Endothelial Cells

The primary objective of this project is to understand molecular pathways initiating endothelial dysfunction in diabetic settings. We isolate and culture endothelial cells derived from umbilical cords in presence of diabetic conditions such as hyperglycemia and lipotoxicity prior to determining signalling changes via molecular and cellular biology approaches. At present the major focus is to understand the involvement of protein tyrosine phosphatases and associated adapter molecules in regulation of eNOS and other signalling intermediates.
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Endothelial Progenitor Cells

It is not clear as to how diabetic pathology causes dysfunction of circulating EPCs to compromise neo-vascularization. Additionally, the status of EPCs in Asian Indians is presently unknown. Hence, the objective of this project is to determine circulating levels of EPCs in healthy versus diabetic Asian Indian subjects. The other objective of the project is to determine molecular and cellular differences in cultured EPCs obtained from these study subjects.
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Smooth Muscle Cells

The objectives of this project is to determine how pre-diabetes and diabetes alters the phenotype and molecular composition of smooth muscle cells. For this we use appropriate rodent models and excised atheroma samples from patients for performing gene expression studies.
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