Dr. Sathyanarayana N. Gummadi

Department of Biotechnology
Indian Institute of Technology Madras

B.Tech - Regional Engineering College, Suratkal, Mangalore University, India
M.Tech - Anna University, Chennai, India
PhD - Indian Institure of Technology Madras, India
PDF - Korea Research Institute of Biosciences and Biotechnology, South Korea
RA - University of Wisconsin-Madison, USA
Email ID - gummadi@iitm.ac.in
Landline - 044-2257-4114


Sathyanarayana N. Gummadi completed B.E. Chemical Engineering in 1994 from KREC (currently NIT Surathkal). After completing, he joined M.Tech Chemical Engineering at A.C. College of Technology, Anna University.Later, he joined Indian Institute of Technology Madras for doctoral program in 1996. In 1999, he obtained his PhD in Biochemical Engineering and pursued Post doctoral training at Korea Research Institute of Bioscience and Biotechnology, Taejon, South Korea and in the Department of Biochemistry, University of Wisconsin, USA. In 2003, he joined as Assistant Professor at Department of Biotechnology, Indian Institute of Technology Madras and currently he is working as Professor and teaching courses in the area of chemical and bioprocess engineering. His research interest includes recombinant protein production and purification, enzyme engineering, biodegradation, conversion of hemicellulose to industrial metabolites, protein involved in membrane biogenesis and nanoparticles for industrial applications

To his credit, he guided 18 PhD and 4 MS scholars, published more than 140 peer reviewed international publications, 4 books and 6 edited chapters in book. He received several awards including NASI Scopus Young Scientist award, Distinguished Bioengineer award from Scociety of Applied Biotechnology (SAB), Young Scientist award from Association of Microbiologists of India (AMI), Biotechnology Research Scociety of India (BRSI). He is a recipient of FELLOW from Royal Society of Chemistry, Andhra Pradesh Akademi of Sciences, Institution of Engineers India, BRSI, Association for the advancement of Biodiversity Science and SAB. He successfully completed 19 projects form DST, DBT and other government funding agencies. Apart from teaching and research he also served in several academic boards in various institutes and Universities.

Research Scholars

Rekha Rajesh

Ph.D Scholar

email id: bt15d047@smail.iitm.ac.in

Project title: Screening, isolation and characterization of multiple enzymes producing novel Bacillus sp. PM06 from sugarcane residue pressmud.

Present study: Objective of our research work is to screen, isolate and characterize novel organism from sugarcane waste pressmud for the production of industrially important enzymes, and to study its application on different agricultural waste residues.

Manoj Kumar S

Ph.D Scholar

email id: bt16d011@smail.iitm.ac.in

Project Title:Evaluation of Pseudomonas sp. in coffee wastewater treatment and understanding the enzymology of caffeine degradation.

Summary:Pseudomonas sp. isolated from soil of the coffee plantation area showed excellent caffeine degradation capability. Genomic sequencing of Pseudomonas sp., revealed presence of 5 genes, ndmA, ndmB, ndmC, ndmD and ndmE, which are involved in caffeine degradation. Currently, we are evaluating its potential to devise a complete coffee wastewater treatment strategy. In addition, we are also characterizing the genes involved in caffeine degradation for its application in food industries.

Susmit Chakraborty

Ph.D Scholar

email id: bt16d301@smail.iitm.ac.in

Project Title: Numerical Investigations on Enhanced Crude Oil Recovery by Microbial Flooding Within a Sandstone Formation

Summary: Our research is focused on developing conceptual, mathematical and numerical models to comprehensively study the influences of crucial physical, chemical, biological, environmental and operational parameters on in-Situ Microbial Enhanced Oil Recovery (MEOR) within sandstone oil field, and to devise optimization strategies for improving accountability and efficiency of MEOR. The developed models with relatively lower computational cost and running time are expected to improve the predictive capability to pre-select potential field candidates for successful MEOR implementation.

Vijayalakshmi N

Ph.D Scholar

email id: bt16d024@smail.iitm.ac.in

Project Title: Biochemical characterization of an esterase from Clostridium acetobutylicum with novel GYSMG pentapeptide motif at the catalytic domain and significance of conserved motif

Summary:Clostridium acetobutylicum (ATCC 824) is an industrially important solventogenic microbe for the production of acetone, butanol and ethanol. Gene CA_0816 encodes esterases. This gene was overexpressed in E. coli strain BL21and purified using Ni 2+ -NTA affinity chromatography. Sequence analysis predicts that Ca-Est predicts the presence of catalytic amino acids Ser 89, His 224 and Glu 196. presence of novel GYSMG conserved sequence (instead of GDSAG and GTSAG motif) and undescribed variation of HGSG motif of microbial HSL. Significance of this variant conserved motif has to be studied experimentally.

Mukundamala Y

Ph.D Scholar

email id: bt18d023@smail.iitm.ac.in

Project Title: Cloning, Purification and Characterization of the Arabitol Dehydrogenase from Debaryomyces nepalensis.

Summary: Debaryomyces nepalensisNCYC 3413could able to catabolize pentose sugars of Lignocellulosic Biomaterials and produce Bioethanol. In this pathway, industrially important intermediate metabolites like Arabitol, Xylulose and Xylitol are produced. Our objective is Arabitol dehydrogenasegene identification, isolation, cloning, overexpression, purification and biochemical characterization. As it catalyzes arabitol to xylulose.

Vishnu Damodaran Nambissan

Ph.D Scholar

email id: bt19d017@smail.iitm.ac.in

Project Title:Enhancing Production of Xylitol from DebaryomycesnepalensisNCYC 3413and Biorefinery approach to Lignocellulosic Waste Valorisation.

Summary:The present study aims to enhance Xylitol production using different fermentation strategies and effectively degrade lignin using different pretreatment methods.

Pranjali Singh

Ph.D Scholar

email id: bt19d028@smail.iitm.ac.in

Project Title:Characterisation of NdmA component of methylxanthine oxygenase system in Pseudomonas sp. NCIM 5235 and whole cell applications for treatment of industrial coffee wastewater

Summary:The caffeine degrading bacteria Pseudomonas sp. NCIM 5235 utilizes caffeine as sole growth substrate by metabolizing caffeine via N-demethylation (Ndm). This process involves various components out of which we will carry out biochemical characterization of NdmA component (monooxygenase). We plan to optimize Pseudomonas sp. NCIM 5235 for pilot-scale coffee wastewater treatment by studying its interaction with other microbes in the wastewater. Also, we will analyse cells immobilized with compatible nanoparticles for its efficacy in treatment of industrial coffee wastewater.

Amit Kumar Behera

Ph.D Scholar

email id: bt20d023@smail.iitm.ac.in

Project Title: Analysis of caffeinedegradationand their resulting compoundsusing whole cell& non-cellular approaches for the industrial applications

Summary:This research work aims to study and compare thedegradationefficacyof caffeine with cellular & non-cellular approaches, and analyse the resulting products. Furthermore, optimization of process conditions for microbial production of industrially relevant molecules from the caffeine will be carried out.

Akilandaeswari J

Ph.D Scholar

email id: bt20d201@smail.iitm.ac.in

Project Title: Elucidation of enzyme mechanism and over production of xylose reductase in bacterial expression systems

Summary:Objective of the study is to elucidate the bi-substrate mechanism of converting xylose to xylitol by recombinant xylose reductase (XR) from Debaryomyces neplaensis NCYC 3413 which is cloned and expressed in E. coli Rosetta, optimization of cofactor regeneration system for economical production of xylitol and optimization of immobilized conditions for effective usage of XR for xylitol production. Futher optimization of media and fermentor operation conditions and scale up of process for enhanced production of recombinant XR is also planned.

Saivi Singh

Ph.D Scholar

email id: bt20d202@smail.iitm.ac.in

Project Title: Production of Xylitol from Halotolerant Yeast Debaryomyces nepalensis NCYC 3413 and its Purification

Summary:Batch and fed-batch fermentation of D. nepalensis in bioreactor and scale-up, followed by modelling of fed-batch operation, and purification of xylitol.

Sambita Das

Ph.D Scholar

email id: bt21d095@smail.iitm.ac.in

Project Title: Molecular Basis of Heavy Metal Apoptosis: Role of Human Scramblase

Summary:Objective of our research work is to focus on the biophysical and biochemical interactions happening between human scramblases with the metal ions and to study the expression and interactomes of human scramblases in heavy metal mediated apoptosis..