People

Prof. S.Mahalingam

Senior Scientists

Ph.D Students

Masters Students

Project Staffs

Alumni

Next

Prof. S. Mahalingam

Professional Experience

  • May 2010 to Present : Professor, Dept. of Biotechnology, Indian Institute of Technology Madras, Chennai.

  • May 2007 - May 2010 : Associate Professor, Dept. of Biotechnology, Indian Institute of Technology Madras, Chennai.

  • May 2005 - May 2007 : Staff Scientist-V, Centre DNA Fingerprinting and Diagnostics, Hyderabad.

  • Aug - Dec. 2003 : Visiting Scientist, Institute of Molecular and Cellular Biology, Singapore.

  • Mar - May 2002 : Visiting Scientist, University of Pittsburgh, Pittsburgh, USA.

  • Oct 2000 - Apr 2005 : Staff Scientist-IV, Centre DNA Fingerprinting and Diagnostics, Hyderabad.

  • 1997 - 2000 : Research Associate, University of Alabama, Birmingham, USA.

  • 1996 - 1997 : Research Associate, University of Pennsylvania, Philadelphia, USA.

  • 1993 - 1995 : Postdoctoral Fellow, Thomas Jefferson Univ, Philadelphia, USA.

  • 1988 - 1992 : Graduate student, Madurai Kamaraj Univ. India.
Research Interests 
    1. Molecular pathogenesis of HIV/AIDS
  1.  Virus-host interaction, mechanism of HIV mediated cell cycle arrest, and role of integrase during very early steps in viral infection.
  2. 2. Regulation of nucleo-cytoplasmic transport proteins
  3.  Identification and characterization of protein nuclear and nucleolar transport using both cellular and viral proteins.
  4. 3. Cancer biology
  5. a. Understanding the cross talk between tumor suppressors and activators of cell proliferation, mechanism of Ras associated tumor suppressor mediated cell growth control.
  6. b. Nucleolus on cell proliferation and cancer: Nucleolus play a very important role in rRNA production, processing, and ribosome biogenesis. Understanding the role nucleolar proteins in cell proliferation and tumor development is critical.
  7. c. Cancer Genomics: Cancer specific biomarkers for early detection and drug target identification, Development of cancer Genome database specific to Indian population.
  8. d. Genomics of pancreatic cancer and childhood leukemia.

Honors/Awards

  • Outstanding Research Investigator award (2009), Department of Atomic Energy, Government of India.
  • Member, National advisory committee, DST, Government of India (2010 - 2013).
  • Export member, Medical Biotechnology task force, DBT, Government of India (2009 - 2012).
  • Chairman, Board of Studies in Biotechnology, University of Madras, Chennai (2009 - 2012).
  • Elected member, Guha research Conference, India (2007 - 2010).
  • Elected member, Immunology forum of India (2007 - 2010).

Patents

  • Cellular Receptor for HIV-1 Vpr essential for G2/M phase transition of the cell cycle. (# 08/949,202) (D.B. Weiner, S. Mahalingam, V. Ayyavoo and M. Patel)US patent.
  • Functional fragments of HIV-1 Vpr protein and the method of using the same. (S. Mahalingam, V. Ayyavoo, M. Patel, T. Kieber-Emmons and D.B.Weiner) US Patent.
  • Novel nucleolar GTPase and methods for controlling proliferation of cells. Balasundaram. D. Du.X., and Mahalingam. S. US patent filed.

Other scientific activities

  • Editorial member, Nature Scientific Reports, Nature Publications, London (2019).
  • Editorial member, International Journal of Virology- Academic Journals, New York (2005-2009).
  • Ad-hoc reviewer for (a) for Virology, Academic Press (b) Journal of Virology, American Society for Microbiology.
  • Organized the 5th Transcriptional Assembly meeting, August 2002, CDFD, Hyderabad (as an organizer).
  • Organized the “International conference on HIV pathogenesis” December 2006, Hyderabad (as an organizer).
  • Organized the 77th Society of Biological Chemists of India meeting at IIT-Madras Chennai, Dec 2008 (as an co-organizer).
  • Organized the International conference on cancer Biology: Molecular mechanism and Novel Therapeutics at IIT-Madras, Chennai (as an organizer).
  • Organized the “International conference on Cancer Biology: Molecular Mechanisms and Novel Therapeutics” February 2010 at IIT-Madras, Chennai (as an organizer).
  • Organized the “International conference on Cancer Biology: Molecular Mechanisms and Novel Therapeutics” February 2014 at IIT-Madras, Chennai (as an organizer).
Next

Senior Scientists

Dr.S.Ananthi

She is working as Senior Scientist from July 2013 to till date. She finished her bachelor’s, master’s and master of philosophy degrees in Microbiology. She obtained her doctorate degree for Bio Medical Sciences from Madurai Kamaraj University. Her major research involves in identification & validation of prognostic biomarkers using proteomic approaches in oral cancer. In addition, she is been involved in understanding the role of RASSF proteins in regulating miRNA 1 & 133A2 and comparative analysis of RASSF [1,7,10] through proteome wide approach.

Dr.Lakshmi Revathi Perumalsamy, Ph.D

Senior Scientist ( October 2013- present)

She is working on the role of RASSFs particularly RASSF7 in regulation of tumor metastasis. Her current primary focus is to understand RASSF7 regulation of metastasis and inflammation. She obtained her integrated Master's (Hons) in Biological sciences and Bachelor's (Hons.) degree in Computer Science from Birla Institute of Technology and Science, Pilani (BITS-Pilani). Her doctoral thesis at National Centre for Biological Science (NCBS), Bangalore under the guidance of Dr. Apurva Sarin described a novel spatial regulation of Notch activity in mediating cell survival.

Next

Ph.D Students

Debduti Datta

She is a CSIR Senior Research Fellow (SRF) and she is working on signaling pathways associated with tumor biology. A major part of the work involves molecular characterization of novel nucleolar GTPases in breast cancer. She obtained her bachelor’s degree (B.Sc.) in Zoology and master’s degree (M.Sc.) in Zoology from University of Pune.

Satya Prakash Singh

Satya Prakash Singh is a Ph.D student and he is working on HIV/SIV accessory proteins such as Vpr and Vpx. Major part of his work involves understanding the mechanism by which these accessory proteins help in early stage of virus life cycle. He obtained his bachelor’s degree in Biology and master’s degree in Biotechnology.

Indu Jose

Indu Jose T. (CSIR-SRF) is a graduate student who joined the lab, her work focuses on the functional characterization of a putative nucleolar GTPase, namely GNL3L. She obtained her bachelor's degree (B.Sc) in Biotechnology (Kasturba Medical College, Manipal Academy of Higher Education) and post graduation degree (M.Sc) in Molecular Biology (Institute of Basic Medical Sciences, University of Madras).

Sneha Priya

R.Sneha Priya, is a GATE fellowship student, who joined as M.S student in Laboratory of Molecular Virology and later upgraded to direct Ph.D. She has completed her Bachelor of Technology (B.Tech) degree in Biotechnology. Her research objective primarily is to study the Indian subtype C HIV-1 envelope protein(Env). As part of the study, she is characterizing unique functional domains in the cytoplasmic tail of a chronic Indian HIV-1 isolate. Secondly, based on characterization, She is designed a new Env based immunogen as a candidate AIDS vaccine, whose efficacy will be tested in rabbits and in process of testing in macaques.

Anbarasu K

K. Anbarasu is a PhD student, he is working on functional characterization of RAS Association domain containing family member which is a RAS effector and a potential tumor suppressor. He obtained his bachelor's degree (B.Sc.) and master's degree (M.Sc.) in Biotechnology from Bharathiar University.

Isai Pratha

Isai pratha is a Senior Research Fellow (SRF) and joined as a PhD student. She is working on functional characterisation of RASSF8 and a major part of her work involves in understanding the transcriptional regulation of RASSF8. She obtained her bachelor’s degree (B.Sc) and master’s degree (M.Sc) in Biochemistry.

Rajasekhar Reddy

He is a CSIR-UGC Senior Research Fellow (SRF) and has joined as a PhD student. He is working on functional characterization of RAS association domain family1, comparing the effects of RASSF1A and RASSF1C and studying the transcriptional regulation of RASSF1C. He obtained his bachelor’s in Microbiology and master’s degree in Biotechnology.

Rehna Krishnan

Rehna Krishnan is a CSIR Junior Research Fellow (JRF) and she is working on the functional characterization of Guanine nucleotide binding protein like 1 and a major part of her work involves role of this protein family in ribosome biogenesis and nucleolar stress pathway. She obtained her bachelor’s degree (B. Sc.) in Microbiology and master’s degree (MSc) in Microbiology.

Raghul Kumar

Raghul Kumar is a HTRA Research Scholar who joined as a MS student and upgraded to Ph.D. He is working on functional characterization of Protein-Protein Interactions involving RASSFs 1,7,10 and the signalling pathways modulated by them. He obtained his Bachelor's degree (B.Tech) in Biotechnology.

Next

Master Students

TBD

Next

Project Staff

Indu . P

Indu .P is working as a Project Assistant since May 2009. She manages all project accounts and lab requirements.

Pavitra

Pavitra is working as a project associate since November 2013. She is Involved in characterising the functional role of RASSF7- a tumor suppressor protein on cellular metabolism. She obtained her bachelor’s degree (B.Tech) in Biotechnology and her master’s degree (MS) in Biological sciences.

Durairaj

Durairaj is working as a Project Associate since March 2014. He takes care of DNA sequencing and maintaining the Cancer Tissues Repository. He obtained both his BSc and MSc in Biochemistry.

Vinoth

Vinoth Kumar is working as a Project Assistant since July 2013. He is Involved in collecting Cancer Tissue samples from various Hospitals in Chennai.

Christopher

Christopher is working as a Project Assistant since Oct. 2013. He is Involved in collecting Cancer Tissue samples from various Hospitals in Chennai.

Surya

Surya R is working as a Project Assistant since January 2014. He is Involved in collecting Cancer Tissue samples from various Hospitals in Chennai.

Next

Alumni

Post-Doctorates

Dr. M. Yamuna

Dr. Yogendra S. Padwad

Ph.D Students

Rajendra Kumar

Prabhat K. Singhal

MRK Subba rao

Gita Kumari

Neelima Boddapati

Pankaj Gupta

MS Students

Prushotham

Santosh Pathak

Subir Biswas

Narayanan S

Ravishankar A

Sujitha

Pandey R C

Reshma V

Dual degree students

Srivats

Sri Teja Mullapudi

Harsh Nagpal

B.Tech students

Prathik

Chaitra

Project Staffs

Vijaya Kumar C

Mahesh K

Suryaraja R

Sunny BSR

Junetha Syed

Anitha Mamidi

Selvasankar

Prabu Pandi

Velmurugan

Next