Department of Biotechnology | Indian Institute Of Technology Madras , Chennai
team

Nathiya Muthalagu

Assistant Professor

Ph.D., University of Glasgow, Scotland, UK.

M.Sc., University of Madras, Chennai, TN, India.

Block 2, BT 122

044 2257 4136

nathiya[at]iitm[.]ac[.]in

Lab: Block 2, BT 108

044 2257 8994

Lab Website
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  • To understand, at the molecular and cellular level how oncogenes control neuroendocrine plasticity, how this contributes to metastasis and chemoresistance.
  • To characterize the mechanism of pancreatic neuroendocrine tumour progression using mouse models of pancreatic cancer.

  1. Farrell, A. S., Joly, M. M., Allen-Petersen, B. L., Worth, P. J., Lanciault, C., Sauer, D., Link, J., Pelz, C., Heiser, L. M., Morton, J. P.,Muthalagu, N., Hoffman, M. T., Manning, S. L., Pratt, E. D., Kendsersky, N. D., Egbukichi, N., Amery, T. S., Thoma, M. C., Jenny, Z. P., Rhim, A. D., Murphy, D. J., Sansom, O. J., Crawford, H. C., Sheppard, B. C. & Sears, R. C. (2017). "MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance", Nat Commun, 8, pp. 1728.
  2. Port, J., Muthalagu, N., Raja, M., Ceteci, F., Monteverde, T., Kruspig, B., Hedley, A., Kalna, G., Lilla, S., Neilson, L., Brucoli, M., Gyuraszova, K., Tait-Mulder, J., Mezna, M., Svambaryte, S., Bryson, A., Sumpton, D., McVie, A., Nixon, C., Drysdale, M., Esumi, H., Murray, G. I., Sansom, O. J., Zanivan, S. R. & Murphy, D. J (2018). "Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress", Cancer Discov, 8, pp. 632-647.
  3. Bott, A. J., Shen, J., Tonelli, C., Zhan, L., Sivaram, N., Jiang, Y. P., Yu, X., Bhatt, V., Chiles, E., Zhong, H., Maimouni, S., Dai, W., Velasquez, S., Pan, J. A., Muthalagu, N., Morton, J., Anthony, T. G., Feng, H., Lamers, W. H., Murphy, D. J., Guo, J. Y., Jin, J., Crawford, H. C., Zhang, L., White, E., Lin, R. Z., Su, X., Tuveson, D. A. &Zong, W. X. (2019). "Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism", Cell Rep, 29, pp. 1287-1298.
  4. Repression of Type I Interferon pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B cells in Pancreatic Ductal Adenocarcinoma (2020). "Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu R, Whyte, D., Hedley, A., Laing, S., Upstill-Goddard, R., Shaw, R., Neidler, S., Gyuraszova, K., Nixon, C., Clark, W., Biankin, A., Carlin, L., Coffelt, S., Sansom, O. J., Morton, J. & Murphy, D. J.", Cancer Discov, 10, pp. 872-87.