Research Interests
1.Molecular pathogenesis of HIV
In a factory, someone has to stand on the loading dock, checking the goods going out. By recognizing labels like bar codes on each shipment, the loading dock supervisor makes sure that the products get where they are supposed to go. A cell is like a factory: one of its most important jobs is to produce proteins, like transcription factors and nuclear transport receptors. But in cellular factories, the sorting task is complicated by the fact that proteins are used by the cell itself as well as delivered to outside "customers". Scientists are succeeding at deciphering the cell's complex bar-coding system. But, surprisingly, they have never managed to get at the loading dock itself to see how HIV PICs are actually shipped to their destinations.
Regulation of HIV-1 infectivity and pathogenesis of AIDS remain
central interests of the laboratory. Unlike the typical animal-oncoretroviruses,
lentiviruses such as HIV have the ability to infect and replicate
within non-cycling cells. Nucleo-cytoplasmic transport of the
viral genome is vital for the replication and assembly of many
viruses. Nuclear transport of Human immunodeficiency viral (HIV)
genome, for instance, is critical for productive infection in
non-dividing cells such as human macrophages. Our understanding
on the nuclear import of HIV preintegration complexes into the
nucleus of non-dividing cells remains rudimentary, and identification
of cellular protein(s) which interact with viral PICs is eagerly
awaited and will reveal cellular system that are important to
diverse and basic cellular processes. Our laboratory will focus
on two issues: mechanism of HIV PICs nuclear import, and signals
in PICs that regulate its nuclear import. To achieve this goal
we will clone and characterize the host genes that are involved
in this process. We will also attempt to identify how the host
genes interact with viral proteins to bring about the events of
HIV pathogenesis. Furthermore, a better understanding of nuclear
transport during viral infection might prove useful for designing
antiviral therapies and for designing delivery vectors for gene
therapy, which is a rapidly developing and increasingly important
area of research in biomedical sciences.
2. Regulation of nucleo-cytoplasmic transport proteins
Identification and characterization of protein nuclear transport
pathways
3. Tumor biology
a. Understanding the cross talk between
tumor suppressors and activators of cell proliferation
b. Understanding the role nucleolar
proteins in cell proliferation and tumor development.
Educational Background
* PhD.:
Madurai Kamaraj University, Madurai. India
* M.Sc.:
Madurai Kamaraj
University, Madurai. India
* B.Sc.:
Madurai Kamaraj University, Madurai. India |