications :

  • Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu R, Whyte, D., Hedley, A., Laing, S., Upstill-Goddard, R., Shaw, R., Neidler, S., Gyuraszova, K., Nixon, C., Clark, W., Biankin, A., Carlin, L., Coffelt, S., Sansom, O. J., Morton, J. & Murphy, D. J. (2020) Repression of Type I Interferon pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B cells in Pancreatic Ductal Adenocarcinoma, Cancer Discov. 10 (6):872-87.
  • Bott, A. J., Shen, J., Tonelli, C., Zhan, L., Sivaram, N., Jiang, Y. P., Yu, X., Bhatt, V., Chiles, E., Zhong, H., Maimouni, S., Dai, W., Velasquez, S., Pan, J. A., Muthalagu, N., Morton, J., Anthony, T. G., Feng, H., Lamers, W. H., Murphy, D. J., Guo, J. Y., Jin, J., Crawford, H. C., Zhang, L., White, E., Lin, R. Z., Su, X., Tuveson, D. A. &Zong, W. X. (2019) Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism, Cell Rep. 29, 1287-1298 e6.
  • Muthalagu, N. & Murphy, D. J. (2018) Is oxidative stress MYC’s Achilles heel?,Cell Death Differ. 25, 1189-1190.
  • Port, J*., Muthalagu, N*., Raja, M., Ceteci, F., Monteverde, T., Kruspig, B., Hedley, A., Kalna, G., Lilla, S., Neilson, L., Brucoli, M., Gyuraszova, K., Tait-Mulder, J., Mezna, M., Svambaryte, S., Bryson, A., Sumpton, D., McVie, A., Nixon, C., Drysdale, M., Esumi, H., Murray, G. I., Sansom, O. J., Zanivan, S. R. & Murphy, D. J. (2018) Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress, Cancer Discov. 8, 632-647 (* Equal contributors).
  • Farrell, A. S., Joly, M. M., Allen-Petersen, B. L., Worth, P. J., Lanciault, C., Sauer, D., Link, J., Pelz, C., Heiser, L. M., Morton, J. P., Muthalagu, N., Hoffman, M. T., Manning, S. L., Pratt, E. D., Kendsersky, N. D., Egbukichi, N., Amery, T. S., Thoma, M. C., Jenny, Z. P., Rhim, A. D., Murphy, D. J., Sansom, O. J., Crawford, H. C., Sheppard, B. C. & Sears, R. C. (2017) MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance, Nat Commun. 8, 1728.
  • Sarosiek, K. A., Fraser, C., Muthalagu, N., Bhola, P. D., Chang, W., McBrayer, S. K., Cantlon, A., Fisch, S., Golomb-Mello, G., Ryan, J. A., Deng, J., Jian, B., Corbett, C., Goldenberg, M., Madsen, J. R., Liao, R., Walsh, D., Sedivy, J., Murphy, D. J., Carrasco, D. R., Robinson, S., Moslehi, J. &Letai, A. (2017) Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics, Cancer Cell. 31, 142-156.
  • Monteverde, T., Muthalagu, N., Port, J. & Murphy, D. J. (2015) Evidence of cancer-promoting roles for AMPK and related kinases, FEBS J. 282, 4658-71.
  • Murphy, D. J. &Muthalagu, N. (2015) BIM’s up first, Mol Cell Oncol. 2, e975083.
  • Ichim, G., Lopez, J., Ahmed, S. U., Muthalagu, N., Giampazolias, E., Delgado, M. E., Haller, M., Riley, J. S., Mason, S. M., Athineos, D., Parsons, M. J., van de Kooij, B., Bouchier-Hayes, L., Chalmers, A. J., Rooswinkel, R. W., Oberst, A., Blyth, K., Rehm, M., Murphy, D. J. & Tait, S. W. G. (2015) Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death, Mol Cel 57, 860-872.
  • Muthalagu, N., Junttila, M. R., Wiese, K. E., Wolf, E., Morton, J., Bauer, B., Evan, G. I., Eilers, M. & Murphy, D. J. (2014) BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues, Cell Rep. 8, 1347-53.
  • Liu, L., Ulbrich, J., Muller, J., Wustefeld, T., Aeberhard, L., Kress, T. R., Muthalagu, N., Rycak, L., Rudalska, R., Moll, R., Kempa, S., Zender, L., Eilers, M. & Murphy, D. J. (2012) Deregulated MYC expression induces dependence upon AMPK-related kinase 5, Nature. 483, 608-12.