D Karunagaran

D Karunagaran

Professor and Head of the Department

Institute Chair Professor
Bhupat and Jyoti Mehta School of Biosciences
Department of Biotechnlogy
IIT Madras

Ph.D, Sri Krishnadevaraya University
M.Phil, University of Madras

Office: BT 401
Tel: +91-44-2257-4126
Email: karuna@iitm·ac·in
Lab: BT 414 (Website)

Research Interests

Cancer Biology:

  • Mechanisms of Apoptosis activated by anticancer agents
  • Signaling by growth factors
  • NF-kappa B signaling

Publications

2018

  1. Patent on “A SYNERGISTIC ANTI-TUMOR COMPOSITION” Patent Number 1202/CHE/2006

Weblink: http://ipindiaservices.gov.in/PatentSearch/PatentSearch//ViewApplicationStatus?AppNumber=SeLDqLs3QJYO2rfsBEAaHg==

2017

  1. Chandrasekaran KS, Sathyanarayanan A, Karunagaran D. (2017). miR-214 activates TP53but suppresses the expression of RELA, CTNNB1, and STAT3 in human cervical andcolorectal cancer cells. Cell BiochemFunct.35, 464-471.(IF- 2.186, Citation-)
  2. Sathyanarayanan A, Chandrasekaran KS, Karunagaran D. microRNA-145 downregulates SIP1-expression but differentially regulates proliferation,migration, invasion and Wntsignaling in SW480 and SW620 cells. (2017). J Cell Biochem.doi: 10.1002/jcb.26365.(IF-3.446, Citation-)
  3. Sathyanarayanan A, Chandrasekaran KS, Karunagaran D. microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells. (2017). Cell Oncol.40, 119-131. (IF-3.786, Citation-8)

 

 

2016

 

  1. Sathyanarayanan A, Chandrasekaran KS, Karunagaran D. microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells. (2016). BiochemBiophys Res Commun.480, 528-533. (IF-2.466, Citation-10)

 

  1. Chandrasekaran KS, Sathyanarayanan A, Karunagaran D. MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells. (2016). J. Cancer115, 741-751. (IF-6.176, Citation-8)

 

  1. Chandrasekaran KS, Sathyanarayanan A, Karunagaran D. Downregulation of HMGB1 by miR-34a is sufficient to suppress proliferation, migration and invasion of human cervical and colorectal cancer cells. (2016). Tumour Biol.37, 13155-13166.(IF-2.926, Citation-8)

 

2015

  1. Thacker PC, Karunagaran D. (2015). Curcumin and Emodin Down-Regulate TGF-β Signaling Pathway in Human Cervical Cancer Cells. PLoS One.10 (3):(IF- ‎2.806, Citation-25)

 

  1. Anoosha P, Huang LT, Sakthivel R, Karunagaran D, Gromiha MM. (2015). Discrimination of driver and passenger mutations in epidermal growth factor receptor in cancer. Mutat Res.780, 24-34.(IF-2.133, Citation-7)

 

  1. Prabhavathy D, Subramanian CK, Karunagaran D. (2015). Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-κB activation induced by TNF-α concurrently increasing senescence and survival. Biosci Rep.25: 35(1)e00175. (IF-2.906, Citation-10)

 

  1. Karthikeyan C, Moorthy NS, Ramasamy S, Vanam U, Manivannan E, Karunagaran D, Trivedi P. (2015). Advances in chalcones with anticancer activities. Recent Pat Anticancer Drug Discov.10, 97-115.(IF-, Citation-)

 

2014

  1. Prabhavathy D, Vijayalakshmi R, Kanchana MP, Karunagaran D. (2014). HPV16 E2 enhances the expression of NF-κB and STAT3 target genes and potentiates NF-κB activation by inflammatory mediators. Cell Immunol.292, 70-77.(IF-2.956, Citation-38)

 

  1. Nair, C. K. K., Sandeep, D., Ramasamy, S., Krishnan, R., Karunagaran, D., & Al Suhaibani, E. (2014). Evaluation of Cytotoxic and Anti-Tumor Activities of Cosciniumfenestratum Extract. American Journal of Phytomedicine and Clinical Therapeutics, 2, 1346-1360.(IF-15, Citation-1)

 

  1. Pooja T, Karunagaran D. (2014) Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620. Eur J Pharmacol.742, 55-64.(IF-2.896, Citation-32)

 

  1. Subramanian M, Rao SR, Thacker P, Chatterjee S, Karunagaran D. (2014). MiR-29b Downregulates Canonical Wnt Signaling by Suppressing Coactivators of β -Catenin in Human Colorectal Cancer Cells. J Cell Biochem. 115, 1974-1984.(IF-3.446, Citation-23)

 

  1. Sreelatha T, Kandhasamy S, Dinesh R, Shruthy S, Shweta S, Mukesh D, Karunagaran D, Balaji R,Mathivanan N, Perumal PT. (2014) Synthesis and SAR study of novel anticancer and antimicrobialnaphthoquinone amide derivatives. Bioorg Med ChemLett. 24, 3647-3651.(IF-2.454, Citation-26)

 

  1. Prabhavathy D, Prabhakar BN, Karunagaran D. (2014) HPV16 E2-mediated potentiation of NF-κ Bactivation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-inducedapoptosis. Mol Cell Biochem. 394, 77-90.(IF-2.669, Citation-8)

 

  1. Raghu D, Karunagaran D. (2014) PlumbaginDownregulatesWnt Signaling Independent of p53 in Human Colorectal Cancer Cells. J Nat Prod. 77, 1130-1134(IF-3.281, Citation-10)

 

2013

  1. SavitaUdainiya and DevarajanKarunagaran (2013) MicroRNA-106b-25 cluster targets β-TRCP2, increases the expression of Snail and enhances cell migration and invasion in H1299 (Non-Small Cell Lung Cancer) cells. Biophys. Res. Commun.,434, 841-847(IF-2.354, Citation-43)

 

  1. John Victor, N., Sakthivel, R., Muraleedharan, K. M., and Karunagaran, D. (2013). N‐Substituted 1, 2‐Dihydroquinolines as Anticancer Agents: Electronic Control of Redox Stability, Assessment of Antiproliferative Effects, and Mechanistic Insights. ChemMedChem, 8, 1623-1628(IF-3.225, Citation-3)

 

  1. PushparathinamGopinath, Krishnan Ramalingam, KannothManheriMuraleedharan and DevarajanKarunagaran (2013) Benzisothiazolones arrest the cell cycle at the G2/M phase and induce apoptosis in HeLa cells. Chem. Commun., 4, 749-752(IF-2.608, Citation-4)

 

  1. Kumar, N., Dhurandhar, M., Aggarwal, B., Anant, S., Daniel, K., Deng, G., Djeu, J., Dou, J., Hawk, E., Jayaram, B., Jia, L., Joshi, R., Kararala, M., Karunagaran, D.,Kucuk, O., Kumar, L., Malafa, M., Samathanam, G. J., Sarkar, F., Siddiqi, M., Singh, R. P., Srivastava, A. and White, J. D. (2013). Proceedings of the Indo-U.S. bilateral workshop on accelerating botanicals/biologics agent development research for cancer chemoprevention, treatment, and survival. Cancer Medicine, 2,108–115.(IF-3.362, Citation-1)

 

  1. Juneja, Manisha, Uma Vanam, SripriyaParanthaman, Asha Bharathan, Venugopal S. Keerthi, Justus K. Reena, Rama Rajaram, Kallikat N. Rajasekharan, and DevarajanKarunagaran. (2013). 4-Amino-2-arylamino-5-indoloyl/cinnamoylthiazoles, analogs of topsentin-class of marine alkaloids, induce apoptosis in HeLa cells. European Journal of Medicinal Chemistry, 63, 474-483(IF-4.519, Citation-10)

 

  1. Suresh, S., D. Raghu, and Karunagaran. (2013). “Menadione (Vitamin K3) Induces Apoptosis of Human Oral Cancer Cells and Reduces their Metastatic Potential by Modulating the Expression of Epithelial to Mesenchymal Transition Markers and Inhibiting Migration.” Asian Pacific journal of cancer prevention: APJCP14, 5461-5465(IF-, Citation-14)

 

 

2012

 

  1. Kavitha K, VidyaPriyadarsini R, Anitha P, Ramalingam K, Sakthivel R, Purushothaman G, Singh AK, Karunagaran D, Nagini S. (2012). Nimbolide, a neemlimonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells. Eur J Pharmacol.681, 6-14.(IF-2.896, Citation-55)

 

  1. KarunagaranDevarajan, Maitreyi Subramanian, and Rao Srinivasa Rao. “Regulation of MicroRNAs by Natural Compounds: Implications for Cancer Therapy.” In Natural compounds as inducers of cell death, pp. 401-428. Springer Netherlands, 2012.(IF-, Citation-)

 

  1. Subramoniam A, Asha VV, Nair SA, Sasidharan SP, Sureshkumar PK, Rajendran KN, Karunagaran D, Ramalingam K. (2012) Chlorophyll Revisited: Anti-inflammatory Activities of Chlorophyll a and Inhibition of Expression of TNF-α Gene by the Same. Inflammation 35,959-966(IF-2.955, Citation-35)

 

 

2011

 

  1. SavitaUdainiya, Suhail Ahmed KabeerRasheed, Christoph Meyer, JörgHendrickLeupold, Paolo Ceppi, Steven Dooley, DevarajanKarunagaran, Mauro Papotti, Heike Allgayer (2011) Smad 7 induces invasion, migration and in vivo metastasis in Non Small Cell Lung Cancer. Amer. Assoc. Can. Res.(IF-, Citation-)

 

2010

  1. SumithRetnammaPanicker, PrethishSreenivas, Mani SankarBabu, DevarajanKarunagaran and ChandrasekharanCheranelloreKartha(2010) Quercetin attenuates Monocyte Chemoattractant Protein-1 gene expression in glucose primed aortic endothelial cells through NF-kB and AP-1. Pharmacol Res62, 328-336.(IF-4.480, Citation-36)

 

  1. Murugan RS, Priyadarsini RV, Ramalingam K, Hara Y, Karunagaran D, Nagini S. (2010). Intrinsic apoptosis and NF-κB signaling are potential molecular targets forchemoprevention by black tea polyphenols in HepG2 cells in vitro and in a rathepatocarcinogenesis model in vivo. Food ChemToxicol.48, 3281-3287. (IF-3.778, Citation-38)

 

  1. VidyaPriyadarsini R, SenthilMurugan R, Maitreyi S, Ramalingam K, KarunagaranD, Nagini S. (2010). The flavonoid quercetin induces cell cycle arrest andmitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53induction and NF-κB inhibition. Eur J Pharmacol.649, 84-91(IF-2.896, Citation-232)

 

  1. VidyaPriyadarsini, R.,SenthilMurugan, R., Sripriya, P.,Karunagaran,D. and Nagini, S. (2010) The neemlimonoidsazadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells. Free Radic Res.44,624-634 (IF-3.188, Citation-79)

 

  1. Marie Lue Antony, RemaNair , Paul SebastianandDevarajanKarunagaran (2010) Changes in expression, and/or mutations in TGF-b receptors (TGF-b RI and TGF-b RII) and Smad 4 in human ovarian tumors J Cancer Res ClinOncol136, 351-361(IF- 3.503

, Citation-37)

 

2009

  1. Sivakumar, KC, Thomas B, and Karunagaran D (2009) Three dimensional structure of the closed conformation (active) of human merlin reveals masking of actin binding site in the FERM domain J. Bioinformatics Research and Applications5, 516-524(IF-, Citation-2)

 

  1. Paul BT, Babu MS, Santhoshkumar TR, Karunagaran D, Selvam GS, Brown K, Woo T, Sharma S, Naicker S, Murugesan R. (2009) Biophysical evaluation of two red-shifted hypocrellin B derivatives as novel PDT agentsJPhotochemPhotobiol B.94, 38-44(IF-2.673, Citation-18)

 

2008

  1. Karunagaran D,Sripriya P, and Prabhakar BN. (2008) MicroRNAs: Novel and potential candidates for cancer therapy, ICFAI Journal of Biotechnology 2, 38-51(IF-, Citation-)

 

 

2007

  1. Karunagaran D, Joseph J, Kumar TR. (2007) Cell growth regulation, Exp. Med. Biol.,595, 245-268(IF-, Citation-)

 

  1. Saja K, Babu MS, Karunagaran D, and Sudhakaran PR (2007) Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cells. Immunopharmacol.7, 1659-1667.(IF-2.956, Citation-48)

 

2006

  1. ShlomitErlich, Pazit Tal-Or, Roy Blum, YoelKloog,DevarajanKarunagaran and RonitPinkas-Kramarski (2006)Ras Inhibition Results in Growth Arrest and Death of Androgen-Dependent and Androgen-Independent Prostate Cancer Cells. ,72, 427-436(IF-, Citation-)

 

  1. John Mohan, Alankaram Arul Gandhi, BalanChandrikaBhavya, RamachandranRashmi, DevarajanKarunagaran, RamachandranIndu, and ThankayyanRetnabhaiSanthoshkumar (2006) Caspase-2 triggers Bax-Bak dependent and independent cell death in colon cancer cells treated with resveratrol. J. Biol. Chem., 281, 17599-17611(IF- 4.581, Citation-39)

 

  1. Kumaraguruparan R, Karunagaran D, Balachandran C, Manohar BM, Nagini S (2006). Of humans and canines: A comparative evaluation of heat shock and apoptosis-associated proteins in mammary tumors. ClinChimActa. 365, 168-176(IF- 2.873, Citation-57)

 

2005

  1. ManickamVenkatraman, Ruby John Anto, Asha Nair, Merina Varghese and DevarajanKarunagaran (2005) Biological and chemical inhibitors of NF-kB sensitize SiHa cells to cisplatin-induced apoptosis. Carcinogenesis44, 51-59(IF-4.185, Citation-85)

 

  1. Karunagaran, R. Rashmi and T. R. Santhosh Kumar (2005) Induction of Apoptosis by Curcumin and Its Implications for Cancer Therapy. Curr. Cancer Drug Targets5, 117-129(IF-, Citation-)

 

  1. RamachandranRashmi, Santhosh Kumar and DevarajanKarunagaran (2005) Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL Carcinogenesis26, 713-723(IF-5.105, Citation-109)

 

 

  1. Smitha, V. B., Vinesh Kumar, T. P., Deepti, A., Nair, A., Karunagaran, D., and Anto, R. J. (2005). Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappa B and the serine/threonine kinase Akt and is independent of tubulin polymerization. Biol. Chem.,280, 6301-6308(IF-4.125, Citation-26)

 

 

2004

  1. RamachandranRashmi, Santhosh Kumar and DevarajanKarunagaran (2004) Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their downregulation potentiates it. Carcinogenesis25:1867-1877(IF-5.105, Citation-61)

 

 

  1. Tessy T Maliekal, Ruby John Anto and DevarajanKarunagaran (2004) Differential Activation of Smads in HeLa and SiHa Cells that Differ in their Response to Transforming Growth Factor-b. Biol. Chem.,279: 36287-36292(IF-4.125, Citation-26)

 

  1. SubyOommen, Ruby John Anto, GopalSrinivas and DevarajanKarunagaran(2004) Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. European Journal of Pharmacology485, 97-103(IF-2.896, Citation-266)

 

  1. RamachandranRashmi, Santhosh Kumar and DevarajanKarunagaran (2004) Ectopic Expression of Hsp70 Confers Resistance, and Silencing Its Expression Sensitizes Human Colon Cancer Cells to Curcumin-induced Apoptosis. Carcinogenesis25: 179-187(IF-5.105, Citation-95)

 

2003

  1. Tessy T Maliekal, Marie-Lue Antony, Asha Nair, RamasamyPaulmurugan and DevarajanKarunagaran (2003) Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer. Oncogene22, 4889-4897(IF-7.519, Citation-73)

 

  1. GopalSrinivas, Ruby John Anto, PriyaSrinivas, Subramanian Vidhyalakshmi, VijayammaPriyaSenan and DevarajanKarunagaran (2003) Emodin induces apoptosis of human cervical cancer cells through poly (ADP-ribose) polymerase cleavage and activation of caspase 9. J. Pharmacol.473, 117-125(IF-2.896, Citation-199)

 

  1. Ruby John Anto, ManickamVenkatraman, and DevarajanKarunagaran (2003) Inhibition of NF-kB sensitizes A431 Cells to EGF-induced apoptosis whereas its activation by Ectopic expression of RelA confers resistance Biol. Chem. 278, 25490-25498(IF-4.125, Citation-66)

 

  1. Rashmi, T. R. Santhosh Kumar, D. Karunagaran (2003) Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspasesFEBS Letters538, 19-24.(IF-3.519, Citation-100)

 

  1. Asha Nair, ManickamVenkatraman, Tessy T. Maliekal, Balaraman Nair, and DevarajanKarunagaran (2003) Nuclear Factor-kB is Constitutively Activated in High Grade Squamous Intraepithelial Lesions and Squamous Cell Carcinomas of the Human Uterine Cervix. Oncogene 22, 50-58.(IF-7.519, Citation-201)

 

  1. Asha Nair, S., Karunagaran, D., and Sudhakaran,P. R. (2003) Changes in matrix metalloproteinases and their endogenous inhibitors during tumor progression in the uterine cervix. J Cancer Res ClinOncol129, 123-131(IF-3.503, Citation-55)

 

2002

  1. Rabi T, Karunagaran D,Krishnan Nair M, Bhattathiri VN. (2002) Cytotoxic activity of amooranin and its derivatives. Res. 1, S84-86 (IF-3.092, Citation-27)

 

 

2000

  1. Anto, R. J., Maliekal, T. T., and (2000) L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis J. Biol.Chem. 275, 15601-15604(IF-4.125, Citation-75)

 

1997

  1. Chen, H., Yu, D., Chinnadurai, G., Karunagaran, D. and Hung, M. C. (1997) Mapping of adenovirus 5 E1A domains responsible for suppression of neu-mediated transformation via transcriptional repression of Oncogene 14, 1965-1971.(IF-7.519, Citation-35)

 

  1. Kiyokawa, N., Karunagaran, D., Lee, E.K., Xie, Y., Yan, D-H., and Hung, M.C. (1997) Involvement of cdc2-mediated phosphorylation in the cell cycle-dependent regulation of p185 neu.  Oncogene15, 2633-2641.(IF-7.519, Citation-11)

 

  1. Kiyokawa, N., Lee, E. K., Karunagaran, D., Lin, S-Y., and Hung, M.C. (1997) Mitosis-specific negative regulation of epidermal growth factor receptor triggered by a decrease in ligand binding and dimerization can be overcome by overexpression of receptor. Biol. Chem., 272, 18656-18665.(IF-4.125, Citation-61)

 

  1. Shao,R., Karunagaran, D., Zhou, B. P., Li, K., Lo, S-S., Deng, J., Chiao, P., and Hung, M. C. (1997) Inhibition of nuclear factor – kB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis. Biol. Chem., 272, 32739-32742.(IF-4.125, Citation-146)

 

 

 

1996

  1. Karunagaran, D., Tzahar, E., Beerli, R. R., Chen, X., Graus-Porta, D., Ratzkin, B., Seger, R., Hynes, N.E. and Yarden, Y. (1996) ErbB-2 is a common auxiliary subunit of NDF- and EGF-receptors: implications for breast cancer. J. 15, 254-264.(IF-9.792, Citation-775)

 

  1. Chen, X., Levkowitz, G., Tzahar, E., Karunagaran, D., Lavi, S., Ben-Baruch, N., Leitner, O., Ratzkin, B. J., Bacus, S. S. and Yarden, Y. (1996) An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4. Biol. Chem. 271, 7620-7629.(IF-4.125, Citation-155)

 

  1. Tzahar, E., Waterman, H., Chen, X., Levkowitz, G., Karunagaran, D., Lavi, S., Ratzkin, B.J. and Yarden, Y. (1996) AHierarchial Network of Interreceptor Interactions Determines Signal Transduction by Neu Differentiation Factor/Neuregulin and Epidermal Growth Factor. Cell. Biol. 16, 5276-5287.(IF-4.398, Citation-1043)

 

1995

  1. Karunagaran, D., Tzahar, E., Liu, N., Wen, D. and Yarden, Y. (1995) Neu Differentiation Factor Inhibits EGF Binding: A Model for Trans-Regulation Within the ErbB Family of Receptor Tyrosine Kinases. Biol. Chem., 270, 9982-9990.(IF-4.125, Citation-70)

 

  1. Lu, H.S., Chang, D., Philo, J. S., Zhang, K., Linda, O. N., Liu, N., Zhang, M., Sun, J., Wen, J., Yanagihara, D., Karunagaran, D., Yarden, Y. and Ratzkin, B. (1995) Studies on the Structure and Function of Glycosylated and Nonglycosylatedneu Differentiation Factors: Similarities and differences of the a and b J. Biol. Chem.  270, 4784-4791.(IF-4.125, Citation-44)

 

  1. Marikovsky, M., Lavi, S., Pinkas-Kramarski, R., Karunagaran, D., Liu, N., Wen, D. and Yarden, Y. (1995) ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes.  Oncogene, 10, 1403-1411.(IF-7.519, Citation-83)

 

1994

  1. Wen, D., Suggs, S. V., Karunagaran, D., Liu, N., Cupples, R. L., Luo, Y., Janssen, A. M., Ben-Baruch, N., Trollinger, D. B., Jacobsen, V. L., Meng, S-Y., Lu, H.S., Hu, S., Chang, D., Yanigahara, D. Koski, R.A. and Yarden, Y. (1994). Structural and Functional Aspects of the Multiplicity of Neu Differentiation Factors. Cell. Biol. 14, 1909-1919.(IF-4.398, Citation-257)

 

  1. Tzahar, E., Levkowitz, G., Karunagaran, D., Yi, L., Peles, E., Lavi.S., Chang, D., Liu, N., Yayon, A., Wen. D. andYarden, Y (1994) ErbB-3 and ErbB-4 Function as the Respective Low and High Affinity Receptors of All Neu Differentiation Factor/Heregulin Isoforms. Biol. Chem. 269, 25226-25233.(IF-4.125, Citation-305)

 

 

1993

  1. Dhanunjayanath, V., Karunagaran, D and Ramakrishna Rao, P. (1993) Effect of fluoride on germination and starch mobilization of horse gram seeds. Indian J. Plant Physiol., 36, 131-133.(IF-, Citation-1)

 

1992

  1. Karunagaran, D., Mohana, M.N and Usha, V. (1992). Influence of axis on hydrolase development in cowpea (Vignaunguiculata L.) cotyledons during germination. Indian J. Plant Physiol., 35, 300-304.(IF-, Citation-3)

 

1991

  1. Karunagaran, D. and Ramakrishna Rao, P. (1991) Mode and control of starch mobilization during germination of seeds of horse gram. Plant Sci, 73, 155-159.(IF- 3.437, Citation-14)

 

1990

  1. Karunagaran, D. and Ramakrishna Rao, P. (1990) Development of mitochondria in horse gram cotyledons during germination. Indian J. Plant Physiol., 33, 219-225(IF-, Citation-)

 

  1. Karunagaran, D. and Ramakrishna Rao, P. (1990) Axial control of protease development in cotyledons of horse gram (Macrotyloma uniform Lam.) seeds during germination. Indian J. Plant Physiol., 33, 232-238.(IF-, Citation-12)

 

1981

  1. Herbert Manoharan, T., Jayachandran, N., Karunagaran, D and Natarajan, K. R. (1981) Influence of Fluchloralin on the growth and metabolism of maize seedlings. The Plant Biochem. J., (India), 8, 103-116.(IF-, Citation-1)

 

  1. Herbert Manoharan, T., Thirunavukkarasu, A., Karunagaran, D. and Natarajan, K. R. (1981) Effects of Fluchloralin on the metabolism of cowpea ( Vignaunguiculata L.) seedlings. Indian J. Exp. Biol., 19, 943-947(IF-, Citation-)

 

Non-Peer Reviewed:

  1. D. Karunagaran and S.Asha Nair(2001) Relevance of Rel signaling in cancer Amala Research Bulletin 21: 1-3
  2. D. Karunagaran (2003) Fight against cancer continues, armed with novel biotechnological tools pp 68-74 In “A Compendium on the Focal Theme of National Science Day” State Committee on Science, Technology and Environment, Government of Kerala
  3. Cancer treatment: Novel biotechnological approaches, Kerala Calling, December 2003 18-20.
  4. Transforming growth factor-b signaling in cancer (2004) Amala Research Bulletin 24: 12-17
  5. Coercing cancer cells to commit suicide through molecular targeting. Advanced Biotech, October 2004, 15-18.

Books Published:

  1. Karunagaran, D., and Bharat Aggarwal (2003) Transcription factors as targets for drug development “In Pathomechanisms- New trends in drug research: Molecular mechanisms and new trends in drug development” Ed. Gyorgy Keri and IstvanToth, Taylor and Francis, London and New York
  2. Karunagaran, D. (2003) Relevance of Apoptosis to Cancer. In: Biotechnology: Emerging Trends. Joseph Selvin et al. (eds). Biotech Publishers, New Delhi
  3. Karunagaran, D. and Goodwin Jinesh (2008). TGF-b, Smads and Cervical Cancer. In Transforming Growth Factor-Beta in Cancer Therapy Volume II Cancer Drug Discovery and Development Jakowlew, Sonia (Ed.) The Humana Press, Inc., NJ, USA.
  4. Karunagaran, D. and Goodwin Jinesh(2005) Biotechnological approaches in the detection and treatment of cancer. In “Advances in Biotechnology” Ed. P. C. Trivedi, Agrobios (India), Jodhpur
  5. Karunagaran, Jeena Joseph and T. R. Santhosh Kumar (2007) Cell Growth Regulation by Curcumin. In “The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease “ Advances in Experimental Medicine and Biology, Vol. 595 Aggarwal, Bharat B.; Surh, Young-Joon; Shishodia, Shishir (Eds.) ,Springer Publishers, New York.
  6. Karunagaran D, Subramanian M, Rao RS (2012). Regulation of MicroRNAs by Natural Compounds: Implications for Cancer Therapy. (Chapter 16).M. Diederich (ed.), Natural Compounds As Inducers of Cell Death: Volume 1,Springer Science+Business Media Dordrecht

 

GENBANK SUBMISSIONS

 

Jinesh, G. and Karunagaran, D. (2004) Identification of new transcription factors Homo sapiens zinc finger domain-related protein TSRM (TSRM) mRNA, partial cds. GenBank Accession No. AY742823

Jinesh, G. and Karunagaran, D. (2007) Homo sapiens mothers against decapentapelagic homolog 3 [Smad3] alternatively spliced and mutant mRNA at exon8, 9 in SiHa cell line.GenBank Accession No.EU016554

Jinesh, G. and Karunagaran, D. (2007) Homo sapiens mothers against decapentapelagic homolog 3 [Smad3] mRNA, splicing error mutant in SiHa cell line, exon 3 to 6. GenBank Accession No.EU016553

Jinesh, G. and Karunagaran, D. (2007) Homo sapiens mothers against decapentapelagic homolog 3 [Smad3]intron-8 to exon-9 splicing error mutant mRNA in HeLa cell line.GenBank Accession No.EU016552

Antony,M. and Karunagaran,D.(2007) Mutated TGF beta RI in ovarian cancer. GenBank Accession No.EF142854

Antony,M. and Karunagaran,D.(2007) Mutated TGF beta RI in ovarian cancer. GenBank Accession No.EF142853