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Faculty

V Kesavan

V Kesavan

Ph.D, Indian Institute of Science,

M.Sc, Madurai Kamaraj University

Professor

vkesavan@iitm.ac.in

Office : Block:1 BT 405

+91-44-2257-4124

Research Interests

  • Rational drug design, Synthesis & Evaluation
  • Targeted Protein Degradation
  • Medicinal Chemistry and Drug Design

Publications

Complete list of publications can be found on Scopus
  • Priyanka, V. P., Harikrishna, A. S., Kesavan, V., & Gardas, R. L. (2024). Synergistic interaction and antibacterial properties of surface-active mono-and di-cationic ionic liquids with ciprofloxacin. Journal of Molecular Liquids, 399, 124359. DOI: doi.org/10.1016/j.molliq.2024.124359
  • Sood, A., & Kesavan, V. (2023). Synthesis and antibacterial activity of 2-benzylidene-3-oxobutanamide derivatives against resistant pathogens. RSC Medicinal Chemistry, 14(9), 1817-1826. DOI: dx.doi.org/10.1039/D3MD00051F
  • Kumar, A. S., Jagadeeshan, S., Pitani, R. S., Ramshankar, V., Venkitasamy, K., Venkatraman, G., & Rayala, S. K. (2023). Snail-modulated microRNA 493 forms a negative feedback loop with the insulin-like growth factor 1 receptor pathway and blocks tumorigenesis. Molecular and Cellular Biology, 37(6), e00510-16. DOI: doi.org/10.1128/MCB.00510-16
  • Harikrishna, A. S., & Venkitasamy, K. (2023). Identification of novel human nicotinamide N-methyltransferase inhibitors: a structure-based pharmacophore modeling and molecular dynamics approach. Journal of Biomolecular Structure and Dynamics, 41(24), 14638-14650. DOI: doi.org/10.1080/07391102.2023.2183714
  • Lokesh, K., Kumarswamyreddy, N., & Kesavan, V. (2022). Diastereoselective Construction of Tetrahydro-Dispiro [indolinone-3, 2′-pyran-5′, 4 ″-pyrazolone] Scaffolds via an Oxa-Michael Cascade [4+ 2] Annulation Reaction. The Journal of Organic Chemistry, 88(22), 15540-15550. DOI: doi.org/10.1021/acs.joc.2c01370
  • Muthusamy, S., Kumarswamyreddy, N., & Kesavan, V. (2022). Enantioselective Synthesis of 3‐Amino‐3’‐carbazole Oxindole Derivatives via Friedel‐Crafts Aminoalkylation Reaction. ChemistrySelect, 7(7), e202200131. DOI: dx.doi.org/10.1002/slct.202200131
  • Kumarswamyreddy, N., Jayakumar, S., & Kesavan, V. (2021). Palladium-catalyzed asymmetric allylic alkylation of 3-amino-2-oxindoles: Synthesis of 3-allyl-3-amino-2-oxindoles. Tetrahedron Letters, 82, 153385. DOI: doi.org/10.1016/j.tetlet.2021.153385
  • Pratap Reddy Gajulapalli, V., Kumarswamyreddy, N., Lokesh, K., & Kesavan, V. (2021). Enantioselective Synthesis of 3‐Acetyl Coumarin Substituted 3‐Hydroxy Oxindoles and Pyranocoumarin Fused Spirooxindoles. ChemistrySelect, 6(31), 7855-7859. DOI: doi.org/10.1002/slct.202102495
  • Rai, R. K., Kanniyappan, H., Muthuvijayan, V., Venkitasamy, K., & Jayakrishnan, A. (2021). Durable polymeric N-halamine functionalized stainless steel surface for improved antibacterial and anti-biofilm activity. Materials Advances, 2(3), 1090-1098. DOI: dx.doi.org/10.1039/D0MA00828A
  • Sivamuthuraman, K., & Kesavan, V. (2019). Catalytic enantioselective Michael addition of 2-substituted benzofuran-3-ones to 2-enoyl pyridines. Organic & Biomolecular Chemistry, 17(30), 7166-7171. DOI: dx.doi.org/10.1039/C9OB01069F
  • Muthusamy, S., & Kesavan, V. (2019). Asymmetric Cycloaddition Reactions of Oxindole α‐Keto Esters via Cascade Dienamine‐Enamine and Trienamine Strategies. European Journal of Organic Chemistry, 2019(25), 4046-4055. DOI: dx.doi.org/10.1002/ejoc.201900567
  • Kumarswamyreddy, N., Lokesh, K., & Kesavan, V. (2018). Efficient synthesis of highly functionalized indole and phenol containing 3, 3′-disubstituted oxindoles and chromene fused spirooxindoles. Tetrahedron Letters, 59(49), 4344-4348. DOI: dx.doi.org/10.1016/j.tetlet.2018.10.064
  • Sivamuthuraman, K., & Kesavan, V. (2018). Stereodivergent synthesis of 3-aminooxindole derivatives containing vicinal tetrasubstituted stereocenters via the Mannich reaction. The Journal of Organic Chemistry, 83(16), 8936-8952. DOI: dx.doi.org/10.1021/acs.joc.8b01020
  • Ravichandran, V., Kesavan, V., Cojean, S., Loiseau, P. M., & Jayakrishnan, A. (2018). Polysorbate surfactants as drug carriers: Tween 20-Amphotericin B conjugates as anti-fungal and anti-leishmanial agents. Current Drug Delivery, 15(7), 1028-1037. DOI: dx.doi.org/10.2174/1567201815666180503122829
  • Ravichandran, V., Mekarnia, N., Pomel, S., Cojean, S., Ferrié, L., Figadère, B., Kesavan, V.... & Jayakrishnan, A. (2018). New Water-Soluble Polymeric Prodrugs of 2-n-propylquinoline: Synthesis and Evaluation of In Vitro and In Vivo Activities Against Leishmania donovani. Regenerative Engineering and Translational Medicine, 4, 11-20. DOI: dx.doi.org/10.1007/s40883-018-0045-3
  • Lokesh, K., & Kesavan, V. (2017). Efficient Synthesis of Highly Functionalized Spirocarbocyclic Oxindoles through Hauser Annulation. European Journal of Organic Chemistry, 2017(37), 5689-5695. DOI: dx.doi.org/10.1002/ejoc.201701023

Patents

  • Manoharan, Muthiah; Kesavan, Venkitasamy; Rajeev, Kallanthottathil G. Preparation of cholesterol-chemically modified DNA duolexes and their use for inhibiting gene expression. PCT Int. Appl. (2006), 265 pp. CODEN: PIXXD2 WO 2006020768 A2 20060223 AN 2006:164429
  • Dhanoa, Dale S.; Becker, Oren; Noiman, Silvia; Alla, Sekar Reddy; Cheruku, Srinivasa Rao; Mele-ndez, Rosa E.; Sharadendu, Anurag; Chen, Dongli; Marantz, Yael; Shacham, Sharon; Heifetz, Alexander; Inbal, Boaz; Kesavan, Venkitasamy; Bar-haim, Shay. Preparation of piperidinylamino-thieno[2,3-d]pyrimidine compounds as 5-HT2B modulators. U.S. Pat. Appl. Publ. (2005), 73 pp., Cont.-in-part of U.S. Ser. No. 947,995. CODEN: USXXCO US 2005222176 A1 20051006 CAN 143:367320 AN 2005:1078251
  • Dhanoa, Dale S.; Becker, Oren; Noiman, Silvia; Reddy, Sekar A.; Cheruku, Srinivasa Rao; Mele-ndez, Rosa E.; Sharadendu, Anurag; Chen, Dongli; Marantz, Yael; Shacham, Sharon; Heifetz, Alexander; Inbal, Boaz; Kesavan, Venkitasamy; Bar-haim, Shay. Preparation of piperidinylamino-thieno[2,3-d]pyrimidine compounds as 5-HT2B modulators. U.S. Pat. Appl. Publ. (2005), 73 pp., Cont.-in-part of U.S. Ser. No. 815,417. CODEN: USXXCO US 2005222175 A1 20051006 CAN 143:367319 AN 2005:1078250
  • Manoharan, Muthiah; Kesavan, Venkitasamy; Rajeev, Kallanthottathil G. SiRNA-s containing ribose substitutes to which lipophilic moieties may be attached. U.S. Pat. Appl. Publ. (2005), 273 pp., Cont.-in-part of Appl. No. PCT/US04/011829. CODEN: USXXCO US 2005107325 A1 20050519 CAN 142:477067 AN 2005:431390
  • Dhanoa, D. S.; Becker, O.; Noiman, S.; Cheruku, S.R.; Marantz, Y.; Shachem, S.; Heifetz, A.; Inbal, B.; Kesavan, V.; Bar-haim, S.; Reddy, S.A.; Melendez, R. E.; Sharadendu, A.; Chen, D. New piperidinylamino-thieno[2,3-d]pyrimidine compounds. PCT Int. Appl. (2004), 106 pp. WO 2004089312
  • Becker, O.; Dhanoa, D. S.; Noiman, S.; Sharadendu, A.; Kesavan, V.; Mohanty, P.; Marantz, Y.; Kalid, O.; Chen, D.; Sharon, S.; Nudelman, R. Triazole neurokinin antagonists. PCT Int. Appl. (2004), 67 pp. WO 2004030629.
  • Becker, O.; Chen, D.; Cheruku, S. R.; Dhanoa, D. S.; Heifetz, A.; Kalid, O.; Kesavan, V.; Marantz, Y.; Mohanty, P.; Noiman, S.; Nudelman, R.; Shachem, S.; Sharadendu, A. Preparation of substituted aminopyrimidines as neurokinin antagonists effective for treating CNS disorders. PCT Int. Appl. (2004), 70 pp. WO 2004014850

Honours and Awards

  • Recipient of The Guha Research Medal (best thesis of the Department of Organic Chemistry, IISc, Bangalore, India, for the year 1999-2000).