Books Published:

Karunagaran D,Subramanian M,Rao RS (2012).Regulation of MicroRNAs by Natural Compounds: Implications for Cancer Therapy.(Chapter 16).M. Diederich (ed.), Natural Compounds As Inducers of Cell Death: Volume 1,Springer Science+Business Media Dordrecht

Karunagaran, D., and Bharat Aggarwal (2003) Transcription factors as targets for drug development “In Pathomechanisms- New trends in drug research: Molecular mechanisms and new trends in drug development” Ed. Gyorgy Keri and Istvan Toth, Taylor and Francis, London and New York

Karunagaran, D. (2003) Relevance of Apoptosis to Cancer. In: Biotechnology: Emerging Trends. Joseph Selvin et al. (eds). Biotech Publishers, New Delhi

Karunagaran, D. and Goodwin Jinesh (2008). TGF-β, Smads and Cervical Cancer. In Transforming Growth Factor-Beta in Cancer Therapy Volume II Cancer Drug Discovery and Development Jakowlew, Sonia (Ed.) The Humana Press, Inc., NJ, USA.

Karunagaran, D. and Goodwin Jinesh(2005) Biotechnological approaches in the detection and treatment of cancer. In “Advances in Biotechnology” Ed. P. C. Trivedi, Agrobios (India), Jodhpur

D. Karunagaran, Jeena Joseph and T. R. Santhosh Kumar (2007) Cell Growth Regulation by Curcumin. In “The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease “ Advances in Experimental Medicine and Biology , Vol. 595 Aggarwal, Bharat B.; Surh, Young-Joon; Shishodia, Shishir (Eds.) ,Springer Publishers, New York.


Non-Peer Reviewed:

D. Karunagaran and S.Asha Nair (2001) Relevance of Rel signaling in cancer Amala Research Bulletin 21: 1-3

D. Karunagaran (2003) Fight against cancer continues, armed with novel biotechnological tools pp 68-74 In “ A Compendium on the Focal Theme of National Science Day” State Committee on Science, Technology and Environment, Government of Kerala

Cancer treatment: Novel biotechnological approaches, Kerala Calling, December 2003 18-20.

Transforming growth factor-b signaling in cancer (2004) Amala Research Bulletin 24: 12-17

Coercing cancer cells to commit suicide through molecular targeting. Advanced Biotech, October 2004, 15-18.

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Menadione Induced Reset of Circadian Superoxide Rhythms in Human Colon Cancer Cells

miR-214 activates TP53 but suppresses the expression of RELA, CTNNB1, and STAT3 in human cervical and colorectal cancer cells

microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells

Paspalum scrobiculatum polyphenol rich extracts inhibit human cervical cancer cell proliferation and induce apoptosis in vitro

microRNA-145 downregulates SIP1-expression but differentially regulates proliferation, migration, invasion and Wnt signaling in SW480 and SW620 cells

Reply: Comment on MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells


MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells

Downregulation of HMGB1 by miR-34a is sufficient to suppress proliferation, migration and invasion of human cervical and colorectal cancer cells

microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells


Advances in chalcones with anticancer activities

Discrimination of driver and passenger mutations in epidermal growth factor receptor in cancer

Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-κB activation induced by TNF-α concurrently increasing senescence and survival

Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells

MicroRNA-155 directly targets PDCD4 and activates BIC promoter through AP-1 dependent transcription to replenish miR-155 expression in SAS cells

Discrimination of driver and passenger mutations in epidermal growth factor receptor in cancer

Biochemical studies during germination of seeds of horse gram macrotyloma uniflorum Food reserve mobilization and its regulation


Evaluation of Cytotoxic and Anti-Tumor Activities of Coscinium fenestratum Extract

HPV16 E2 enhances the expression of NF-? B and STAT3 target genes and potentiates NF-? B activation by inflammatory mediators

Plumbagin downregulates Wnt signaling independent of p53 in human colorectal cancer cells

Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives

HPV16 E2-mediated potentiation of NF-κB activation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-induced apoptosis

MiR‐29b Downregulates Canonical Wnt Signaling by Suppressing Coactivators of β‐Catenin in Human Colorectal Cancer Cells

Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620

HPV16 E2 enhances the expression of NF-κB and STAT3 target genes and potentiates NF-κB activation by inflammatory mediators



John Victor, N., Sakthivel, R., Muraleedharan, K. M. and Karunagaran, D. (2013), N-Substituted 1,2-Dihydroquinolines as Anticancer Agents: Electronic Control of Redox Stability, Assessment of Antiproliferative Effects, and Mechanistic Insights. ChemMedChem, 8: 1623–1628.

Savita Udainiya and Devarajan Karunagaran (2013) MicroRNA-106b-25 cluster targets β-TRCP2, increases the expression of Snail and enhances cell migration and invasion in H1299 (Non Small Cell Lung Cancer) cells. Biochem. Biophys. Res. Commun., 434:841-7

Pushparathinam Gopinath, Krishnan Ramalingam, Kannoth Manheri Muraleedharan,Devarajan Karunagaran (2013) Benzisothiazolones arrest the cell cycle at the G2/M phase and induce apoptosis in HeLa cells.Med. Chem. Commun.,4, 749-752

B. Kumar, N., Dhurandhar, M., Aggarwal, B., Anant, S., Daniel, K., Deng, G., Djeu, J., Dou, J., Hawk, E., Jayaram, B., Jia, L., Joshi, R., Kararala, M., Karunagaran, D., Kucuk, O., Kumar, L., Malafa, M., Samathanam, G. J., Sarkar, F., Siddiqi, M., Singh, R. P., Srivastava, A. and White, J. D. (2013). Proceedings of the Indo-U.S. bilateral workshop on accelerating botanicals/biologics agent development research for cancer chemoprevention, treatment, and survival. CANCER MEDICINE, 2: 108–115.

Juneja, Manisha, Uma Vanam, Sripriya Paranthaman, Asha Bharathan, Venugopal S. Keerthi, Justus K. Reena, Rama Rajaram, Kallikat N. Rajasekharan, and Devarajan Karunagaran. (2013). 4-Amino-2- arylamino-5-indoloyl/cinnamoyl thiazoles, analogs of topsentin-class of marine alkaloids, induce apoptosis in HeLa cells. European Journal of Medicinal Chemistry, 63:474-483


Kavitha K, Vidya Priyadarsini R, Anitha P, Ramalingam K, Sakthivel R, Purushothaman G, Singh AK,Karunagaran D, Nagini S (2012).Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells.Eur J Pharmacol.15;681,6-14.

Karunagaran, D.,Maitreyi Subramanian and RaoSrinivasaRao (2012) Regulation of MicroRNAs by Natural Compounds: Implications for Cancer Therapy, In “Natural compounds as inducers of cell death” Edited by Mark Diederich, Springer Publishers.

Subramoniam A, Asha VV, Nair SA, Sasidharan SP, Sureshkumar PK, Rajendran KN, Karunagaran D, Ramalingam K (2012).Chlorophyll revisited: anti-inflammatory activities of chlorophyll a and inhibition of expression of TNF-α gene by the same.Inflammation.35;3,959-66.


Vidya Priyadarsini R, Senthil Murugan R, Maitreyi S, Ramalingam K, Karunagaran D, Nagini S (2010). The flavonoid quercetin induces cell cycle arrest and mitochondria mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur. J. Pharmacol., 649, 84-91.

Murugan RS, Priyadarsini RV, Ramalingam K, Hara Y, Karunagaran D, Nagini S. (2010) Intrinsic apoptosis and NF-κB signaling are potential molecular targets for chemoprevention by black tea polyphenols in HepG2 cells in vitro and in a rat hepatocarcinogenesis model in vivo. Food Chem. Toxicol., 48, 3281-7.

Sumith Retnamma Panicker, Prethish Sreenivas, Mani Sankar Babu, Devarajan Karunagaran and Chandrasekharan Cheranellore Kartha (2010) Quercetin attenuates Monocyte Chemoattractant Protein-1 gene expression in glucose primed aortic endothelial cells through NF-κB and AP-1. Pharmacol. Res., 62, 328-336.

Vidya Priyadarsini, R., Senthil Murugan, R., Sripriya, P., Karunagaran D and Nagini, S. (2010) The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells. Free Radic. Res., 44, 624-634.

Marie Lue Antony, Rema Nair , Paul Sebastian and Devarajan Karunagaran (2010) Changes in expression, and/or mutations in TGF-β receptors (TGF-β RI and TGF-β RII) and Smad 4 in human ovarian tumors J. Cancer Res. Clin. Oncol., 136, 351-361


Sivakumar, KC, Thomas B, and Karunagaran D (2009) Three dimensional structure of the closed conformation (active) of human merlin reveals masking of actin binding site in the FERM domain Int. J. Bioinformatics Research and Applications 5, 516-524

Paul BT, Babu MS, Santhoshkumar TR, Karunagaran D, Selvam GS, Brown K, Woo T, Sharma S, Naicker S, Murugesan R. (2009) Biophysical evaluation of two red-shifted hypocrellin B derivatives as novel PDT agents J. Photochem. Photobiol., 94, 38-44


Karunagaran D, Joseph J, Kumar TR. (2007)  Cell growth regulation, Adv. Exp. Med. Biol., 595, 245-268

Saja K, Babu MS, Karunagaran D, and Sudhakaran PR (2007) Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cells. Int. Immunopharmacol. 7, 1659-1667.


Shlomit Erlich, Pazit Tal-Or, Roy Blum, Yoel Kloog, Devarajan Karunagaran and Ronit Pinkas-Kramarski (2006) Ras Inhibition Results in Growth Arrest and Death of Androgen-Dependent and Androgen-Independent Prostate Cancer Cells. Biochem. pharmacol., 72, 427-436

John Mohan, Alankaram Arul Gandhi, Balan Chandrika Bhavya, Ramachandran Rashmi, Devarajan Karunagaran, Ramachandran Indu, and Thankayyan Retnabhai Santhoshkumar (2006) Caspase-2 triggers Bax-Bak dependent and independent cell death in colon cancer cells treated with resveratrol. J. Biol. Chem., 281, 17599-17611

Kumaraguruparan R, Karunagaran D, Balachandran C, Manohar BM, Nagini S (2006). Of humans and canines: A comparative evaluation of heat shock and apoptosis-associated proteins in mammary tumors. Clin Chim Acta. 365, 168-176


Manickam Venkatraman, Ruby John Anto, Asha Nair, Merina Varghese and Devarajan Karunagaran (2005) Biological and chemical inhibitors of NF-κB sensitize SiHa cells to cisplatin-induced apoptosis. Mol. Carcinogenesis 44, 51-59

D. Karunagaran, R. Rashmi and T. R. Santhosh Kumar (2005) Induction of Apoptosis by Curcumin and Its Implications for Cancer Therapy. Curr. Cancer Drug Targets 5, 117-129

Ramachandran Rashmi, Santhosh Kumar and Devarajan Karunagaran (2005) Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. Carcinogenesis 26, 713-723

Smitha V. Bava, Vineshkumar T. Puliappadamba, Ayswaria Deepti, Asha Nair, Devarajan Karunagaran, and Ruby John Anto (2005) Sensitization of Taxol-induced Apoptosis by Curcumin Involves Down-regulation of Nuclear Factor-κB and the Serine/Threonine Kinase Akt and Is Independent of Tubulin Polymerization. J. Biol. Chem., 280, 6301-6308


Ramachandran Rashmi, Santhosh Kumar and Devarajan Karunagaran (2004) Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their downregulation potentiates it. Carcinogenesis 25, 1867-1877

Tessy T Maliekal, Ruby John Anto and Devarajan Karunagaran (2004) Differential Activation of Smads in HeLa and SiHa Cells that Differ in their Response to Transforming Growth Factor-β. J. Biol. Chem., 279, 36287-36292

Suby Oommen, Ruby John Anto, Gopal Srinivas and Devarajan Karunagaran (2004) Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. Eur. J. Pharmacol. 485, 97-103

Ramachandran Rashmi, Santhosh Kumar and Devarajan Karunagaran (2004) Ectopic Expression of Hsp70 Confers Resistance, and Silencing Its Expression Sensitizes Human Colon Cancer Cells to Curcumin-induced Apoptosis. Carcinogenesis 25, 179-187


Tessy T Maliekal, Marie-Lue Antony, Asha Nair, Ramasamy Paulmurugan and Devarajan Karunagaran (2003) Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer. Oncogene 22, 4889-4897

Gopal Srinivas, Ruby John Anto, Priya Srinivas, Subramanian Vidhyalakshmi, Vijayamma Priya Senan and Devarajan Karunagaran (2003) Emodin induces apoptosis of human cervical cancer cells through poly (ADP-ribose) polymerase cleavage and activation of caspase 9. Eur. J. Pharmacol. 473, 117-125

Ruby John Anto, Manickam Venkatraman, and Devarajan Karunagaran (2003) Inhibition of NF-κB sensitizes A431 Cells to EGF-induced apoptosis whereas its activation by Ectopic expression of RelA confers resistance J. Biol. Chem. 278, 25490-25498

R. Rashmi, T. R. Santhosh Kumar, D. Karunagaran (2003) Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases FEBS Letters 538, 19-24

Asha Nair, Manickam Venkatraman, Tessy T. Maliekal, Balaraman Nair, and Devarajan Karunagaran (2003) Nuclear Factor-κB is Constitutively Activated in High grade Squamous Intraepithelial Lesions and Squamous Cell Carcinomas of the Human Uterine Cervix. Oncogene 22, 50-58.

Asha Nair, S., Karunagaran, D., and Sudhakaran, P. R. (2003) Changes in matrix metalloproteinases and their endogenous inhibitors during tumor progression in the uterine cervix. J Cancer Res Clin Oncol 129, 123-131

2002 Rabi T, Karunagaran D, Krishnan Nair M, Bhattathiri VN. (2002) Cytotoxic activity of amooranin and its derivatives. Phytother. Res. 1, S84-86
2000 Anto, R. J., Maliekal, T. T., and Karunagaran D. (2000) L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis J. Biol.Chem. 275, 15601-15604

Chen, H., Yu, D., Chinnadurai, G., Karunagaran, D. and Hung, M. C. (1997) Mapping of adenovirus 5 E1A domains responsible for suppression of neu-mediated transformation via transcriptional repression of neu. Oncogene 14, 1965-1971.

Kiyokawa, N., Karunagaran, D., Lee, E.K., Xie, Y., Yan, D-H., and Hung, M.C. (1997) Involvement of cdc2-mediated phosphorylation in the cell cycle-dependent regulation of p185 neu. Oncogene 15, 2633-2641.

Kiyokawa, N., Lee, E. K., Karunagaran, D., Lin, S-Y., and Hung, M.C. (1997) Mitosis-specific negative regulation of epidermal growth factor receptor triggered by a decrease in ligand binding and dimerization can be overcome by overexpression of receptor. J. Biol. Chem., 272, 18656-18665.

Shao, R., Karunagaran, D., Zhou, B. P., Li, K., Lo, S-S., Deng, J., Chiao, P., and Hung, M. C. (1997) Inhibition of nuclear factor - κB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis. J. Biol. Chem., 272, 32739-32742


Karunagaran, D., Tzahar, E., Beerli, R. R., Chen, X., Graus-Porta, D., Ratzkin, B., Seger, R., Hynes, N.E. and Yarden, Y. (1996) ErbB-2 is a common auxiliary subunit of NDF- and EGF-receptors: implications for breast cancer. EMBO.J.15: 254-264.

Chen, X., Levkowitz, G., Tzahar, E., Karunagaran, D., Lavi, S., Ben-Baruch, N., Leitner, O., Ratzkin, B. J., Bacus, S. S. and Yarden, Y. (1996) An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4. J. Biol. Chem. 271: 7620-7629.

Tzahar, E., Waterman, H., Chen, X., Levkowitz, G., Karunagaran, D., Lavi, S., Ratzkin, B.J. and Yarden, Y. (1996) A Hierarchial Network of Interreceptor Interactions Determines Signal Transduction by Neu Differentiation Factor/Neuregulin and Epidermal Growth Factor. Mol.Cell. Biol.16, 5276-5287.


Karunagaran, D., Tzahar, E., Liu, N., Wen, D. and Yarden, Y. (1995) Neu Differentiation Factor Inhibits EGF Binding: A Model for Trans-Regulation Within the ErbB Family of Receptor Tyrosine Kinases. J. Biol. Chem., 270, 9982-9990.

Lu, H.S., Chang, D., Philo, J. S., Zhang, K., Linda, O. N., Liu, N., Zhang, M., Sun, J., Wen, J., Yanagihara, D., Karunagaran, D., Yarden, Y. and Ratzkin, B. (1995) Studies on the Structure and Function of Glycosylated and Nonglycosylated neu Differentiation Factors: Similarities and differences of the α and β isoforms. J. Biol. Chem. 270, 4784-4791.

Marikovsky, M., Lavi, S., Pinkas-Kramarski, R., Karunagaran, D., Liu, N., Wen, D. and Yarden, Y. (1995) ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes. Oncogene, 10, 1403-1411.


Wen, D., Suggs, S. V., Karunagaran, D., Liu, N., Cupples, R. L., Luo, Y., Janssen, A. M., Ben-Baruch, N., Trollinger, D. B., Jacobsen, V. L., Meng, S-Y., Lu, H.S., Hu, S., Chang, D., Yanigahara, D. Koski, R.A. and Yarden, Y. (1994). Structural and Functional Aspects of the Multiplicity of Neu Differentiation Factors. Mol. Cell. Biol.14, 1909-1919.

Tzahar, E., Levkowitz, G., Karunagaran, D., Yi, L., Peles, E., Lavi.S., Chang, D., Liu, N., Yayon, A., Wen. D. and Yarden, Y (1994) ErbB-3 and ErbB-4 Function as the Respective Low and High Affinity Receptors of All Neu Differentiation Factor/Heregulin Isoforms. J. Biol. Chem. 269, 25226-25233.

1993 Dhanunjayanath, V., Karunagaran, D., and Ramakrishna Rao, P. (1993) Effect of fluoride on germination and starch mobilization of horse gram seeds. Indian J. Plant Physiol., 36:131-133.
1992 Karunagaran, D., Mohana, M.N and Usha, V. (1992).  Influence of axis on hydrolase development in cowpea (Vigna unguiculata L.) cotyledons during germination. Indian J. Plant Physiol., 35: 300-304.
1991 Karunagaran, D., and Ramakrishna Rao, P. (1991) Mode and control of starch mobilization during germination of seeds of horse gram. Plant Sci,, 73: 155-159.

Karunagaran, D. and Ramakrishna Rao, P. (1990) Development of mitochondria in horse gram cotyledons during germination. Indian J. Plant Physiol., 33: 219-225

Karunagaran, D. and Ramakrishna Rao, P. (1990) Axial control of protease development in cotyledons of horse gram (Macrotyloma uniform Lam.) seeds during germination. Indian J. Plant Physiol., 33: 232-238.



Herbert Manoharan, T., Jayachandran, N., Karunagaran, D and Natarajan, K. R. (1981) Influence of Fluchloralin on the growth and metabolism of maize seedlings.  The Plant Biochem. J., (India), 8, 103-116.

Herbert Manoharan, T., Thirunavukkarasu, A., Karunagaran, D. and Natarajan, K. R. (1981) Effects of Fluchloralin on the metabolism of cowpea ( Vigna unguiculata L.) seedlings. Indian J. Exp. Biol., 19, 943-947


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