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Faculty

N Manoj

N Manoj

Ph.D, Indian Institute of Science,

M.Sc, University of Mysore

Professor

nmanoj@iitm.ac.in

Office : Block:1 BT 304

+91-44-2257-4113

Research Interests

  • Structural biochemistry of hydrolases

  • Protein structure and function

  • Computational molecular evolution

  • Bioinformatics

Publications

  • Ravisankar V, Singh TP, Manoj N. Molecular evolution of the EGF-CFC protein family. Gene 2011 482(1-2):43-50.

  • Prasobh R, Manoj N. The Repertoire of Heterotrimeric G Proteins and RGS Proteins in Ciona intestinalis. PLoS ONE 2009 4(10): e7349.

_ Kiranmayee B, Gummadi SN, Manoj N. Biochemical characterization of Alr1529, a novel SGNH hydrolase variant from Anabaena sp. PCC 7120. Biophys Biochem Acta - Proteins & Proteomics 2009 Feb;1794(2):324-34.

  • Kamesh N, Aradhyam GK, Manoj N. The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis. BMC Evol Biol. 2008 May 1;8:129.

  • Sahu SK, Gummadi SN, Manoj N, Aradhyam GK. Phospholipid scramblases: an overview. Arch Biochem Biophys. 2007 Jun 1;462(1):103-14. Review.

  • Manoj N, Ealick SE. Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase. Acta Cryst D 2003 Oct;59:1762-6

  • Manoj N, Strauss E, Begley TP, Ealick SE. Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Structure. 2003 Aug;11(8):927-36.

  • Manoj N, Suguna K. Signature of quaternary structure in the sequences of legume lectins. Protein Eng. 2001 Oct;14(10):735-45.

  • Manoj N, Jeyaprakash AA, Pratap JV, Komath SS, Kenoth R, Swamy MJ, Vijayan M. Crystallization and preliminary X-ray studies of snake gourd lectin: homology with type II ribosome-inactivating proteins. Acta Cryst D 2001 Jun;57:912-4

  • Saraswathi NT, Manoj N, Vijayan M. X-ray studies on crystalline complexes involving amino acids and peptides. XXXVII. Novel aggregation patterns and effect of chirality in the complexes of DL- and L-lysine with glutaric acid. Acta Cryst B. 2001 Jun;57:366-71.

  • Manoj N, Srinivas VR, Surolia A, Vijayan M, Suguna K. Carbohydrate specificity and salt-bridge mediated conformational change in acidic winged bean agglutinin. J Mol Biol. 2000 Oct 6;302(5):1129-37.

  • Manoj N, Vijayan M. X-ray studies on crystalline complexes involving amino acids and peptides. XXXVI. Crystal structures of hydrated glycyl-L-histidine and L- histidyl-L-alanine complexes with oxalic acid. J Pept Res. 2000 Oct;56(4):210-7.

  • Manoj N, Srinivas VR, Satish B, Singha NC, Suguna K. Crystallization and preliminary crystallographic analysis of winged bean acidic lectin. Acta Cryst D 1999 Feb;55:564-5.

  • Manoj N, Srinivas VR, Suguna K. Structure of basic winged-bean lectin and a comparison with its saccharide-bound form. Acta Cryst D 1999 Apr;55:794-800.

Chapter in book

  • S.N. Gummadi, N. Manoj, D. Sunil kumar (2006) Structural and biochemical properties of pectinases. In: -Industrial Enzymes: Structure, Function and Applications (eds. J. Polaina and A.P. MacCabe, Springer, pp 99-115