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Faculty

Amal Kanti Bera

Amal Kanti Bera

Ph. D., University of Delhi

M. Sc., University of Calcutta

Professor

amal@iitm.ac.in

Office : Block:1 BT 301

+91-44-2257-4121

Lab : BT 315 Lab website ➔

Research Areas

  • Structure function relationship of ion channels
  • Gap Junction Channel
  • GABAA Receptor Channel
  • Voltage Dependent Anion Channel of Mitochondria
  • Potassium Channel and Acid Sensing Ion Channel
  • Neuronal diseases associated with ion channels and receptors malfunctioning

Publications

  1. Yadav, P., Sharma, P., Sundaram, S., Venkatraman, G., Bera A.K., Karunagaran, D.(2021) SLC7A11/ xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells. Cancer Letters, DOI: 10.1016/j.canlet.2021.09.033

  2. Reddy, H.P.,Yakubovich, D., l Keren-Raifman, T., Tabak, G., Tsemakhovich, V.A., Pedersen, M.H., Shalomov, B., Colombo, S., Goldstein, D.B., Javitch, J.A., Bera, A.K., Dascal, N. (2021) Encephalopathy-causing mutations in G1(GNB1) alter regulation of neuronal GIRK channels. iScience 24, DOI:10.1016/j.isci.2021.103018

  3. Purohit, R., Bera, A.K. (2021) Pannexin 1 plays a pro-survival role by attenuating P2X7 receptor-mediated Ca2+ influx. Cell Calcium, 99,DOI:10.1016/j.ceca.2021.102458

  4. Purohit, R., Bera, A.K. (2021) Mutational effects of Pannexin 1 R217H depend on the carboxyl-terminus. Biochemical and Biophysical Research Communications, 548, pp. 143-147, DOI: 10.1016/j.bbrc.2021.02.060

  5. Mukhopadhyay, M., Bera, A.K. (2020) Modulation of acid-sensing ion channels by hydrogen sulfide. Biochemical and Biophysical Research Communications, 527 (1), pp. 71-75, DOI: 10.1016/j.bbrc.2020.04.092

  6. Colombo, S.,Petri,S.,Shalomov, B.,Reddy,H.P.,Tabak, G.,Dhindsa,R.S.,Gelfman,S., Teng,S.,Krizay, D.,Rafikian, E.E.,Bera, A.K.,Yang, M.,Boland, M.J.,Peng, Y.,Frankel, W.N., Dascal, N.,Goldstein, D.B. (2019) G protein-coupled potassium channels implicated in mouse andcellular models of GNB1 Encephalopathy. bioRxiv697235;DOI:https://doi.org/10.1101/697235.

  7. Shalomov, B., Handklo-Jamal, R., Reddy, H.P., Theodor, N., Bera, A.K., Dascal, N. (2019) A revisedmechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4(KCNJ5).bioRxiv866202;DOI: https://doi.org/10.1101/866202

  8. Mohid, S.A., Ghorai, A., Ilyas, H., Mroue, K.H., Narayanan, G., Sarkar, A., Ray, S.K., Biswas, K., Bera, A.K., Malmsten, M., Midya, A., Bhunia, A. (2019) Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy. Colloids and Surfaces B: Biointerfaces, 176, pp. 360-370. DOI: 10.1016/j.colsurfb.2019.01.020

  9. Naushad, M., Durairajan, S.S.K., Bera, A.K., Senapati, S., Li, M. (2019) Natural Compounds with Anti-BACE1 Activity as Promising Therapeutic Drugs for Treating Alzheimer’s Disease. Planta Medica, 85 (17), pp. 1316-1325. DOI: 10.1055/a-1019-9819

  10. Ghosh, A., Khandelwal, N., Kumar, A., Bera, A.K. (2017) Leucine-rich repeat-containing 8B protein is associated with the endoplasmic reticulum calcium leak in HEK293 cells. Journal of Cell Science, 130 (22), pp. 3818-3828. DOI: 10.1242/jcs.203646

  11. Mukhopadhyay, M., Singh, A., Sachchidanand, S., Bera, A.K. (2017) Quercetin inhibits acid-sensing ion channels through a putative binding site in the central vestibular region. Neuroscience, 348, pp. 264-272. DOI: 10.1016/j.neuroscience.2017.02.025

  12. Sachidanandan, D., Reddy, H.P., Mani, A., Hyde, G.J., Bera, A.K. (2017) The Neuropeptide Orexin-A Inhibits the GABAA Receptor by PKC and Ca2+/CaMKII-Dependent Phosphorylation of Its 1 Subunit. Journal of Molecular Neuroscience, 61 (4), pp. 459-467, DOI: 10.1007/s12031-017-0886-0

  13. Tewari, D., Majumdar, D., Vallabhaneni, S., Bera, A.K. (2017) Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC). Scientific Reports, 7,DOI: 10.1038/srep45184

  14. Basak, D., Sridhar, S., Bera, A.K., Madhavan, N. (2017) A minimalistic tetrapeptide amphiphile scaffold for transmembrane pores with a preference for sodium. Bioorganic and Medicinal Chemistry Letters, 27 (13), pp. 2886-2889, DOI: 10.1016/j.bmcl.2017.04.081

  15. Uppal, S., Singh, A.K., Arya, R., Tewari, D., Jaiswal, N., Kapoor, A., Bera, A.K., Nag, A., Kundu, S. (2016) Phe28B10 Induces Channel-Forming Cytotoxic Amyloid Fibrillation in Human Neuroglobin, the Brain-Specific Hemoglobin. Biochemistry, 55 (49), pp. 6832-6847, DOI: 10.1021/acs.biochem.6b00617

  16. Tewari, D., Bera, A.K. (2016) Modulation of the voltage-dependent anion channel of mitochondria by elaidic acid. Biochemical and Biophysical Research Communications, 477 (3), pp. 490-494, DOI: 10.1016/j.bbrc.2016.06.067

  17. Rathnakumar, K., Savant, S., Giri, H., Ghosh, A., Fisslthaler, B., Fleming, I., Ram, U., Bera, A.K., Augustin, H.G., Dixit, M.(2016) Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability. Journal of Thrombosis and Haemostasis, 14 (8), pp. 1655-1667, DOI: 10.1111/jth.13376

  18. Kesavan, R., Chandel, S., Upadhyay, S., Bendre, R., Ganugula, R., Potunuru, U.R., Giri, H., Sahu, G., Kumar, P.U., Reddy, G.B., Joksic, G., Bera, A.K., Dixit, M. (2016) Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration. Nutrition, Metabolism and Cardiovascular Diseases, 26 (4), pp. 293-301. DOI: 10.1016/j.numecd.2015.12.016

  19. Tewari, D., Mukhopadhyay, M., Nekkanti, M.S., Vallabhaneni, S., Sahu, G., Jetti, S.K., Preethidan, D.S., Bera, A.K. (2016) Cytoprotective effect of Centella asiatica is mediated through the modulation of mitochondrial voltage-dependent anion channel (VDAC) and scavenging of free radicals. Journal of Functional Foods, 21, pp. 301-311. DOI: 10.1016/j.jff.2015.11.047

  20. Basak, D., Sridhar, S., Bera, A.K., Madhavan, N. (2016) Cation-halide transport through peptide pores containing aminopicolinic acid. Organic and Biomolecular Chemistry, 14 (20), pp. 4712-4717, DOI: 10.1039/c6ob00592f

  21. Sachidanandan, D., Bera, A.K. (2015) Inhibition of the GABAA Receptor by Sulfated Neurosteroids: A Mechanistic Comparison Study between Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate. Journal of Molecular Neuroscience, 56 (4), pp. 868-877, DOI: 10.1007/s12031-015-0527-4

  22. Poornima, V., Vallabhaneni, S., Mukhopadhyay, M., Bera, A.K. (2015) Nitric oxide inhibits the pannexin 1 channel through a cGMP-PKG dependent pathway. Nitric Oxide - Biology and Chemistry, 47, pp. 77-84, DOI: 10.1016/j.niox.2015.04.005

  23. Priya, M.K., Sahu, G., Soto-Pantoja, D.R., Goldy, N., Sundaresan, A.M., Jadhav, V., Barathkumar, T.R., Saran, U., Jaffar Ali, B.M., Roberts, D.D., Bera, A.K., Chatterjee, S. (2015) Tipping off endothelial tubes: nitric oxide drives tip cells. Angiogenesis, 18 (2), pp. 175-189, DOI: 10.1007/s10456-014-9455-0

  24. Singh, P.K., Ghosh, D., Tewari, D., Mohite, G.M., Carvalho, E., Jha, N.N., Jacob, R.S., Sahay, S., Banerjee, R., Bera, A.K., Maji, S.K. (2015) Cytotoxic helix-rich oligomer formation by melittin and pancreatic polypeptide. PLoS ONE, 10 (3)DOI: 10.1371/journal.pone.0120346

  25. Tewari, D., Ahmed, T., Chirasani, V.R., Singh, P.K., Maji, S.K., Senapati, S., Bera, A.K. (2015) Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin. Biochimica et Biophysica Acta - Biomembranes, 1848 (1), pp. 151-158, DOI: 10.1016/j.bbamem.2014.10.014

  26. Saha, T., Dasari, S., Tewari, D., Prathap, A., Sureshan, K.M., Bera, A.K., Mukherjee, A., Talukdar, P. (2014) Hopping-mediated anion transport through a mannitol-based rosette ion channel. Journal of the American Chemical Society, 136 (40), pp. 14128-14135, DOI: 10.1021/ja506278z

  27. Sahu, G., Sukumaran, S., Bera, A.K. (2014) Pannexins form gap junctions with electrophysiological and pharmacological properties distinct from connexins. Scientific Reports, 4, DOI: 10.1038/srep04955

  28. Allu, P.K.R., Chirasani, V.R., Ghosh, D., Mani, A., Bera, A.K., Maji, S.K., Senapati, S., Mullasari, A.S., Mahapatra, N.R. (2014) Naturally occurring variants of the dysglycemic peptide pancreastatin: Differential potencies for multiple cellular functions and structure-function correlation. Journal of Biological Chemistry, 289 (7), pp. 4455-4469,DOI: 10.1074/jbc.M113.520916

  29. Swain, S.M., Bera, A.K. (2013) Coupling of proton binding in extracellular domain to channel gating in acid-sensing ion channel. Journal of Molecular Neuroscience, 51 (1), pp. 199-207, DOI: 10.1007/s12031-013-9991-x

  30. Sahu, G., Bera, A.K. (2013) Contribution of Intracellular Calcium and pH in Ischemic Uncoupling of Cardiac Gap Junction Channels Formed of Connexins 43, 40,and 45: A Critical Function of C-Terminal Domain. PLoS ONE, 8 (3), DOI: 10.1371/journal.pone.0060506

  31. Sahu, B.S., Obbineni, J.M., Sahu, G., Allu, P.K.R., Subramanian, L., Sonawane, P.J., Singh, P.K., Sasi, B.K., Senapati, S., Maji, S.K., Bera, A.K., Gomathi, B.S., Mullasari, A.S., Mahapatra, N.R.(2012) Functional genetic variants of the catecholamine-release-inhibitory peptide catestatin in an Indian population: Allele-specific effects on metabolic traitsJournal of Biological Chemistry, 287 (52), pp. 43840-43852. DOI: 10.1074/jbc.M112.407916

  32. Swain, S.M., Parameswaran, S., Sahu, G., Verma, R.S., Bera, A.K. (2012) Proton-gated ion channels in mouse bone marrow stromal cells. Stem Cell Research, 9 (2), pp. 59-68. DOI: 10.1016/j.scr.2012.04.005

  33. Sahu, B.S., Mohan, J., Sahu, G., Singh, P.K., Sonawane, P.J., Sasi, B.K., Allu, P.K.R., Maji, S.K., Bera, A.K., Senapati, S., Mahapatra, N.R. (2012) Molecular interactions of the physiological anti-hypertensive peptide catestatin with the neuronal nicotinic acetylcholine receptor. Journal of Cell Science, 125 (11), p. 2787. DOI: 10.1242/jcs.114389

  34. Sahu, B.S., Obbineni, J.M., Sahu, G., Singh, P.K., Sonawane, P.J., Sasi, B.K., Allu, P.K.R., Maji, S.K., Bera, A.K., Senapati, S., Mahapatra, N.R. (2012) Molecular interactions of the physiological anti-hypertensive peptide catestatin with the neuronal nicotinic acetylcholine receptor. Journal of Cell Science, 125 (9), pp. 2323-2337. DOI: 10.1242/jcs.103176

  35. Poornima, V., Madhupriya, M., Kootar, S., Sujatha, G., Kumar, A., Bera, A.K. (2012) P2X 7 receptor-pannexin 1 hemichannel association: Effect of extracellular calcium on membrane permeabilization. Journal of Molecular Neuroscience, 46 (3), pp. 585-594. DOI: 10.1007/s12031-011-9646-8

  36. Chandrasekhar, A., Bera, A.K. (2012) Hemichannels: Permeants and their effect on development, physiology and death. Cell Biochemistry and Function, 30 (2), pp.8-100. DOI: 10.1002/cbf.2794

  37. Mohan, H., Maheswari, K.U., Bera, A.K., Suraishkumar, G.K. (2010) Reactive oxygen species mediated modifications in Bacillus subtilis lipid membrane to improve protein productivities. Process Biochemistry, 45 (4), pp. 467-474. DOI: 10.1016/j.procbio.2009.11.003

  38. Jetti, S.K., Swain, S.M., Majumder, S., Chatterjee, S., Poornima, V., Bera, A.K. (2010) Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death. Nitric Oxide - Biology and Chemistry, 22 (3), pp. 213-219. DOI: 10.1016/j.niox.2009.12.006

  39. Bera, A.K., Akabas, M.H. (2005) Spontaneous thermal motion of the GABAA receptor M2 channel-lining segments. Journal of Biological Chemistry, 280 (42), pp. 35506-35512. DOI: 10.1074/jbc.M504645200

  40. Bera, A.K., Chatav, M., Akabas, M.H. (2002) GABAA receptor M2-M3 loop secondary structure and changes in accessibility during channel gating. Journal of Biological Chemistry, 277 (45), pp. 43002-43010. DOI: 10.1074/jbc.M206321200

  41. Keren-Raifman, T., Bera, A.K., Zveig, D., Peleg, S., Witherow, D.Scott, Slepak, V.Z., Dascal, N. (2001) Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K+ channel and control regulation of RGS7 by G5. FEBS Letters, 492 (1-2), pp. 20-28. DOI: 10.1016/S0014-5793(01)02220-7

  42. Luo, X., Popov, S., Bera, A.K., Wilkie, T.M., Muallem, S. (2001) RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations. Molecular Cell, 7 (3), pp. 651-660. DOI: 10.1016/S1097-2765(01)00211-8

  43. Ghosh, S., Bera, A.K. (2001) The role of H + concentration on the capacitance of a membrane channel protein [1] Journal of Theoretical Biology, 208 (3), pp. 383-384. DOI: 10.1006/jtbi.2000.2200

  44. Bera, A.K., Ghosh, S. (2001) Dual mode of gating of voltage-dependent anion channel as revealed by phosphorylation. Journal of Structural Biology, 135 (1), pp. 67-72. DOI: 10.1006/jsbi.2001.4399

  45. Mullner, C., Vorobiov, D., Bera, A.K., Uezono, Y., Yakubovich, D., Frohnwieser-Steinecker, B., Dascal, N., Schreibmayer, W. (2000) Heterologous facilitation of G protein-activated K+ channels by - adrenergic stimulation via cAMP-dependent protein kinase. Journal of General Physiology, 115 (5), pp. 547-557. DOI: 10.1085/jgp.115.5.547

  46. Vorobiov, D., Bera, A.K., Keren-Raifman, T., Barzilai, R., Dascal, N. (2000) Coupling of the muscarinic m2 receptor to G protein-activated K+ channels via Ga(z) and a receptor-Ga(z) fusion protein. Fusion between the receptor and Ga(z) eliminates catalytic (collision) coupling. Journal of Biological Chemistry, 275 (6), pp. 4166-4170. DOI: 10.1074/jbc.275.6.4166

  47. Shin, D.M., Zhao, X.S., Luo, X., Bera, A.K., Muallem, S. (2000) Specificity of Ca2+ signaling in polarized cells. Advances in dental research, 14, pp. 12-15. DOI: 10.1177/08959374000140010101

  48. Vijayvergiya, V., Ghosh, P., Bera, A.K., Das, S. (1999) Bis[(benzo-15-crown-5)-15-yl methyl] Pimelate Forms Ion Channels in Planar Lipid Bilayer: A Novel Model Ion Channel. Physiological Chemistry and Physics and Medical NMR, 31 (2), pp. 93-102.

  49. Ghosh, S., Bera, A.K., Das, S. (1999) Evidence for nonlinear capacitance in biomembrane channel system. Journal of Theoretical Biology, 200 (3), pp. 299-305. DOI: 10.1006/jtbi.1999.0993

  50. Chandra, A., Ghosh, P., Mandaokar, A.D., Bera, A.K., Sharma, R.P., Das, S., Kumar, P.A. (1999) Amino acid substitution in a-helix 7 of Cry1Ac d-endotoxin of Bacillus thuringiensis leads to enhanced toxicity to HelicoverpaarmigeraHubner. FEBS Letters, 458 (2), pp. 175-179. DOI: 10.1016/S0014-5793(99)01157-6

  51. Bera, A.K., Ghosh, S., Das, S., Das, S. (1995) Mitochondrial VDAC Can Be Phosphorylated by Cyclic AMP-Dependent Protein Kinase. Biochemical and Biophysical Research Communications, 209 (1), pp. 213-217. DOI: 10.1006/bbrc.1995.1491

Book Chapter

  • Akabas MH, Horenstein J, Williams DB, Bali M, and Bera AK (2002) GABAA Receptors: Probing the Structural Basis of Function, Gating and Pharmacological Modulation by General Anesthetics. Molecular and Basic Mechanisms of Anesthesia.Ed. M. Barann and B.W. Urban. Pabst Science Publishers, Germany.