Rama S Verma

Rama S Verma

Professor
Ph.D., Jawaharlal Nehru University
M.Phil, Jawaharlal Nehru University
Office: BT 201
Tel: +91-44-2257-4109
Email: vermars@iitm·ac·in
Lab: BT 213 (Website)

Awards/Honors

  1. Fellow to The Indian Academy of Science (FNASc) 2014
  2. Fellow, Association of Microbiologists of India (FAMI) 2010
  3. Fellow, The Bio-Tech Research Society (BRSI) 2015
  4. Member, Board of Governor National Institute of Pharmaceutical Education and Research Mohali (Chandigarh) 2016- 2019
  5. Life Time Achievement Award, Nature Science Foundation Tamil Nadu 2017
  6. ABAP Senior Scientist Award, Society for Applied Biotechnology and Applied Pharmacy India 2014
  7. Elected Fellow to Society for Applied biotechnology – 2011
  8. Excellence in Medical biotechnology award (Society for Applied Biotechnology, India)- 2011
  9. Genomic Pioneer recognition award 2008 held at the HUGO’s International Human Genome Meeting held at Hyderabad, India 2008
  10. Chairman, Institute Technical committee IITM and Member Institute Ethic committee 2015 till present

Research Interests

1- Stem cell proliferation related studies

  • A- Role of Osteoblasts in Stem Cell Proliferation
    Hematopoiesis is an exquisitely regulated physiological process, which results in the appropriate production of blood cells throughout life. Over the past four decades our understanding of the cellular and molecular basis of hematopoietic regulation has become quite sophisticated. Several hematopoietic growth factor polypeptide hormones have been identified through molecular cloning, which play a key role in this process. In many respect, our current dynamic model of hematopoietic is the leading paradigm in molecular histology. It has established a framework to apply to cell differentiation and renewal in diverse tissue, including liver, skin and intestinal epithelium. Despite these advances, the most important details of the cellular and molecular regulation of stem cell self- renewal and differentiation remain elusive. We are currently addressing these issues through the following:
  1. Role of permissive and inductive microenvironment in bone marrow in context to proliferation of stem cell
  2. Role of osteoblast in the proliferation of stem cell
  • B- Stem Cell and its Regenerative Potential

2- Construction of Novel & New fusion Toxin (Immunotoxins)

Recombinant immunotoxins are antibody-toxin chimeric molecules that kill cancer cells via binding to a surface antigen, internalization and delivery of the toxin moiety to the cell cytosol. In the cytosol, toxins catalytically inhibit a critical cell function and cause cell death. The antibody portion of the chimera targets antigens that are expressed preferentially on the surface of cancer cells. Truncated versions of either diphtheria toxin (DT) or Pseudomonas exotoxin (PE) can be used to construct fusions with cDNAs encoding antibody fragments or cell- binding ligands. Presently, in our lab we have designed several novel constrct which are truncated version of known immunotoxins and novel humanized toxin utilizing the pre-apoptoctic segment of human origin to combat the problems associates with the immnogenicity of the toxin fragment and the non-targeted toxicity noted while treating certain cancers.

3- Cloning & Expression of Therapeutic Protein that have Clinical Importance

4- Development of MAB against EpCAM for Targeting Retinoblastoma with Nanoparticle

5- Biochemical and Molecular Characterization of membrane Protein Receptor) Presently our interest is in “Identification and Purification of Methotrexate Binding protein from the T Lymphocytes

6- Nanotechnology Using synthetic biodegradable micro-molecules and biodegradable biopolymer as scaffold for stem cell differentiation into cardiac tissue for heart injury repair.

 

Publications

 (A) International refereed journals (starting from recent)

  1. Self-Assembled Dual-Drug Loaded Core-Shell Nanoparticles based on Metal-Free Fully Alternating Polyester for Cancer Theranostics (2019) Piyush kumar Gupta and Rama Verma Materials Science & Engineering doi.org/10.1016/j.msec.2019.03.041 IF 5.9
  2. Noninvasive Tracking and Regenerative Capabilities of Transplanted Human Umbilical Cord-Derived Mesenchymal Stem Cells Labeled with I-III-IV Semiconducting Nanocrystals in Liver-Injured Living Mice (2019)Shashank Shankar Chetty, Selvarasu Praneetha , Kavitha Govarthanan, Rama Shanker Verma, and Arumugam Vadivel Murugan ACS Appl. Mater. Interfaces, 11 (9), 8763–8778 DOI: 10.1021/acsami.8b19953 IF 8.9
  3. Piyush Kumar Gupta, Santosh Gupta, Sreenath Pappuru, Siva Chander Chabattula, Debashis Chakraborty, Rama Shanker Verma (2019) Enhancing the anti-cancer therapeutic efficacy by optimizing molecular weight of metal-free fully alternating semi-aromatic polyester as nano-drug carriers Journal of Drug Delivery Science and Technology, 51, 101114doi.org/10.1016/j.jddst.2019.02.022 IF 2.9
  4. Metal-free Lewis pair catalyst synergy for fully alternating copolymerization of norbornene anhydride and epoxides (2019) Biocompatible tests for derived polymers Debashis Chakraborty, Anjaneyulu, k Anji, Piyush Gupta, Rama Verma, Sreenath Pappuru Materials Today Communications19, 306-314 https://doi.org/10.1016/j.mtcomm.2019.02.00
  5. Pavithra P.S., Alka Mehta and Rama S. Verma (2018) Essential oils: from prevention to treatment of skin cancer Drug discovery Today doi.org/10.1016/j.drudis.2018.11.020
  6. Rama Shanker Verma, Piyush Kumar Gupta, Maria Frolova and Arkady Ayzeshtadt(2018) High-throughput sequencing analysis of Microbial population in arctic rock sample Micro and Nano Technologies doi.org/10.5593/sgem2018/6.4
  7. Shashank Chetty S., Praneetha S., Vadivel Murugan , Kavitha Govarthanan  Rama S. Verma (2018)MicrowaveAssisted Synthesis of Quasi Pyramidal CuInS2-ZnS Nanocrystals for Enhanced NearInfrared Targeted Fluorescent Imaging of Subcutaneous Melanoma Advance Bosystem DOI: 10.1002/adbi.201800127
  8. Sangeetha Kandoi, Praveen Kumar L, Bamadeb Patra, Prasanna Vidyasekar, Divya Sivanesan, Vijayalakshmi S, Rajagopal K, Rama Shanker Verma (2018) Evaluation of platelet lysate as a substitute for FBS in explant and enzymatic isolation methods of human umbilical cord MSCs Nature Scientific Report 8:12439 doi:1038/s41598-018-30772-4Impact factor 4.3
  9. Diptendu Chatterjee Piyush Kumar Gupta, Santosh Gupta, and Rama Shanker VermaFanconi (2018), Anemia: A Rare Genetic Disorder in ManJIAS (Journal of Indian Anthropological Society) volume 53(3)
  10. Surajit Pathak, Roberto Catanzaroc, Dharani Vasand, Francesco Marottae, Yashna Chabriaa, Ganesan Jothimania, Rama Shanker Verma, Ramachandran Murugesana, Anisur Rahman Khuda-Bukhsh and Antara Banerjee(2018) Benefits of aged garlic extract in modulating toxicity biomarkers against  p-dimethylaminoazobenzene and phenobarbital induced liver damage in Rattus norvegicus Drug and Chemical Toxicology 12:1-14doi.org/10.1080/01480545.2018.1499773
  11. Zipporah E B, Govarthanan K, Shyamsunder P, Verma RS(2018) Expression Profiling of Differentially Regulated Genes in Fanconi Anemia. Methods Mol Biol.; 1783:243-258. doi: 10.1007/978-1-4939-7834-2
  12. Mahadev Potharaju MD, Balamurugan Mangaleswaran M Ch, Anugraha Mathavan MS, ReginaldJohn MCh, VincentThamburaj MCh, Siddhartha Ghosh MCh, Shankar Ganesh MCh, K. Chandrasekhar MCh, L. Murugan MCh, Suresh Bapu Mch, Rathna Devi DMRT, Rama Shankar Verma PhD (2018)Body mass index as a prognostic marker in Glioblastoma multiforme – a clinical outcome International Journal of Radiation Oncology Biology and Physics 102 (1) 204-209 doi.org/10.1016/j.ijrobp.2018.05.024ImpactFactor: 5.13
  13. Pavithra PS, Alka Mehta and Rama S Verma(2018)Synergistic interaction of β-Caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells Phytomedicine47 (1), 121-134 https://doi.org/10.1016/j.phymed.2018.05.001ImpactFactor: 3.6
  14. Shiv Kumar Viswanathan PhD, Megan J. Puckelwartz PhD, Ashish Mehta PhD,Chrishan J.A. Ramachandra PhD, Aravindakshan Jagadeesan BS, Regina Fritsche-Danielson PhD, Ratan V. Bhat PhD, Philip Wong, MBBS, Sangeetha Kandoi, MSc, Jennifer A. Schwanekamp PhD, Gina Kuffe, Lorenzo L. Pesce, PhD, Michael J. Zilliox, PhD, Nalla B. Durai, MD, Rama Shanker Verma, PhD, Robert E. Molokie, MD, Domodhar P. Suresh, MD, Philip R. Khoury, PhD, Annie Thomas, PhD, Thriveni Sanagala, MD, Hak Chiaw Tang, MBBS, Richard C. Becker, MD, Ralph Knöll, MD, PhD,Winston Shim, PhD, Elizabeth M. McNally, MD, PhD and Sakthivel Sadayappan, PhD,( 2018)Cosegregation of MYBPC3Δ25bp with MYBPC3 D389V is associated with a cardiomyopathic substrateJournal of Association Medical Association Cardiology USA (JAMA Cardiology)Jun 1;3(6):481-488. doi:10.1001/jamacardio.2018.0618 ImpactFactor 10.33
  15. Prashanta Kumar Panda, Prajna Paramita Naik, Prakash P Praharaj, Piyush Kumar Gupta, Rama S Verma, Tapas K Maiti, Muthu K Shanmugam, Arunachalam Chinnathambi5, Sulaiman Ali Alharbi, Gautam Sethi, Rajesh Agarwal and Sujit K Bhutia (2018) Abrus agglutinin stimulates BMP2 dependent differentiation through autophagic degradation of β-catenin in colon cancer stem cells Molecular Carcinogenesis 57(5):664-677. doi: 10.1002/mc.22791ImpactFactor 4.18
  16. Pavithra PS, Alka Mehta and Rama S Verma (2018) Aromadendrene oxide 2, induces apoptosis in skin epidermoid cancer cells through ROS mediated mitochondrial pathwayLife SciencesVolume 197 (March 15) 19–29 doi.org/10.1016/j.lfs.2018.01.029 Impact Factor 2.7    
  17. Pavithra PS, Alka Mehta and Rama S Verma (2017) Induction of apoptosis by essential oil from P.missionis in skin epidermoid cancer cells Phytomedicinedoi.org/10.1016/j.phymed.2017.11.004ImpactFactor: 3.5 Citation: 1
  18. Santosh Gupta, Piyush Kumar Gupta, G. Dharanivasan, Rama Shanker VermaCurrent prospects and challenges of nanomedicine delivery in prostate cancer therapy (2017) Nanomedicine 12(23): 2675-2692. doi: 10.2217/nnm-2017-0236.ImpactFactor: 4.7
  19. Santosh Gupta, Vineeta Sharma, Rama Shanker Verma (2017) Recent Advances in Induced Pluripotent Stem Cell (iPSC) based TherapeuticsJournal of Stem Cell Research & Therapeutics 3 (3) 00100 DOI: 10.15406/jsrt.2017.03.00100
  20. Hema Priyamvada, Raj Kamal Singh, Akila M, Ravikrishna R, Rama Verma, and Sachin Gunthe (2017) Seasonal variation of the dominant allergenic fungal aerosols – One year study from southern Indian region Nature Scientific Report7(1), 11171Impact factor 4.3
  21. Akhil Pratap Singh, Devilakshmi Sithambaram, Rutvi Sanghavi, Piyush Kumar Gupta, Rama Shanker Verma, Mukesh Doble, Ramesh L. Gardas B  and  Sanjib Senapati (2017) Environmentally benign Tetramethylguanidinium cation based ionic liquids New Journal of Chemistry DOI: 10.1039/c7nj03167j Impactfactor: 3.269
  22. Raj Pranap Arun, Divya Sivanesan, Prasanna Vidyasekar, Rama Shanker Verma (2017) TEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity Nature Scientific ReportJul 20;7(1):5952.DOI:10.1038/s41598-017-06416-4 Impact Factor 4.3, Citation 01
  23. Antara Banerjee, Surajit Pathak, Vimala Devi S, Dharani Vasan, Ramachandran Murugesan and Rama S Verma (2017) Strategies for targeted drug delivery in treatment of colon cancer – current trends and future perspectives Drug Discovery Today (10.1016/j.drudis.2017.05.006)Impact Factor: 6.369Citation: 1
  24. Jahnavi S, Arthi N, Pallavi S, Selvaraju C, Bhuvaneshwar G S, Kumary T V, Rama Verma(2017) Nanosecond Laser Ablation Enhances Cellular Infiltration in a Hybrid Tissue Scaffold Materials Science & Engineering C 77 190–201.ImpactFactor: 4.164
  25. Swati Choudhary, Stefan Barth, Rama S Verma (2017) SNAP tag technology: a promising tool for ex vivo immunophenotyping”, Molecular Diagnosis & Therapy. (doi: 10.1007/s40291-017-0263-2)Impact factor 1.9 Citation 01
  26. Madumathi J., Sridevi S and Rama S Verma (2017)CD25 targeted therapy of chemotherapy resistant leukemic stem cells using DR5 specific TRAIL peptide Stem Cell Research DOI:10.1016/j.scr.2017.01.001Impact Factor 3.49 Citation 01
  27. S Jahnavi, U Saravananb, N Arthia, G S Bhuvaneshwarc, T V Kumaryd, S Rajane, R S Verma(2017) Biological and mechanical evaluation of a Bio-Hybrid scaffold for autologous valve tissue engineering Materials Science and Engineering: C Vol 73 (1), 59–71 org/10.1016/j.msec.2016.11.116ImpactFactor: 4.2, Citation 02
  28. Priyamvada H, Akila M , Raj Kamal Singh, Ravikrishna R, Verma R.S., Ligy Philip, Rahul Marathe, Sudheer K.P. and Gunthe S. S.(2017) Terrestrial macrofungal diversity from the tropical dry evergreen biome of southern India and its potential role in aerobiology PLOS ONE , 1-21Impact factor 4.411 Citation 04
  29. А. М. Айзенштадт, М.А. Фролова, Т. А. Махова, В. Е. Данилов, Rama S. Verma (2017). Peculiarities of the methodological approach to studying the regularities of the effect of nanoparticles on human health in the production of nonmetallic nanomaterials for construction purposes- Kazan: Publishing houseАН РТ, 2017, с. 299-302.
  30. A M Ayzenshtadt, M A Frolova, T A Makhova, V E Danilov, Piyush K. Gupta and Rama S. Verma (2017) Specifics of the methodological approach to the study of nanoparticle impact on human health in the production of non-metallic nanomaterial’s for construction purposes / IOP Conference Series: Earth and Environmental Science (EES) 107 (1), 012048
  31. Singh AP, D Sithambaram, Sanghavi R Gupta PK, Verma RS, Doble Mukesh and Senapati S (2017) Environmentally benign tetramethylguanidium cation based ionic liquid New Journal of Chemistry 41 (20) 12268-12277 Impact factor
  32. Pavithra Shyamsunder, Milan Esner, Maunish Barvalia, Yu Jun Wu, Tomáš Loja, Huat Bay Boon, Matilde E. Lleonart, Rama S Verma, Lumir Krejci, and Alex Lyakhovich (2016) ROS-mediated defective mitophagy in Fanconi anemia is dependent on mitochondrial fission Oncotarget 7, (36) 58065 doi: 10.18632/oncotarget.11161 Impact Factor 6.4 Citation 06
  33. Rama S. Verma (2016) Breaking dogma for future therapy using stem cell – Where we have reached? Indian J Med Res 143, February 2016, pp 125-25 Citation: 1
  34. Ponnusamy Ponmurugan, Ganesan Ayyappadasan, Rama Shankar Vermaand Sanjeeva Nayaka (2016) Survey, distribution pattern and elemental composition of lichens in. Yercaud hills of Eastern Ghats in southern India. Journal of Environmental Biology37, 407-412
  35. Arkady Ayzenstadt, Maria Frolova, Tatiana Mahova, Liudmila Veshniakova, Rama S. Verma (2016). Integrated Approach to the Assessment of quality system of Highly Dispersed silica Containing rocks 16th International Multidisciplinary Scientific Geoconference SCEM 2016: Nano, bio and green-technologies for a sustainable future, , Volume III, p.p. 53-61.
  36. Madhumathi J, Sridevi S and Rama S Verma (2016) Novel TNF-related apoptotic inducing ligand based immunotoxin for therapeutic targeting of CD25 positive leukemia Targeted Oncology 11(4), 535-547Impact Factor 4.0 Citation 05
  37. Dilip bishi,Santosh Mathapati, Jayarama R. Venugopal, Soma Guhathakurta, Kotturathu M. Cherian, Rama S. Verma and Seeram Ramakrishna(2016) A Patient-inspired Ex Vivo Liver Tissue Engineering Approach with Autologous Mesenchymal Stem Cells and Hepatogenic Serum Advanced Healthcare Materials5 (9) 1058–1070 Impact Factor 5.8 Citation 06
  38. Swati Choudhary, Alessa Pardo, Reinhard Rosinke, Janendra K Batra, Stefan Barth andRama S Verma (2016) Targeting c-kit receptor in neuroblastomas and colorectal cancers using Stem Cell Factor (SCF)-based recombinant bacterial toxins Applied Microbiology and Biotechnology Jan;100(1):263-77IF 3.81Citation: 4
  39. Prasanna Vidyasekar, Pavithra Shyamsunder, Sanjeeb Kumar Sahoo and Rama Shanker Verma (2016) Scaffold free and scaffold assisted 3-Dimensional culture enhances differentiation of bone marrow stromal cells,” In Vitro Cellular & Developmental Biology – Animal. Feb;52(2):204-17, PMID: 26542170Citation 03
  40. Jincy Joy, Amlan Gupta, Sarvepalli Jahnavi, Rama S Verma, Alok R Ray and Bhuvanesh Gupta,(2016) Understanding the in situ cross linked gelatin hydrogel Polymer International 65 (2),181–191: IF 2.4Citation 02
  41. Morphological characteristics of bioaerosols from contrasting locations in southern tropical India – A case study (2015) Aswathy E. Valsan, Hema Priyamvada, R. Ravikrishna, Viviane R. Despres, C.V. Biju, Lokesh K. Sahu, Ashwini Kumar, R.S. Verma, L. Philip, Sachin S. Gunthe Atmospheric Environment 122, 321–331 IF 3.28 Citation 09
  42. Sugapriya Dhanasekaran, Devilakshmi Sithambaram, Kavitha Govarthananan, Bijesh Biswal and Rama Verma (2015) An Efficient Protocol for Deriving Liver Stem Cells from Neonatal Mice: validating its Differentiation potential. Analytical Cellular Pathology Volume 2015:219206,
  43. Abhalaxmi Singh, Sumeet Jain, Shantibhusan Senapati, Rama Shanker Vermaand Sanjeeb K. Sahoo (2015) Magnetic Nanoparticles Labeled Mesenchymal Stem Cells: A Pragmatic Solution toward Targeted Cancer Theranostics Advanced Healthcare Materials DOI:10.1002/adhm.201500343IF 5.8 citation 01
  44. Prasanna Vidyasekar, Pavithra Shyamsunder, Rajpranap Arun,Rajalakshmi Santhakumar, Nand Kishore Kapadia, Ravi Kumar, RamaShanker Verma (2015) Genome Wide Expression Profiling of CancerCell Lines Cultured in Microgravity RevealsSignificant Dysregulation of Cell Cycle andMicroRNA Gene NetworksPLOS ONEAug 21;10(8):e0135958, DOI:10.1371/journal.pone.0135958IF 3.73 Citation 13
  45. Prasanna Vidyasekar, Pavithra Shyamsunder, Rajalakshmi Santhakumar, Rajpranap Arun, Rama Shanker Verma (2015) A simplified protocol for the isolation and culture of cardiomyocytes and progenitor cells from neonatal mouse ventricles European Journal of Cell Biology94(10):444-52: IF 3.82 Citation 07
  46. Madhumathi J, Devilakshmi S. and Verma R. S.(2015) Immunotoxin therapy for hematologic malignancies: where are we heading?Drug Discovery TodayFeb; 21(2):325-32.IF 5.96 Citation 09
  47. Jahnavi S., Kumary T.V., Bhuvaneshwar G.S., Natarajan T.S., and Verma R. S. (2015) Engineering of a polymer layered bio-hybrid heart valve scaffold. Materials Science and Engineering C51:263-737 Citation 12
  48. Parameswaran S, Santhakumar R, Vidyasekar P, Verma RS (2015)Enrichment of cardiomyocytes in primary cultures of murine neonatal hearts.  Methods Mol Biol 1299:17-25Citation 05
  49. Pavithra Shyamsunder, Rama S. Verma, and Alex Lyakhovich (2015) ROMO1 regulates Redox states and serves as an inducer of NF-kappaB-driven EMT factors in Fanconi anemia Cancer letters361(1):33-8.IF 5.01 citation 09
  50. Viswambari Devi R., Doble M., and Verma S Rama (2015) Nanomaterials for early detection of cancer biomarker with special emphasis on gold nanoparticles in immunoassays/sensors. Biosensors and Bioelectronics Jan 29;68C:688-698IF 6.5 Citation 56
  51. Rajalakshmi Santhakumar, Prasanna Vidyasekar, Rama Shanker Verma (2014)Cardiogel: A Nano-Matrix Scaffold with Potential Application in CardiacRegeneration UsingMesenchymal Stem Cells PLoS ONE 9(12): e114697.doi:10.1371/journal.pone.0114697IF 3.73 citation 15
  52. Alex Epanchintsev, Pavithra Shyamsunder, Rama S. Verma, andnAlex Lyakhovich (2014) IL-6, IL-8, MMP-2, MMP-9 are overexpressed in Fanconi Anemia Cells through a NF-kB/TNF-a Dependent MechanismMolecular Carcinogenesis DOI 10.1002/mc.22240IF 4.77 Citation 20
  53. Giovanni Pagano, Pavithra Shyamsunder, Rama S. Verma, Alex Lyakhovich. Damaged mitochondria in Fanconi anemia – an isolated event or a general phenomenon? Oncoscience. 2014;1:287-295.Citation 10
  54. Dillip Kumar Bishi, Santosh Mathapati, Kotturathu Mammen Cherian, Soma Guhathakurta and RamaShanker Verma (2014) In Vitro Hepatic Trans-Differentiation of HumanMesenchymal Stem Cells Using Sera from Congestive/Ischemic Liver during Cardiac Failure Plos One: 8;9(3):e92397. doi: 10.1371/journal.pone.0092397. Citation 12
  55. Pavithra Shyamsunder, Kripa S Ganesh, Prasanna Vidyasekar, Sheila Mohanand Rama Shanker Verma (2013) “Identification of Novel target Genes involved in Indian Fanconi Anemia patients using microarray” Gene Dec 1;531(2):444-50 10.1016/j.gene.2013.08.082IF 2.19 citation 06
  56. Sreejit Parameswaran, Sujeet Kumar, Rama Shanker Verma, Rajendra K Sharma( 2013) “Cardiomyocyte culture – an update on the in vitro cardiovascular model and future challenges” Canadian Journal of Physiology and Pharmacology91 (12), 985-998 IF 1.54 citation 27
  57. Pavithra Shyamsunder, Prasanna Vidyasekar, Akshay Ranjan Shukla, Sheila Mohan, and Rama Shanker Verma (2013) Lowered Expression Levels of a Tumor Supresser Gene- Caveolin-1 Within Dysregulated Gene Networks of Fanconi Anemia Gene Sep 25;527(2)521–528IF 2.19 citation 12
  58. Dillip Kumar Bishi, Santosh Mathapati, Jayarama Reddy Venugopal, Soma Guhathakurta, Kotturathu Mammen Cherian, Rama Shanker Verma,Seeram Ramakrishna (2013) Trans-differentiation of Human Mesenchymal Stem Cells Generates Functional Hepatospheres on Poly(L-lactic acid)-co-poly(ε-caprolactone)/collagen Nanofibrous Scaffolds Journal of Materials Chemistry B 132: 3871 4034IF 5.96 Citation 24
  59. Sreejit P and Verma, Rama Shanker (2013) Enhanced Cardiomyogenic Lineage Differentiation of Adult Bone Marrow Derived Stem Cells grown on Cardiogel Cell and Tissue ResearchSep;353(3):443-56. DOI: 10.1007/s00441-013-1661-3 67 Citation 13
  60. Sugapriya Dhanasekaran, Bijesh Biswal, Venil Sumantran and Rama S Verma (2013)Augmented Sensitivity to Methotrexate by Curcumin induced overexpression of Folate Receptor in KG-1 Cells Biochimie95(8): 1567-73. IF 3.02 Citation 16
  61. Mathapati S, Bishi DK, Guhathakurta S, Cherian KM, Venugopal J, Ramakrishna S, Verma R. S.(2013) Nanofibers-coated acellular tissue-engineered bovine pericardium supports differentiation of mesenchymal stem cells into endothelial cells for tissue engineering. Nanomedicine 9(5):623-34IF38 Citation 11
  62. Mrudula Mathew, Zaineb K.C., Rama Shanker Verma(2013)GM-CSF-DFF40: A Novel HumanizedImmunotoxin Induces Apoptosis in Acute Myeloid Leukemia cellsApoptosis18 (7) 882-895; Impact Factor 4.77 Citation 16
  63. Sreejit P& S. Verma(2013) Natural ECM as Biomaterial for Scaffold Based CardiacRegeneration Using Adult Bone Marrow Derived Stem CellsStem Cell Rev and Rep9(2); 158-71 Impact Factor 3.74 Citation 3
  64. Santosh Mathapati, Dillip Kumar Bishi1, Soma Guhathakurta, Kotturathu Mammen Cherian, Jayarama Reddy Venugopal, Seeram Ramakrishna, Rama Shanker Verma (2012) Biomimetic acellular detoxified glutaraldehyde cross-linked bovine pericardium for tissue engineering
Materials Science and Engineering Materials for Biological Applications33; 1561-1572, Impact Factor 2.68 Citation 23
  65. Muthumanickam Andiyappan, Subramanian Sundaramoorthy, Prasanna Vidyasekar , Natarajan Tirupattur Srinivasan  and Rama Shanker Verma(2012) Characterization of electrospun fibrous scaffold produced from Indian eri silk fibroin International Journal of Materials Research5; 498-506Citation 1
  66. Sreejit P, Bishi, Dillip K and Verma, Rama S (2012) Generation of mesenchymal stem cell lines from murine bone marrow Cell and Tissue Research350(1), 55-68.Impact Factor 3.67 Citation 22
  67. Madhumathi J and Verma RS (2012) Therapeutic Targets and Recent Advances in Protein Immunotoxins Current opinion inMicrobiology 15, 300–309ImpactFactor 7.92 citation 62
  68. Sandip Madhusudan Swain, Sreejit Parameswaran, Giriraj Sahu, Rama Shanker Verma and Amal Kanti Bera (2012) Proton-gated ion channels in mouse bone marrow stromal cells Stem Cell Research9, 59–68Impact Factor 5.12 Citation 10
  69. Anjana, D., K. Anitha Nair, N. Somashekara, M.Venkata, R. Sripathy, Rajesh Yelucheri,H. Parmar, R. Upadhyay, Rama Verma and C.N. Ramchand (2012) Development of Curcumin Based Ophthalmic Formulation American Journal of Infectious Diseases 8 (1): 41-49Citation 10
  70. Venkata, M., R. Sripathy, D. Anjana, N. Somashekara, A. Krishnaraju, S. Krishanu, M. Murali, Rama Verma and C.N. Ramchand (2012) In Silico, In Vitro and In Vivo Assessmentof Safety and Anti-inflammatory Activity of CurcuminAmerican Journal of Infectious Diseases 8 (1): 26-33Citation 09
  71. Moutushy Mitra, Mallikarjuna Kandalam, Anju Harilal, Rama Shenkar Verma, UmaMaheswari, S. Swaminathan, Subramanian Krishnakumar (2012) EpCAM is a putative stem marker in retinoblastoma and aneffective target for T-cell-mediated immunotherapy Molecular Vision 17;18: 290–308.Impact Factor 2.54 Citation: 25
  72. Chandana Tekkatte, Prasanna Vidyasekar, Nand Kishore Kapadia and Rama S Verma(2012) “Enhancement of adipogenic and osteogenic 1 differentiation of human bone marrow derived mesenchymal stem cells with umbilical cord blood serum supplementation Cell and Tissue Research347(2) 383-395Impact Factor 3.11Citation 
  73. Sithanbaram Devilakshmi, Palanivelu Shanthi, subramanian Krishnakumar Sahoo Sanjeeb and Verma Rama S (2011) “Monoclonal Antibody for Specific Targeting of Ep-CAM in Various Carcinomas” Hybridoma Volume 30, Number 6,511-518Impact Factor 0.462Citation 4
  74. Sreejit P and Verma R. S. (2011) Scanning Electron Microscopy Preparation Protocol For Differentiated Stem Cells Analytical Biochemistry 15;416(2): 186-90Impact Factor 3.256 citation: 21
  75. Swati Choudhary, Mrudula Mathew and Rama S. Verma(2011) “Therapeutic potential of anticancer immunotoxins”Drug Discovery Today(2011), 16 (11/12), 495-503Impact Factor: 7.25 Citation: 77
  76. Mitra Moutushy, Kandalam Mallikarjuna, Sundaram, C,Verma Rama, Maheswari Uma, Swaminathan S, Subramanian Krishnakumar (2011)”Reversal of stathmin mediated microtubule destabilization sensitizes retinoblastoma cells to low dose of anti microtubule agents: A novel synergistic therapeutic intervention Invest Ophthalmol VisJul 23;52(8):5441-8.Impact Factor 3.56 Citation: 20
  77. Sreejit P and R S Verma (2011)”Cardiogel supports adhesion, proliferation and differentiation of stem cells with increased oxidative stress protection” EuropianCell and Material Jourrnal (eCM)21: 107 – 121Impact Factor 9.36 Citation:18
  78. Santosh Mathapati, Rama Shanker Verma, Kotturathu Mammen Cheriana and Soma Guhathakurta (2011) Inflammatory responses of tissue-engineered xenografts in a clinical Scenario Interactive Cardio Vascular and Thoracic Surgery12:360-365 Impact Factor 2.19 citation 16
  79. Potala Sirisha and Verma Rama S (2011) Targeting head and neck squamous cell carcinoma using a novel fusion toxin-diphtheria toxin/HN-1. Molecular Biology Report 38(2):1389-97. Impact Factor: 2.92citation 09
  80. Potala Sirisha and Verma Rama S (2010) Modified DT-IL2 fusion toxin targeting uniquely IL2R alpha expressing leukemia cell lines-Construction and characterization.Journal of Biotechnology148,147-155 Impact Factor: 3.22Citation: 10
  81. Moutushy Mitra, Fahima Dilnawaz, Ranjita Misra, Anju Harilal, Rama Shanker Verma, Sanjeeb K. Sahoo and Subramanian Krishnakumar (2010) Toxicogenomics of nanoparticulate delivery of etoposide: potential impact on nanotechnology in retinoblastoma therapy Cancer Nanotechnology 2,1-6Citation 6
  82. Santosh Mathapati, Satish Galla, Rama Shanker Verma, Kotturathu Mammen Cherian, Soma Guhathakurta (2010) Qualitative and Quantitative Detection of Sodium Deoxycholic Acid in Decellularized Tissue.  Ind J of Thoracic Cardiovascular Surgery(2010) 26:129–131Citation 02
  83. Moutushy Mitra, Mallikarjuna Kandalam, Rama Shanker Verma, Uma Maheswari and Subramanian Krishnakumar (2010) Genome wide Changes accompanying the knockdown of EpCAM in retinoblastoma. Molecular vision16:828-84. Impact Factor: 2.54: Citation:20
  84. Sirisha Potala and Rama S Verma (2010) A novel fusion protein Diphtheria Toxin-Stem Cell Factor (DT-SCF) – purification and characterization. Applied Biochemistry and Biotechnology 162(5): 1258-69Impact Factor: 1.87: Citation:02
  85. Bijesh K Biswal, Niladri B. Debata and Rama S Verma (2010) Development of a targeted siRNA delivery system using FOL-PEG-PEI conjugate”. Molecular Biology Reports 37 (6) 2919-2926 Impact Factor: 2.92: Citation:35
  86. Pavithra P. S. Jannani S., Charumathi R., Indumathi J., and Verma Rama S. (2010) “Antibacterial activity of Plants Used in Indian Herbal Medicine. International Journal of Green Pharmacy 4 (1), 22-29: Citation: 67
  87. Santosh Mathapati, Sarasa Bharati Arumugam, Rama Shanker Verma (2010) “High cholesterol diet increases MMP9 and CD40 immunopositivity in early atherosclerotic plaquein rabbits”. Acta histochimica, 112, 618-623Impact Factor: 1.82Citation: 13
  88. Sunnel R, Dillip K Bishi, Rama S Verma, Kothurattu M Cherian and Soma Guhathakurta (2009) A multiplex PCR for characterization of human mesenchymal stem cells. Biotechnology Letter 31(12): 1843-50. Impact Factor: 1.68: Citation 11
  89. Pavithra S, N.Sreevidya,Rama S Verma (2009) Antibacterial and antioxidant activity of methanol extract of Evolvulus nummularius (L). Indian Journal of pharmacology vol. 41(5) 233-236 Impact Factor: 0.69 Citation: 20
  90. Bijesh K Biswal, K. Manniledam,Rama S Verma and E.Prasad (2009) Tumor Cell Imaging Using the Intrinsic Emission from PAMAM Dendrimer: A Case Study with HeLa Cells. Cytotechnology 61(1-2): 17-24: Impact Factor: 1.75: Citation: 13
  91. Bijesh K Biswal and Rama S Verma (2009) “Differential Usage of theTransport Systems for Folic acid and Methotrexate in Normal Human T-Lymphocytes and Leukemic Cells”. The Journal of Biochemistry146(5), 693–703 Impact Factor: 2.14 Citation: 8
  92. Chandana Mohanty, Geetanjali Arya, Rama S Verma and Sanjeeb K Sahoo (2009) Nanobiotechnology: Application of Nanotechnology in Therapeutics and Diagnosis Journal of Nano biotechnology: biomedicine1(1), B24 – B38. Citation:08
  93. Mrudula Mathew and Rama S. Verma (2009) Humanized Immunotoxins – A New Generation of Immunotoxins Cancer Sciences 100, (8), 1359-1365: Impact factor: 47: Citation:122
  94. Pavithra P S., Sreevidya N. and Rama S Verma (2009) Antibacterial activity and chemical composition of essential oil of Pamburus missionis Journal of Ethanopharmacology 124(1) 151-153: Impact Factor: 3.01: Citation:24
  95. Pavithra P S., Sreevidya N. and Rama S Verma (2009) A review of chemistry and biological activity of genus Atalantia (Rutaceae) Journal of Medicinal and Aromatic Plant Science31,63-72.Impact Factor: 2.26:Citation: 02
  96. Himabindu, D. Sugapriya Muthamilselvan, Dillip Kumar Bishi, and Rama S Verma (2009) Molecular Analysis of Coagulase Gene Polymorphism in Clinical Isolates of Methicilin Resistant Staphylococcus Aureus By Restriction Fragment Lenth Polymorphism Based Genotyping American Journal of Infectious diseases 5(2):170-176 Citation 21
  97. Pavithra P.S, Sreevidya N and Rama S Verma (2009) Antibacterial and antioxidant activity of methanol extract of Evolvulus nummularius (L). Indian Journal of pharmacology vol. 41(5) 233-236 Citation: 13
  98. Dillip kumer Bishi, Ilu Vargheese and Rama S. Verma (2008) “Molecular typing of colonizing Streptococcus agalactiae strains by Enterobacterial Repetitive Intergenic Consensus PCR (ERIC-PCR) in a Chennai based hospital” Indian journal of Microbiology 48: 291-296. Impact Factor: 9 Citation: 1
  99. Sirisha potala, Sanjeeb Sahoo and Rama S. Verma (2008) “Targeted therapy of cancer using Diphtheria toxin derived immunotoxins” Drug discovery Today Review 13, 17/18,807-815.Impact Factor: 7.7: Citation:54
  100. Rallapalli S, S Verghese and Verma R S(2008) Validation of Multiplex PCR strategy for simultaneous detection and Identification of methicillin resistance staphylococcus Aureus Indian Journal on Medical Microbiology 26 (4) 360-363 Impact Factor: 1.006 Citation: 25
  101. Sreejit P., Suresh Kumar and Rama S. Verma (2008) An Improved Protocol for Primary Culture of Cardiomyocytes from Neonatal Mice In-Vitro Cellular and Developmental Biology – Animal 44, 45-50.Impact Factor: 312: Citation:106
  102. Kalidoss Ramamoorthy, Sirisha Potala, and Rama S. Verma(2008) Convergence pattern studies of folate receptor Boinformation 3(4): 168-172 (2008). Impact Factor: Citation:
  103. Kalidoss Ramamoorthy, Sirisha   Potala, and Rama S. Verma (2007) Insilico analysis of functionally important residues in folate receptors. Bionformation 2 (4), 157-162Impact Factor: Citation:5
  104. Taichman R. S., Reilly M. J., Verma R. S., Ehrenman K. and Emerson S. G(2001) Hepatocyte Growth Factor is Secreted by Osteoblast and Cooperatively Permits tge survials of Haematopoietic Progenators British Journal of Haematology 112(2) 438-448. Impact Factor: 47 Citation:95
  105. Verma R.S., Gianolla D., Schomichik W., and Emerson S. G (1998) Increased efficiency of liposime‑mediated transfection by volume reduction and centrifugation Biotechniques 25(1): 46-49.Impact Factor: 2.3: Citation: 17
  106. Taichman R.S., Reilly M.J., Verma R.S., and Emerson S.G.(1997) Augmented production of interleukin‑6 by normal human osteoblasts in response to CD34+ hematopoietic bone marrow cells in vitro Blood 15: 89(4), 1165‑1172. Impact Factor: 10.37: Citation: 69
  107. Natarajan V., Vepa S.,Verma R. S., and Scribner W. M.(1996) Role of Protein Tyrosine Phosphorylation on H202‑lnduced Phospholiase D Activation of Endothelial Cells Phospholipase D. American J. Physiol – Lung Cellular and Molecular Physiology 271 no. 3, L400-L408.Impact factor: 4.08: Citation: 64
  108. Verma, R. S., and Antony, A. C. (1992) Immunoreactive folate‑binding proteins from human saliva: isolation and comparison of two distinct species.Biochem. J. 286: 707‑715. Correction Biochem J 289: 927‑928. (1993)Impact Factor: 4.349: Citation: 15
  109. Verma, R. S., Gullapalli, S., and Antony, A. C. (1992) Evidence that the hydrophobicity of isolated in situ and de novo synthesized native human placental folate receptor is a function of glycosylphosphatidylinositol anchoring to membranes. J. Biol. Chem. 267:4119‑4127. Impact Factor: 7.66: Citation: 59
  110. Verma, R. S., and Antony, A.C.(1991) Kinetic analysis, isolation and characterization of hydrophilic folate‑binding protein released from chorionic villi cultured under serum free conditions. J. Biol. Chem. 266:12522‑12535.Impact Factor: 7.66: Citation: 10
  111. Verma, R. S., and Antony, A. C.(1991) Kinetic isolation and characterization of soluble (s) folatebinding protein (flop) released from human placental chorionic villi‑associated hydrophobic FBP (M‑FBP) in serum free culture. Clinical Research, 39(2):205a Impact Factor: 0.159:
  112. Antony, A. C., Briddell, R. A., Brandt, J. E., Straneva, J. E., Verma, R. S., Miller, M. E., Kalasinski, L. A., and Hoffman, R. (1991) Megaloblastic hematopolesis in vitro: interaction of anti‑folate receptor antibodies with hematopoletic cells leads to a proliferative response independent of megaloblastic changes J. Clin. Invest. 87: 313‑325.Impact Factor: 92: Citation: 23
  113. Antony, A. C., Kane, M., Kincade, S., Briddell, R., and Verma, R. S. (1989) Folate (pteroylglutamate) uptake in human erythrocytes, erythroid precursors and kb cells at high extra cellular folate concentrations: evidence against a specific folate‑binding and transport protein. Biochem. J. 260:401- 411. Impact Factor: 349: Citation: 22
  114. Antony, A. C., Verma, R. S., Unune, A. R., and Larosa, J. A.(1989) Identification of hydrophobic folate binding forms. J. Biol. Chem. 264:1911‑1914.Impact Factor: 7.66: Citation: 32
  115. Antony, A. C., and Verma, R. S. (1989) Hydrophobic erythrocyte folate‑binding proteins are converted to hydrophilic forms by trypsin in vitro. Biochem. Biophys. Acta. 979:62‑68.Impact Factor: 3.36: Citation: 7
  116. 102.Verma, R. S.,Kincade, R. S., and Antony, A. C.(1988) Isolation and characterization of two distinct immunoreactive folate binding proteins from human saliva. Clinical Research. 36(3):360.Impact factor:  0.195: Citation: 37
  117. Antony, A. C., Bruno, E., Briddell, R., Brandt, J., Verma, R. S., and Hoffman, R. (1987) Effect of perturbation of specific folate receptor during in vitro erythropoiesisJ. Clin. Invest. 80(6):1618‑1623. Impact Factor: 10.92: Citation: 42
  118. Panday, R., Verma, R. S. and Khullar, G. K. (1987) Effect of choline, ethanolamine and serine supplementation on the membrane properties of mycosporum gypsum. Lipids. 22(7): 530‑534. Impact Factor: 2.040
  119. Antony, A. C., Bruno, E., Bridell, R., Brandt, J., Verma, R. S., and Hoffman, R. (1987) Evidence for a role for folate receptor during in vitro erythropolesis. Clinical research 35(3):569. Impact Factor: 0.195
  120. Antony, A. C., Kincade, S., Verma, R. S., And Krishnan, S. R. (1987) Identification of high affinity folate binding protein in human erythrocyte membrane. J. Clin. Invest. 80:711‑723. Impact Factor: 10.92: Citation: 38
  121. Verma, R. S., Spencer‑martin, I., and Van uden, N. (1987) Role of de novo protein synthesis in the inter conversion of glucose transport systems in the yeast Pichia ohmeri. Biochem. Biophys. Acta. 900:139‑144.Impact Factor: 3.36: Citation:22
  122. Antony, A. C., Verma, R. S., and Knicade, R. S. (1987) Development of a specific radio‑immunoassay of’ the placental folate receptor and related high affinity folate binding protein in human tissues. Anal. Biochem. 162:224‑235.Impact Factor: 2.149: Citation: 12
  123. Verma, R. S., Rao, T. V. G., and Prasad, R. (1984) An inducible, specific and derepressible transport of L‑series in saccharomyces cerevisiae. Biochem. Biophys. Acta. 778:289‑297.Impact Factor:  3.36: Citation: 22
  124. Verma, R. S.(1984) Amino Acid Transport in Yeast. Ph.D. Thesis Jawaharlal Nehru University New Delhi 110067, India
  125. Rao, T. V. G., Verma, R. S., and Prasad, R. (1983) Transport of purine, pyrimidine bases and nucleosides in candida albicans, a pathogenic yeast. Biochem. Int. 6:409‑416.Citation: 18
  126. Verma, R. S., and Prasad, R. (1983) Absence of depression of amino acids transports in candida. Biochem. Int. 7:707‑717.Citation:15
  127. Prasad, R., Jayakumar, A., Singh, M., Trivedi, A., Khare, S., Verma, R. S., Rao, T. V. G., and Dudani, A. K. (1983) Amino acid transport in yeast. In: proceedings of symposium on the role biochemistry in harnessing the environment, Indian Toxicological Research Center, Lucknow, India 8 (No. 1‑2), Pp. 31‑43.
  128. Verma, R. S., and Prasad, R. (1983) Amino acid transport in whole cell and membrane vesicles of saccharomyces cerevisiae. In: proceedings of viii international specialized symposium on yeast, Baroda, India.
  129. Verma R. S., and Prasad, R. (1983) Characteristics of amino acid transport in deficient (rhoO) mutant cells. Ind. J. Biochem. Biophys. 20:104‑109. Impact Factor: 0.45Citation: 1
  130. Jayakumar, A., Singh, M., Verma, R. S., Baquer, N. Z., and Prasad, R. (1981) Characteristics of proline transport in the spheroplasts from candida albicans cells. Ind. J. Biochem. Biophys. 1 8:206‑210.. Impact Factor: 0.45Citation: 8

 

General, social and ethical topic

  1.   Rama S Verma and Sreejit P (2009) Culture and Morality Bulletin Chennai Academy for Science, Humanities and Religion 2(2) July 2009
  2.   Rama S Verma, Bijesh K. Biswal. Abhilasha, Chithra R and Sugapriya D. M. (2009) Innovation and Challenges in Biotechnology (ICICB-08) ISBN: 978-93-.80043-16-6

Text Books/ Monographs Authored/ Book Chapter

  1. Jahnavi Sarvepalli, Rajalakshmi Santhakumar and Rama Shanker Verma (2015) Evolving Concepts for Use of Stem Cells and Tissue Engineering for Cardiac Regenerationin Optimizing Assistive Technologies for Aging Populations Eds Morsi M, Shukla A and Rathore CP – A volume in the Advances in Medical Technologies and Clinical Practice (AMTCP) BookSeries IGI publication DOI: 10.4018/978-1-4666-9530-6.ch011
  2. Sithambaram Devilakshmi, Jayaprakasam Madhumathi and Rama Shanker Verma (2015) Immunotoxins, Resistance and Cancer Stem Cells: Future Perspective Resistance to Immunotoxins in Cancer Therapy (2015) Edited By Rama S Verma ISBN 978-3-319-17274-3 Springer Switerland
  3. Sreejit Parmeswaran, Rajlakshmi Santhakumar, Prasanna vidyasekar and Rama S Verma (2015) Enrichment of Cardiomyocytes in primary cuture of Neonatal heats Cardiomyocytes: Methods and Protocols (Methods in Molecular Biology) Springer Protocols: Editors Gary R Skuse and Maureen C Ferran ISBN-13: 978-1493925711 Human Press USA
  4. Pavithra Shyamsunder, Rama S. Verma, Sudit S. Mukhopadhyay and Alex Lyakhovich (2015) Involvement of Mitochondria in the Pathology of Fanconi Anemia Fanconi Anemia and Oxidative Stress: Mechanistic Background and Clinical Prospects ed by Nova Science Publisher USA
  5. Rama Shanker Verma, Sirisha Potala, Mrudula Mathew and Swati chaudhary (2012) Application of Microbial Toxins for Cancer Therapy T. Satyanarayana et al. (eds.), Microorganisms in Sustainable Agriculture and Biotechnology, DOI 10.1007/978-94-007-2214-9_28, © Springer Science Business Media B.V. 2012
  6. Prasanna Vidyasekar, Pavithra Shyamsunder, and Rama S Verma (2010) Nano-biotechnology: A new generation of biomedicine-Innovative nanotechnology in key areas of biomedical engineering and cancer therapy “Application Nanotechnology for Human Health” 2 (2), 237-254 by Dr. Sanjeeb K SahooPublisher CRC Press, Taylor and Francis Group Florida USA
  7. Rama S Verma, Abhilasha, Sugapriya M. D. and Chithra R. (2009) Animal biotechnology: application and potential risks in Biotechnology in Functional Foods and Nutraceuticals 14, 220- 250, Editor – Dr. Debasis Bagchai publisher- Taylor and Francis USA
  8. Denis English, Akshay Anand, Rama S. Verma and Stephan Gluck (2009) Neural Stem Cells: New Hope for Successful Therapy) Stem Cell and Regenerative Medicine, 8, 129-151 Editor- Dr. Herman S. Cheung (Ed.) Bentham Science Publishers Ltd. USA
  9. Prasanna Vidyasekar, Pavithra Shyamsunder, and Rama S Verma (2010) Nano-biotechnology: A new generation of biomedicine-Innovative nanotechnology in key areas of biomedical engineering and cancer therapy “Application Nanotechnology for Human Health” Ed. by Dr. Sanjeeb K Sahoo) Publisher – Pan Stanford, Italy (in Press)
  10. Rama Shanker Verma, Sirisha Potala, Mrudula Mathew and Swati chaudhary (2012) Application of Microbial Toxins for Cancer Therapy T. Satyanarayana et al. (eds.), Microorganisms in Sustainable Agriculture and Biotechnology, DOI 10.1007/978-94-007-2214-9_28, © Springer Science Business Media B.V. 2012
  11. Verma R.S. (2006) “Targeting Human growth factors, cytokines gene into Silkworms Muga silkworm” in Biochemistry, Biotechnology and Molecular Biology, Published at RRL Jorhat pp 204-211.