Signal Transduction Laboratory Bhupat and Jyoti Mehta School of Biosciences Indian Institute of Technology Madras, Chennai
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Publications Narayanasamy, S., Aradhyam, G.K. The differential response to Ca2+ from vertebrate and invertebrate Calumenin is governed by a single amino acid residue. Biochemistry. 57(5):722-731. Ashokan, A., Aradhyam, G. K. Measurement of intracellular Ca2+ mobilization to study GPCR signal transduction. Methods Cell Biol. 142:59-66 (2017). Ashokan, A., Aradhyam, G. K. Effective purification of recombinant peptide ligands for GPCR research. Methods Cell Biol. 142:111-118 (2017). Andhirka, S. K., Vignesh, R., Aradhyam, G. K. The nucleotide-free state of heterotrimeric G proteins α-subunit adopts a highly stable conformation. FEBS J. 284 (15):2464-2481 (2017). Kanuru, M., Aradhyam, G. K. Chaperone-like Activity of Calnuc Prevents Amyloid Aggregation. Biochemistry. 56(1):149-159 (2017). Ramanan, M., Pilli, V. S., Aradhyam G. K., Doble, M. Transcriptional regulation of microsomal prostaglandin E synthase 1 by the proto-oncogene, c-myc, in the pathogenesis of inflammation and cancer. Biochem. Biophys. Res. Commun. 482(4): 556-562 (2017). Kumar, P., Ashokan, A., Aradhyam, G. K. Apelin binding to human APJ receptor leads to biased signaling. Biochim. Biophys. Acta. Proteins and Proteomics. 1864(12): 1748-1756 (2016). Gupta, K., Pilli, V. S. S., Aradhyam, G. K. Left-right axis asymmetry determining human Cryptic gene is transcriptionally repressed by Snail. BMC Dev. Biol. 16(1): 1-10 (2016). Pilli, V. S. S., Anuradha, D., Manoj, N., Nagesh, N., Kumar, R. S., Aradhyam, G. K. Phenotypic Variations in the 22q11 Deletion Syndrome — Study in a South Indian Population. Indian J Pediatr. 3(7): 746-7 (2016). Pilli, V. S. S., Gupta, K., Kotha, B. P., Aradhyam, G. K. Snail-mediated Cripto-1 repression regulates the cell cycle and epithelial-mesenchymal transition-related gene expression. FEBS Lett. 589(11):1249-56 (2015). Kumar, P., Aradhyam, G. K. Easy and efficient protocol for purification of recombinant peptides. Protein Expression and Purification. 95:129-135 (2014). Kanuru, M., Raman, R., Aradhyam, G. K. Serine protease activity of calnuc: regulation by Zn2+ and G proteins. J. Biol. Chem. 288(3):1762-73 (2013) Singh, V., Nair, S. P., and Aradhyam G. K. Chemistry of conjugation to gold nanoparticles affects G-protein activity differently. J. Nanobiotechnology. 11:7 (2013) Tripathi, A., Singh, V., Aishwarya, K. G., Aradhyam, G.K. and Hotha, S. Engineered glucose to generate a spectroscopic probe for studying carbohydrate biology. Adv. Exp. Med. Biol. 749:313-27 (2012) Ghosh, A., Sonavane, U., Andhirka, S. K., Aradhyam G.K. and Joshi, R. Structural insights into human GPCR protein OA1: a computational perspective. J. Mol. Model. 18(5):2117-33 (2012) Aradhyam, G. K., Balivada, L. M., Kanuru, M., Vadivel, P., and Vidhya, B. S. Calnuc: Emerging roles in calcium signaling and human diseases. IUBMB Life. 62(6):436-46 (2010). Kanuru, M., Samuel, J. J., Balivada, L. M., and Aradhyam, G. K. Ion-binding properties of Calnuc, Ca2+ versus Mg2+--Calnuc adopts additional and unusual Ca2+-binding sites upon interaction with G-protein. FEBS J. 276(9):2529-46 (2009). Sahu, S. K., Aradhyam, G. K., and Gummadi, S. N. Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell. Biochim. Biophys. Acta. 1790(10):1274-81(2009). Sahu, S. K., Gopala Krishna, A., and Gummadi, S. N. Over-expression of recombinant human phospholipid scramblase 1 in E. coli and its purification from inclusion bodies. Biotechnol. Lett. 30(12):2131-7(2008). Kamesh, N., Aradhyam, G. K., and Manoj, N. The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis. BMC Evol. Biol. 8:129 (2008). Padma Sree, T. N., Krishna Kumar, S., Senthilkumar, S., Aradhyam, G. K. and Gumadi, S. N. In vitro Effect of Terminalia arjuna Bark Extract on Antioxidant Enzyme Catalase. Journal of Pharmacology and Toxicology 2 (8): 698-708 (2007). Sahu, S. K., Gummadi, S. N., Manoj, N., and Aradhyam, G. K. Phospholipid scramblases: an overview. Arch. of Biochem. and Biophy. 62(1):103-14. (2007). Krishna, A. G., Menon, S. T., Terry, T. J. & Sakmar, T. P. Evidence that Helix 8 of rhodopsin acts as a membrane-dependent conformational switch. Biochemistry. 41:8298-8309 (2002). Marin, E. P., Krishna, A. G. & Sakmar, T. P. Disruption of the α5 helix of transducin impairs rhodopsin-catalyzed nucleotide exchange. Biochemistry. 41: 6988-6994 (2002). Lehmann, N., Krishna, A. G. and Fahmy K Suramin affects coupling of rhodopsin to transducin. Biophys. J. 82: 793-802 (2002). Marin, E. P., Krishna, A. G. & Sakmar, T. P. Rapid activation of transducin by mutations distant from the nucleotide-binding site. J. Biol. Chem. 276: 27400-27405 (2001). Marin, E. P., Krishna, A. G., Archambault. V., Simuni. E., Fu. W-Y. & Sakmar, T. P. The function of interdomain interactions in controlling nucleotide exchange rates in transducin. J. Biol. Chem. 276: 23873-23880 (2001). Marin, E. P., Krishna, A. G., Zvyaga, T. A., Isele. J., Seibert, F. & Sakmar, T. P. The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction. J. Biol. Chem. 275: 1930-1936 (2000). Krishna, A. G.,* Kumar, D. V., Khan, B. M., Rawal, S. K. & Ganesh, K. N. Taxol-DNA Interaction: fluorescence and CD studies of the groove binding properties of taxol. Biochim. Biophys. Acta 1382: 104-112 (1998). * Corresponding Author. Krishna, A. G., Balasubramanian, D. & Ganesh, K. N. Sugar-DNA molecular recognition: Specific interaction of α (1,4) glucopyranose chains with DNA in the minor groove. Biochem. Biophys. Res. Comm. 202: 204-210 (1994). Sharma, Y., Krishna, A. G., Balasubramanian, D., Fairwell, T. & Krishna, G. Studies on the interaction of the dye, Stains-all, with individual calcium binding domains of Calmodulin. FEBS Letters 326: 59-64 (1993). Sharma, Y., Krishna, A. G., & Balasubramanian. D. Alteration of the dynamic quaternary structure and calcium-binding ability of β-crystallin by light. Photochem. Photobiol. 57: 739-743 (1993). Krishna, A. G., & Sharma, Y. Conformation of alginate and pectate chains monitored by the binding of the dye Stains-all. Ind. J. Biochem. Biophys. 28: 30-33 (1991). Sharma, Y., Rao, C. M., Rao, S.C., Krishna, A. G., Somasundaram, T. and Balasubramanian, D. Binding site conformation dictates the color of the dye Stains-all: A study of the binding of this dye to the eye lens proteins βγ-crystallins. J. Biol. Chem. 264: 20923-20927 (1989). Sharma, Y., Rao, C. M., Narasu, M.L., Rao, S. C., Somasundaram, T., Krishna, A. G., & Balasubramanian, D. Calcium ion binding to crystallins: the presence of the EF-hand motif in δcrystallin that aids in calcium ion binding. J. Biol. Chem. 264: 12794-12799 (1989).