General area: Better understanding and manipulation of biological systems.
Specific area: Reactive species (RS), the molecular mediators of cellular stress, based manipulations.
Current application: RS-based improvement in production of biologicals in space (under microgravity).
Archanaa Sundararaghavan, Amitava Mukherjee, Swagatika Sahoo and G. K. Suraishkumar (2020). "Mechanism of the oxidative stress-mediated increase in lipid accumulation by the bacterium, R. opacus PD630: Experimental analysis and genome-scale metabolic modeling. ", Biotechnology and Bioengineering, 117 , pp. 1779 - 1788, DOI: 10.1002/bit.27330 .
Bhalla, P., Rengaswamy, R., Karunagaran, D., Suraishkumar, G.K., Sahoo, S (2022). "Metabolic modeling of host–microbe interactions for therapeutics in colorectal cancer", npj Systems Biology and Applications, 8, pp. 1, DOI: 10.1038/s41540-021-00210-9.
Sridhar, S., Bhalla, P., Kullu, J., ... Bhatt, N., Suraishkumar, G.K. (2023). "A reactive species reactions module for integration into genome-scale metabolic models for improved insights: Application to cancer", Metabolic Engineering, 80, pp. 78–93, DOI: 10.1016/j.ymben.2023.08.006.
KrishnaPriya, S., Nair, P.S., Bhalla, P., Karunagaran, D., Suraishkumar, G.K. (2024). "Shear stress and microRNAs for better metastatic cancer management", Biotechnology Progress, 40, pp. e3396, DOI: 10.1002/btpr.3396.
Suraishkumar, G.K. (2024). "Reactive Species: Manipulations Toward Desired Outcomes in Biological Systems", Reactive Species: Manipulations Toward Desired Outcomes in Biological Systems, pp. 1–174, DOI: 10.1142/13774.