Amal Kanti Bera

Amal Kanti Bera

Ph. D., University of Delhi

M. Sc., University of Calcutta


Office : Block:1 BT 403


Lab : BT 414 Lab website ➔

Research Areas

  • Structure function relationship of ion channels
  • Gap Junction Channel
  • GABAA Receptor Channel
  • Voltage Dependent Anion Channel of Mitochondria
  • Potassium Channel and Acid Sensing Ion Channel
  • Neuronal diseases associated with ion channels and receptors malfunctioning


Complete list of publications can be found on Scopus

  1. A selectivity filter mutation provides insights into gating regulation of a K+ channel Friesacher, T., Reddy, H.P., Bernsteiner, H., …Dascal, N., Stary-Weinzinger, A.Communications Biology, 2022, 5(1), 345

  2. HMGB3 inhibition by miR-142-3p/sh-RNA modulates autophagy and induces apoptosis via ROS accumulation and mitochondrial dysfunction and reduces the tumorigenic potential of human breast cancer cells Sharma, P., Yadav, P., Sundaram, S., …Bera, A.K., Karunagaran, D.Life Sciences, 2022, 304, 120727

  3. A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5) Shalomov, B., Handklo-Jamal, R., Reddy, H.P., …Bera, A.K., Dascal, N.Journal of Physiology, 2022, 600(6), pp. 1419�1437

  4. miR-142-3p simultaneously targets HMGA1, HMGA2, HMGB1, and HMGB3 and inhibits tumorigenic properties and in-vivo metastatic potential of human cervical cancer cells Sharma, P., Yadav, P., Jain, R.P., Bera, A.K., Karunagaran, D.Life Sciences, 2022, 291, 120268

  5. Yadav, P., Sharma, P., Sundaram, S., Venkatraman, G., Bera A.K., Karunagaran, D.(2021) SLC7A11/ xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells. Cancer Letters, DOI: 10.1016/j.canlet.2021.09.033

  6. Reddy, H.P.,Yakubovich, D., l Keren-Raifman, T., Tabak, G., Tsemakhovich, V.A., Pedersen, M.H., Shalomov, B., Colombo, S., Goldstein, D.B., Javitch, J.A., Bera, A.K., Dascal, N. (2021) Encephalopathy-causing mutations in G1(GNB1) alter regulation of neuronal GIRK channels. iScience 24, DOI:10.1016/j.isci.2021.103018

  7. Purohit, R., Bera, A.K. (2021) Pannexin 1 plays a pro-survival role by attenuating P2X7 receptor-mediated Ca2+ influx. Cell Calcium, 99,DOI:10.1016/j.ceca.2021.102458

  8. Purohit, R., Bera, A.K. (2021) Mutational effects of Pannexin 1 R217H depend on the carboxyl-terminus. Biochemical and Biophysical Research Communications, 548, pp. 143-147, DOI: 10.1016/j.bbrc.2021.02.060

  9. Mukhopadhyay, M., Bera, A.K. (2020) Modulation of acid-sensing ion channels by hydrogen sulfide. Biochemical and Biophysical Research Communications, 527 (1), pp. 71-75, DOI: 10.1016/j.bbrc.2020.04.092

  10. Colombo, S.,Petri,S.,Shalomov, B.,Reddy,H.P.,Tabak, G.,Dhindsa,R.S.,Gelfman,S., Teng,S.,Krizay, D.,Rafikian, E.E.,Bera, A.K.,Yang, M.,Boland, M.J.,Peng, Y.,Frankel, W.N., Dascal, N.,Goldstein, D.B. (2019) G protein-coupled potassium channels implicated in mouse andcellular models of GNB1 Encephalopathy. bioRxiv697235;DOI:

  11. Shalomov, B., Handklo-Jamal, R., Reddy, H.P., Theodor, N., Bera, A.K., Dascal, N. (2019) A revisedmechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4(KCNJ5).bioRxiv866202;DOI:

  12. Mohid, S.A., Ghorai, A., Ilyas, H., Mroue, K.H., Narayanan, G., Sarkar, A., Ray, S.K., Biswas, K., Bera, A.K., Malmsten, M., Midya, A., Bhunia, A. (2019) Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy. Colloids and Surfaces B: Biointerfaces, 176, pp. 360-370. DOI: 10.1016/j.colsurfb.2019.01.020

  13. Naushad, M., Durairajan, S.S.K., Bera, A.K., Senapati, S., Li, M. (2019) Natural Compounds with Anti-BACE1 Activity as Promising Therapeutic Drugs for Treating Alzheimer’s Disease. Planta Medica, 85 (17), pp. 1316-1325. DOI: 10.1055/a-1019-9819

  14. Ghosh, A., Khandelwal, N., Kumar, A., Bera, A.K. (2017) Leucine-rich repeat-containing 8B protein is associated with the endoplasmic reticulum calcium leak in HEK293 cells. Journal of Cell Science, 130 (22), pp. 3818-3828. DOI: 10.1242/jcs.203646

  15. Mukhopadhyay, M., Singh, A., Sachchidanand, S., Bera, A.K. (2017) Quercetin inhibits acid-sensing ion channels through a putative binding site in the central vestibular region. Neuroscience, 348, pp. 264-272. DOI: 10.1016/j.neuroscience.2017.02.025

  16. Sachidanandan, D., Reddy, H.P., Mani, A., Hyde, G.J., Bera, A.K. (2017) The Neuropeptide Orexin-A Inhibits the GABAA Receptor by PKC and Ca2+/CaMKII-Dependent Phosphorylation of Its 1 Subunit. Journal of Molecular Neuroscience, 61 (4), pp. 459-467, DOI: 10.1007/s12031-017-0886-0

  17. Tewari, D., Majumdar, D., Vallabhaneni, S., Bera, A.K. (2017) Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC). Scientific Reports, 7,DOI: 10.1038/srep45184

  18. Basak, D., Sridhar, S., Bera, A.K., Madhavan, N. (2017) A minimalistic tetrapeptide amphiphile scaffold for transmembrane pores with a preference for sodium. Bioorganic and Medicinal Chemistry Letters, 27 (13), pp. 2886-2889, DOI: 10.1016/j.bmcl.2017.04.081

  19. Uppal, S., Singh, A.K., Arya, R., Tewari, D., Jaiswal, N., Kapoor, A., Bera, A.K., Nag, A., Kundu, S. (2016) Phe28B10 Induces Channel-Forming Cytotoxic Amyloid Fibrillation in Human Neuroglobin, the Brain-Specific Hemoglobin. Biochemistry, 55 (49), pp. 6832-6847, DOI: 10.1021/acs.biochem.6b00617

  20. Tewari, D., Bera, A.K. (2016) Modulation of the voltage-dependent anion channel of mitochondria by elaidic acid. Biochemical and Biophysical Research Communications, 477 (3), pp. 490-494, DOI: 10.1016/j.bbrc.2016.06.067

  21. Rathnakumar, K., Savant, S., Giri, H., Ghosh, A., Fisslthaler, B., Fleming, I., Ram, U., Bera, A.K., Augustin, H.G., Dixit, M.(2016) Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability. Journal of Thrombosis and Haemostasis, 14 (8), pp. 1655-1667, DOI: 10.1111/jth.13376

  22. Kesavan, R., Chandel, S., Upadhyay, S., Bendre, R., Ganugula, R., Potunuru, U.R., Giri, H., Sahu, G., Kumar, P.U., Reddy, G.B., Joksic, G., Bera, A.K., Dixit, M. (2016) Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration. Nutrition, Metabolism and Cardiovascular Diseases, 26 (4), pp. 293-301. DOI: 10.1016/j.numecd.2015.12.016

  23. Tewari, D., Mukhopadhyay, M., Nekkanti, M.S., Vallabhaneni, S., Sahu, G., Jetti, S.K., Preethidan, D.S., Bera, A.K. (2016) Cytoprotective effect of Centella asiatica is mediated through the modulation of mitochondrial voltage-dependent anion channel (VDAC) and scavenging of free radicals. Journal of Functional Foods, 21, pp. 301-311. DOI: 10.1016/j.jff.2015.11.047

  24. Basak, D., Sridhar, S., Bera, A.K., Madhavan, N. (2016) Cation-halide transport through peptide pores containing aminopicolinic acid. Organic and Biomolecular Chemistry, 14 (20), pp. 4712-4717, DOI: 10.1039/c6ob00592f

  25. Sachidanandan, D., Bera, A.K. (2015) Inhibition of the GABAA Receptor by Sulfated Neurosteroids: A Mechanistic Comparison Study between Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate. Journal of Molecular Neuroscience, 56 (4), pp. 868-877, DOI: 10.1007/s12031-015-0527-4

  26. Poornima, V., Vallabhaneni, S., Mukhopadhyay, M., Bera, A.K. (2015) Nitric oxide inhibits the pannexin 1 channel through a cGMP-PKG dependent pathway. Nitric Oxide - Biology and Chemistry, 47, pp. 77-84, DOI: 10.1016/j.niox.2015.04.005

  27. Priya, M.K., Sahu, G., Soto-Pantoja, D.R., Goldy, N., Sundaresan, A.M., Jadhav, V., Barathkumar, T.R., Saran, U., Jaffar Ali, B.M., Roberts, D.D., Bera, A.K., Chatterjee, S. (2015) Tipping off endothelial tubes: nitric oxide drives tip cells. Angiogenesis, 18 (2), pp. 175-189, DOI: 10.1007/s10456-014-9455-0

  28. Singh, P.K., Ghosh, D., Tewari, D., Mohite, G.M., Carvalho, E., Jha, N.N., Jacob, R.S., Sahay, S., Banerjee, R., Bera, A.K., Maji, S.K. (2015) Cytotoxic helix-rich oligomer formation by melittin and pancreatic polypeptide. PLoS ONE, 10 (3)DOI: 10.1371/journal.pone.0120346

  29. Tewari, D., Ahmed, T., Chirasani, V.R., Singh, P.K., Maji, S.K., Senapati, S., Bera, A.K. (2015) Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin. Biochimica et Biophysica Acta - Biomembranes, 1848 (1), pp. 151-158, DOI: 10.1016/j.bbamem.2014.10.014

  30. Saha, T., Dasari, S., Tewari, D., Prathap, A., Sureshan, K.M., Bera, A.K., Mukherjee, A., Talukdar, P. (2014) Hopping-mediated anion transport through a mannitol-based rosette ion channel. Journal of the American Chemical Society, 136 (40), pp. 14128-14135, DOI: 10.1021/ja506278z

  31. Sahu, G., Sukumaran, S., Bera, A.K. (2014) Pannexins form gap junctions with electrophysiological and pharmacological properties distinct from connexins. Scientific Reports, 4, DOI: 10.1038/srep04955

  32. Allu, P.K.R., Chirasani, V.R., Ghosh, D., Mani, A., Bera, A.K., Maji, S.K., Senapati, S., Mullasari, A.S., Mahapatra, N.R. (2014) Naturally occurring variants of the dysglycemic peptide pancreastatin: Differential potencies for multiple cellular functions and structure-function correlation. Journal of Biological Chemistry, 289 (7), pp. 4455-4469,DOI: 10.1074/jbc.M113.520916

  33. Swain, S.M., Bera, A.K. (2013) Coupling of proton binding in extracellular domain to channel gating in acid-sensing ion channel. Journal of Molecular Neuroscience, 51 (1), pp. 199-207, DOI: 10.1007/s12031-013-9991-x

  34. Sahu, G., Bera, A.K. (2013) Contribution of Intracellular Calcium and pH in Ischemic Uncoupling of Cardiac Gap Junction Channels Formed of Connexins 43, 40,and 45: A Critical Function of C-Terminal Domain. PLoS ONE, 8 (3), DOI: 10.1371/journal.pone.0060506

  35. Sahu, B.S., Obbineni, J.M., Sahu, G., Allu, P.K.R., Subramanian, L., Sonawane, P.J., Singh, P.K., Sasi, B.K., Senapati, S., Maji, S.K., Bera, A.K., Gomathi, B.S., Mullasari, A.S., Mahapatra, N.R.(2012) Functional genetic variants of the catecholamine-release-inhibitory peptide catestatin in an Indian population: Allele-specific effects on metabolic traitsJournal of Biological Chemistry, 287 (52), pp. 43840-43852. DOI: 10.1074/jbc.M112.407916

  36. Swain, S.M., Parameswaran, S., Sahu, G., Verma, R.S., Bera, A.K. (2012) Proton-gated ion channels in mouse bone marrow stromal cells. Stem Cell Research, 9 (2), pp. 59-68. DOI: 10.1016/j.scr.2012.04.005

  37. Sahu, B.S., Mohan, J., Sahu, G., Singh, P.K., Sonawane, P.J., Sasi, B.K., Allu, P.K.R., Maji, S.K., Bera, A.K., Senapati, S., Mahapatra, N.R. (2012) Molecular interactions of the physiological anti-hypertensive peptide catestatin with the neuronal nicotinic acetylcholine receptor. Journal of Cell Science, 125 (11), p. 2787. DOI: 10.1242/jcs.114389

  38. Sahu, B.S., Obbineni, J.M., Sahu, G., Singh, P.K., Sonawane, P.J., Sasi, B.K., Allu, P.K.R., Maji, S.K., Bera, A.K., Senapati, S., Mahapatra, N.R. (2012) Molecular interactions of the physiological anti-hypertensive peptide catestatin with the neuronal nicotinic acetylcholine receptor. Journal of Cell Science, 125 (9), pp. 2323-2337. DOI: 10.1242/jcs.103176

  39. Poornima, V., Madhupriya, M., Kootar, S., Sujatha, G., Kumar, A., Bera, A.K. (2012) P2X 7 receptor-pannexin 1 hemichannel association: Effect of extracellular calcium on membrane permeabilization. Journal of Molecular Neuroscience, 46 (3), pp. 585-594. DOI: 10.1007/s12031-011-9646-8

  40. Chandrasekhar, A., Bera, A.K. (2012) Hemichannels: Permeants and their effect on development, physiology and death. Cell Biochemistry and Function, 30 (2), pp.8-100. DOI: 10.1002/cbf.2794

  41. Mohan, H., Maheswari, K.U., Bera, A.K., Suraishkumar, G.K. (2010) Reactive oxygen species mediated modifications in Bacillus subtilis lipid membrane to improve protein productivities. Process Biochemistry, 45 (4), pp. 467-474. DOI: 10.1016/j.procbio.2009.11.003

  42. Jetti, S.K., Swain, S.M., Majumder, S., Chatterjee, S., Poornima, V., Bera, A.K. (2010) Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death. Nitric Oxide - Biology and Chemistry, 22 (3), pp. 213-219. DOI: 10.1016/j.niox.2009.12.006

  43. Bera, A.K., Akabas, M.H. (2005) Spontaneous thermal motion of the GABAA receptor M2 channel-lining segments. Journal of Biological Chemistry, 280 (42), pp. 35506-35512. DOI: 10.1074/jbc.M504645200

  44. Bera, A.K., Chatav, M., Akabas, M.H. (2002) GABAA receptor M2-M3 loop secondary structure and changes in accessibility during channel gating. Journal of Biological Chemistry, 277 (45), pp. 43002-43010. DOI: 10.1074/jbc.M206321200

  45. Keren-Raifman, T., Bera, A.K., Zveig, D., Peleg, S., Witherow, D.Scott, Slepak, V.Z., Dascal, N. (2001) Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K+ channel and control regulation of RGS7 by G5. FEBS Letters, 492 (1-2), pp. 20-28. DOI: 10.1016/S0014-5793(01)02220-7

  46. Luo, X., Popov, S., Bera, A.K., Wilkie, T.M., Muallem, S. (2001) RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations. Molecular Cell, 7 (3), pp. 651-660. DOI: 10.1016/S1097-2765(01)00211-8

  47. Ghosh, S., Bera, A.K. (2001) The role of H + concentration on the capacitance of a membrane channel protein [1] Journal of Theoretical Biology, 208 (3), pp. 383-384. DOI: 10.1006/jtbi.2000.2200

  48. Bera, A.K., Ghosh, S. (2001) Dual mode of gating of voltage-dependent anion channel as revealed by phosphorylation. Journal of Structural Biology, 135 (1), pp. 67-72. DOI: 10.1006/jsbi.2001.4399

  49. Mullner, C., Vorobiov, D., Bera, A.K., Uezono, Y., Yakubovich, D., Frohnwieser-Steinecker, B., Dascal, N., Schreibmayer, W. (2000) Heterologous facilitation of G protein-activated K+ channels by - adrenergic stimulation via cAMP-dependent protein kinase. Journal of General Physiology, 115 (5), pp. 547-557. DOI: 10.1085/jgp.115.5.547

  50. Vorobiov, D., Bera, A.K., Keren-Raifman, T., Barzilai, R., Dascal, N. (2000) Coupling of the muscarinic m2 receptor to G protein-activated K+ channels via Ga(z) and a receptor-Ga(z) fusion protein. Fusion between the receptor and Ga(z) eliminates catalytic (collision) coupling. Journal of Biological Chemistry, 275 (6), pp. 4166-4170. DOI: 10.1074/jbc.275.6.4166

  51. Shin, D.M., Zhao, X.S., Luo, X., Bera, A.K., Muallem, S. (2000) Specificity of Ca2+ signaling in polarized cells. Advances in dental research, 14, pp. 12-15. DOI: 10.1177/08959374000140010101

  52. Vijayvergiya, V., Ghosh, P., Bera, A.K., Das, S. (1999) Bis[(benzo-15-crown-5)-15-yl methyl] Pimelate Forms Ion Channels in Planar Lipid Bilayer: A Novel Model Ion Channel. Physiological Chemistry and Physics and Medical NMR, 31 (2), pp. 93-102.

  53. Ghosh, S., Bera, A.K., Das, S. (1999) Evidence for nonlinear capacitance in biomembrane channel system. Journal of Theoretical Biology, 200 (3), pp. 299-305. DOI: 10.1006/jtbi.1999.0993

  54. Chandra, A., Ghosh, P., Mandaokar, A.D., Bera, A.K., Sharma, R.P., Das, S., Kumar, P.A. (1999) Amino acid substitution in a-helix 7 of Cry1Ac d-endotoxin of Bacillus thuringiensis leads to enhanced toxicity to HelicoverpaarmigeraHubner. FEBS Letters, 458 (2), pp. 175-179. DOI: 10.1016/S0014-5793(99)01157-6

  55. Bera, A.K., Ghosh, S., Das, S., Das, S. (1995) Mitochondrial VDAC Can Be Phosphorylated by Cyclic AMP-Dependent Protein Kinase. Biochemical and Biophysical Research Communications, 209 (1), pp. 213-217. DOI: 10.1006/bbrc.1995.1491

Book Chapter

  • Akabas MH, Horenstein J, Williams DB, Bali M, and Bera AK (2002) GABAA Receptors: Probing the Structural Basis of Function, Gating and Pharmacological Modulation by General Anesthetics. Molecular and Basic Mechanisms of Anesthesia.Ed. M. Barann and B.W. Urban. Pabst Science Publishers, Germany.