N Manoj

Associate Professor
Ph.D, Indian Institute of Science
M.Sc, University of Mysore
Office: BT 304
Tel: +91-44-2257-4113
Email: nmanoj@iitm·ac·in
Lab: BT 309 (Website)

Research Interests

  •  Structural biochemistry of hydrolases
  •  Protein structure and function
  •  Computational molecular evolution
  •  Bioinformatics


  • Ravisankar V, Singh TP, Manoj N. Molecular evolution of the EGF-CFC protein family. Gene 2011 482(1-2):43-50.
  • Prasobh R, Manoj N. The Repertoire of Heterotrimeric G Proteins and RGS Proteins in Ciona intestinalis. PLoS ONE 2009 4(10): e7349.
  • Kiranmayee B, Gummadi SN, Manoj N. Biochemical characterization of Alr1529, a novel SGNH hydrolase variant from Anabaena sp. PCC 7120. Biophys Biochem Acta – Proteins & Proteomics 2009 Feb;1794(2):324-34.
  • Kamesh N, Aradhyam GK, Manoj N. The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis. BMC Evol Biol. 2008 May 1;8:129.
  • Sahu SK, Gummadi SN, Manoj N, Aradhyam GK. Phospholipid scramblases: an overview. Arch Biochem Biophys. 2007 Jun 1;462(1):103-14. Review.
  • Manoj N, Ealick SE. Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase. Acta Cryst D 2003 Oct;59:1762-6
  • Manoj N, Strauss E, Begley TP, Ealick SE. Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Structure. 2003 Aug;11(8):927-36.
  • Manoj N, Suguna K. Signature of quaternary structure in the sequences of legume lectins. Protein Eng. 2001 Oct;14(10):735-45.
  • Manoj N, Jeyaprakash AA, Pratap JV, Komath SS, Kenoth R, Swamy MJ, Vijayan M. Crystallization and preliminary X-ray studies of snake gourd lectin: homology with type II ribosome-inactivating proteins. Acta Cryst D 2001 Jun;57:912-4
  • Saraswathi NT, Manoj N, Vijayan M. X-ray studies on crystalline complexes involving amino acids and peptides. XXXVII. Novel aggregation patterns and effect of chirality in the complexes of DL- and L-lysine with glutaric acid. Acta Cryst B. 2001 Jun;57:366-71.
  • Manoj N, Srinivas VR, Surolia A, Vijayan M, Suguna K. Carbohydrate specificity and salt-bridge mediated conformational change in acidic winged bean agglutinin. J Mol Biol. 2000 Oct 6;302(5):1129-37.
  • Manoj N, Vijayan M. X-ray studies on crystalline complexes involving amino acids and peptides. XXXVI. Crystal structures of hydrated glycyl-L-histidine and L-histidyl-L-alanine complexes with oxalic acid. J Pept Res. 2000 Oct;56(4):210-7.
  • Manoj N, Srinivas VR, Satish B, Singha NC, Suguna K. Crystallization and preliminary crystallographic analysis of winged bean acidic lectin. Acta Cryst D 1999 Feb;55:564-5.
  • Manoj N, Srinivas VR, Suguna K. Structure of basic winged-bean lectin and a comparison with its saccharide-bound form. Acta Cryst D 1999 Apr;55:794-800.

Chapter in book

S.N. Gummadi, N. Manoj, D. Sunil kumar (2006) Structural and biochemical properties of pectinases. In: “Industrial Enzymes: Structure, Function and Applications (eds. J. Polaina and A.P. MacCabe, Springer, pp 99-115