Dr. Sathyanarayana N. Gummadi

Department of Biotechnology
Indian Institute of Technology Madras

B.Tech - Regional Engineering College, Suratkal, Mangalore University, India
M.Tech - Anna University, Chennai, India
PhD - Indian Institure of Technology Madras, India
PDF - Korea Research Institute of Biosciences and Biotechnology, South Korea
RA - University of Wisconsin-Madison, USA
Email ID - gummadi@iitm.ac.in
Landline - 044-2257-4114


Sathyanarayana N. Gummadi completed B.E. Chemical Engineering in 1994 from KREC (currently NIT Surathkal). After completing, he joined M.Tech Chemical Engineering at A.C. College of Technology, Anna University.Later, he joined Indian Institute of Technology Madras for doctoral program in 1996. In 1999, he obtained his PhD in Biochemical Engineering and pursued Post doctoral training at Korea Research Institute of Bioscience and Biotechnology, Taejon, South Korea and in the Department of Biochemistry, University of Wisconsin, USA. In 2003, he joined as Assistant Professor at Department of Biotechnology, Indian Institute of Technology Madras and currently he is working as Professor and teaching courses in the area of chemical and bioprocess engineering. His research interest includes recombinant protein production and purification, enzyme engineering, biodegradation, conversion of hemicellulose to industrial metabolites, protein involved in membrane biogenesis and nanoparticles for industrial applications

To his credit, he guided 18 PhD and 4 MS scholars, published more than 140 peer reviewed international publications, 4 books and 6 edited chapters in book. He received several awards including NASI Scopus Young Scientist award, Distinguished Bioengineer award from Scociety of Applied Biotechnology (SAB), Young Scientist award from Association of Microbiologists of India (AMI), Biotechnology Research Scociety of India (BRSI). He is a recipient of FELLOW from Royal Society of Chemistry, Andhra Pradesh Akademi of Sciences, Institution of Engineers India, BRSI, Association for the advancement of Biodiversity Science and SAB. He successfully completed 19 projects form DST, DBT and other government funding agencies. Apart from teaching and research he also served in several academic boards in various institutes and Universities.

Research Scholars

Postdoctoral Fellow

Dr. Anjali Jaiwal

Women Scientist Scheme- A (Department of Science and Technology)

PROJECT TITLE- Regulation of expression of hPLSCR1, hPLSCR2 and hPLSCR4 human scramblase genes by Sox5 transcription factor

The human plasma membrane contains specific proteins called Human phospholipid scramblases (hPLSCRs). There are four homologes of scamblase, hPLSCR1-hPLSCR4. Except for Snail and c-Myc, no other transcription factor (TF) has been reported to regulate the expression of hPLSCRs. So, here, we are trying to study the transcriptional regulation of hPLSCRs by another TF, Sox5. Sox5 TF is a protein of the SOX (SRY- related HMG box) family involved in embryonic development and determines the fate of a cell.

Dr. HarshinyMuthukamar

The SERB-National Post Doctoral Fellowship (N-PDF)

PROJECT TITLE- Biocide photocatalytic Nanofibers– An Approach to enhance activity of fiber in Water treatment

Current research Currently we are working for • Development of novel natural polymeric nanocomposite nanofiber supported Ag-FeO nanoparticles • Characterization of the developed polymeric nanocomposite nanofiber to study the influence of Ag-FeO in surface and functional properties • Performance evaluation of the fabricated Ag-FeONanofiber for their biocide photocatalytic activity and water treatment robustness Forthcoming Research Plan The aims of our work is to develop superabsorbent nanofiber/ nanocomposite made of natural fibrils and evaluate the potentialities of use of them

Dr. B. Sirisha Boddapati

Women Scientist (WOS A)

PROJECT TITLE- “Production and Application of Microbial Mutanase for Prevention and Reduction of Dental Plaques

SUMMARY- Mutanases (1-3α-glucanases) has potential for inhibiting dental plaqueformation by suppressing the formation of mutanby promoting the degradation of mutan into low-molecular-weight glucans. In the present study mutan( mixed linkage of α-1-3 and α-1-6) was synthesized from Streptococcus mutans and characterization studies were conducted. The mutanwill be used as a substrate in the production of enzyme mutanase from microorganisms. Invitro studies will be conducted to study the rate of hydrolysis of mixed biofilms (carcinogenic streptococcus strains) by using mutanase enzyme.

Muhasin K

Ph.D Scholar

email id: bt15d038@smail.iitm.ac.in

Biochemical characterization of phospholipid scramblase 1 (SCRM-1) from Caenorhabditis elegans

PL scramblases are a family of protein present in eukaryotes which mediate bidirectional PL translocation. PL scramblases from several different organisms have been characterized so far. Genome of C elegans possess eight PL scramblases, scramblase 1 through 8. SCRM-1 of C. elegans shows 41% sequence identity with human PL scramblase 1 (hPLSCR1). Sequence alignment revealed that all the functional domains of hPLSCR1 are also present in SCRM-1. In the current study we are aiming to functionally characterize SCRM-1 through biophysical and biochemical approaches.
Rekha Rajesh

Ph.D Scholar

email id: bt15d047@smail.iitm.ac.in

Project title: Screening, isolation and characterization of multiple enzymes producing novel Bacillus sp. PM06 from sugarcane residue pressmud.

Present study: Objective of our research work is to screen, isolate and characterize novel organism from sugarcane waste pressmud for the production of industrially important enzymes, and to study its application on different agricultural waste residues.

Manoj Kumar S

Ph.D Scholar

email id: bt16d011@smail.iitm.ac.in

Project Title:Evaluation of Pseudomonas sp. in coffee wastewater treatment and understanding the enzymology of caffeine degradation.

Summary:Pseudomonas sp. isolated from soil of the coffee plantation area showed excellent caffeine degradation capability. Genomic sequencing of Pseudomonas sp., revealed presence of 5 genes, ndmA, ndmB, ndmC, ndmD and ndmE, which are involved in caffeine degradation. Currently, we are evaluating its potential to devise a complete coffee wastewater treatment strategy. In addition, we are also characterizing the genes involved in caffeine degradation for its application in food industries.

Susmit Chakraborty

Ph.D Scholar

email id: bt16d301@smail.iitm.ac.in

Project Title: Numerical Investigations on Enhanced Crude Oil Recovery by Microbial Flooding Within a Sandstone Formation

Summary: Our research is focused on developing conceptual, mathematical and numerical models to comprehensively study the influences of crucial physical, chemical, biological, environmental and operational parameters on in-Situ Microbial Enhanced Oil Recovery (MEOR) within sandstone oil field, and to devise optimization strategies for improving accountability and efficiency of MEOR. The developed models with relatively lower computational cost and running time are expected to improve the predictive capability to pre-select potential field candidates for successful MEOR implementation.

Vijayalakshmi N

Ph.D Scholar

email id: bt16d024@smail.iitm.ac.in

Project Title: Biochemical characterization of an esterase from Clostridium acetobutylicum with novel GYSMG pentapeptide motif at the catalytic domain and significance of conserved motif

Summary:Clostridium acetobutylicum (ATCC 824) is an industrially important solventogenic microbe for the production of acetone, butanol and ethanol. Gene CA_0816 encodes esterases. This gene was overexpressed in E. coli strain BL21and purified using Ni 2+ -NTA affinity chromatography. Sequence analysis predicts that Ca-Est predicts the presence of catalytic amino acids Ser 89, His 224 and Glu 196. presence of novel GYSMG conserved sequence (instead of GDSAG and GTSAG motif) and undescribed variation of HGSG motif of microbial HSL. Significance of this variant conserved motif has to be studied experimentally.

Mukundamala Y

Ph.D Scholar

email id: bt18d023@smail.iitm.ac.in

Project Title: Cloning, Purification and Characterization of the Arabitol Dehydrogenase from Debaryomyces nepalensis.

Summary: Debaryomyces nepalensisNCYC 3413could able to catabolize pentose sugars of Lignocellulosic Biomaterials and produce Bioethanol. In this pathway, industrially important intermediate metabolites like Arabitol, Xylulose and Xylitol are produced. Our objective is Arabitol dehydrogenasegene identification, isolation, cloning, overexpression, purification and biochemical characterization. As it catalyzes arabitol to xylulose.

Vishnu Damodaran Nambissan

Ph.D Scholar

email id: bt19d017@smail.iitm.ac.in

Project Title:Enhancing Production of Xylitol from DebaryomycesnepalensisNCYC 3413and Biorefinery approach to Lignocellulosic Waste Valorisation.

Summary:The present study aims to enhance Xylitol production using different fermentation strategies and effectively degrade lignin using different pretreatment methods.

Pranjali Singh

Ph.D Scholar

email id: bt19d028@smail.iitm.ac.in

Project Title:Characterisation of NdmA component of methylxanthine oxygenase system in Pseudomonas sp. NCIM 5235 and whole cell applications for treatment of industrial coffee wastewater

Summary:The caffeine degrading bacteria Pseudomonas sp. NCIM 5235 utilizes caffeine as sole growth substrate by metabolizing caffeine via N-demethylation (Ndm). This process involves various components out of which we will carry out biochemical characterization of NdmA component (monooxygenase). We plan to optimize Pseudomonas sp. NCIM 5235 for pilot-scale coffee wastewater treatment by studying its interaction with other microbes in the wastewater. Also, we will analyse cells immobilized with compatible nanoparticles for its efficacy in treatment of industrial coffee wastewater.

Amit Kumar Behera

Ph.D Scholar

email id: bt20d023@smail.iitm.ac.in

Project Title: