Department of Biotechnology | Indian Institute Of Technology Madras , Chennai
team

A Gopala Krishna

Professor

Ph.D., University of Pune

M.Sc., Annamalai University

Block 1, BT 302

044 2257 4112

agk[at]iitm[.]ac[.]in

Lab: Block I, BT 308

Lab: 044 2257 5100

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  • G-Protein Coupled Receptor (GPCR) mediated signal transduction pathways
  • Mechanism of G protein activation
  • Membrane protein biochemistry
  • Protein structure-function
  • Protein folding

  1. Kanumuri, R., Chelluboyina, A. K., Biswal, J., Vignesh, R., Pandian, J., Venu, A., Vaishnavi, B., Leena, D. J., Jeyaraman, J., Ganesan, K., Aradhyam, G. K., Venkatraman, G., & Rayala, S. K (2021). "Small peptide inhibitor from the sequence of RUNX3 disrupts PAK1-RUNX3 interaction and abrogates its phosphorylation-dependent oncogenic function", Oncogene, 40(34), pp. 5327–5341, DOI: 10.1038/s41388-021-01927-x.
  2. Aradhyam, G. K., & Jagannathan, N. R (2023). "Gobind: an inspiring enigma", Biophysical reviews, 15(1), pp. 71–73, DOI: 10.1007/s12551-023-01045-w.
  3. Murali, S., & Aradhyam, G. K (2023). "Correction to: Structure–function relationship and physiological role of apelin and its G protein coupled receptor (Biophysical Reviews, (2023), 15, 1, (127-143), 10.1007/s12551-023-01044-x)", Biophysical reviews, 15(2), pp. 293–294, DOI: 10.1007/s12551-023-01050-z.
  4. Yadav, M. P., Narayanasamy, S., & Aradhyam, G. K (2024). "Structural Plasticity Allows Calumenin-1 to Moonlight as a Ca2+-Independent Chaperone: Pb2+ Enables Probing Alternate Inhibitory Conformation", Biochemistry, 63(1), pp. 69–81, DOI: 10.1021/acs.biochem.3c00326.
  5. Vignesh, R., & Aradhyam, G. K. (2023). "Calnuc-derived nesfatin-1-like peptide is an activator of tumor cell proliferation and migration", FEBS letters, 597(18), pp. 2288–2300, DOI: 10.1002/1873-3468.14712.