Santhosh Sethuramanujam

Santhosh Sethuramanujam

Ph.D., State University of New York at Buffalo, USA.

Assistant Professor

Office : Block 1,BT:503


Research Interests

  • Visual information encoded by neuronal circuits
  • Neuronal communication
  • Information processing in dendrites
  • Role of neuropeptides in facilitating neuronal function
  • Mechanisms underlying neuronal degeneration
  • Development of strategies for vision restoration


  • Sethuramanujam S*, Matsumoto A*, deRosenroll G, Murphy-Baum B, McIntosh JM, Jing M, Li Y, Berson D, Yonehara K and Awatramani GB (2021). Rapid multi-directed cholinergic transmission in the central nervous system. Nature Communications 12, 1374.

  • Charish J, Shabanzadeh AP, Chen D, Mehlen P, Sethuramanujam S, Harada H, Bonilha VL, Awatramani GB, Bremner R and Monnier PP (2020). Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration. The Journal of clinical investigation 130: 2054-2068.

  • Jain V*, Murphy-Baum BL*, deRosenroll G, Sethuramanujam S, Delsey M, Delaney K and Awatramani GB (2020). The functional organization of excitation and inhibition in the dendrites of mouse direction-selective ganglion cells. Elife 9.

  • Hanson L*, Sethuramanujam S*, deRosenroll G, Jain V and Awatramani GB (2019). Retinal direction selectivity in the absence of asymmetric starburst amacrine cell responses. Elife 8.

  • Sethuramanujam S, Awatramani GB and Slaughter MM (2018). Cholinergic excitation complements glutamate in coding visual information in retinal ganglion cells. J Physiol. 596(16): 3709-3724.

  • Sethuramanujam S,Yao X, deRosenroll G, Briggman KL, Field GD and Awatramani GB (2017). Silent NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit. Neuron. Dec 6; 96(5): 1099-1111.

  • Sethuramanujam S, McLaughlin AJ, deRosenroll G, Hoggarth A, Schwab D and Awatramani GB(2016). A Central Role for Mixed Acetylcholine/GABA Transmission in Direction Coding in the Retina. Neuron. June 15; 90(6): 1243-1256.

  • Sethuramanujam S and Slaughter MM (2015). Properties of a Glutamatergic Synapse ControllingInformation Output from Retinal Bipolar Cells. PLoS One 10(6): e0129133.doi:10.1371/journal.pone.0129133.

  • Hoggarth A, McLaughlin AJ, Ronellenfitch K, Trenholm S, Vasandani R, Sethuramanujam S, Schwab D, Briggman KL, Awatramani GB (2015). Specific wiring of distinct amacrine cells in thedirectionally selective retinal circuit permits independent coding of direction and size. Neuron. 2015 Apr 8;86(1):276-91.

  • Wu F, Kaczynski TJ, Sethuramanujam S, Li R, Jain V, Slaughter M, Mu X (2015). Twotranscription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1559-68.

  • Sethuramanujam S and Slaughter MM (2014). Disinhibitory Recruitment of NMDA receptorpathways in retina. J. Neurophysiol. 112:193-203, 2014.B. Biton, Sethuramanujam S, Kelly E. Picchione, A. Bhattacharjee, N. Khessibi, F. Chesney, C. Lanneau, O. Curet, and P. Avenet. (2012). The Antipsychotic Drug Loxapine Is an Opener of the Sodium-Activated Potassium Channel Slack (Slo2.2). JPET 340:706 715, 2012

  • indicates equal contribution

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