Department of Biotechnology | Indian Institute Of Technology Madras , Chennai
team

Nathiya Muthalagu

Assistant Professor

Ph.D., University of Glasgow, Scotland, UK.

M.Sc., University of Madras, Chennai, TN, India.

Block 2, BT 122

044 2257 4136

nathiya[at]iitm[.]ac[.]in

Lab: Block 2, BT 108

044 2257 8994

Lab Website
Scopus
Google Scholar

  • Pancreatic cancer evolution, Cellular plasticity, Metastasis, chemoresistance, Mouse models
  • Molecular Oncology Lab
  • The overarching goal of our lab is to understand, at the molecular and cellular level how oncogenes control neuroendocrine plasticity, how this contributes to metastasis and how w

  1. Farrell, A. S., Joly, M. M., Allen-Petersen, B. L., Worth, P. J., Lanciault, C., Sauer, D., Link, J., Pelz, C., Heiser, L. M., Morton, J. P.,Muthalagu, N., Hoffman, M. T., Manning, S. L., Pratt, E. D., Kendsersky, N. D., Egbukichi, N., Amery, T. S., Thoma, M. C., Jenny, Z. P., Rhim, A. D., Murphy, D. J., Sansom, O. J., Crawford, H. C., Sheppard, B. C. & Sears, R. C. (2017). "MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance", Nat Commun, 8, pp. 1728.
  2. Port, J., Muthalagu, N., Raja, M., Ceteci, F., Monteverde, T., Kruspig, B., Hedley, A., Kalna, G., Lilla, S., Neilson, L., Brucoli, M., Gyuraszova, K., Tait-Mulder, J., Mezna, M., Svambaryte, S., Bryson, A., Sumpton, D., McVie, A., Nixon, C., Drysdale, M., Esumi, H., Murray, G. I., Sansom, O. J., Zanivan, S. R. & Murphy, D. J (2018). "Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress", Cancer Discov, 8, pp. 632-647.
  3. Muthalagu, N. & Murphy, D. J.. "Is oxidative stress MYC-s Achilles heel?", Cell Death Differ, 25, pp. 1189-1190.
  4. Bott, A. J., Shen, J., Tonelli, C., Zhan, L., Sivaram, N., Jiang, Y. P., Yu, X., Bhatt, V., Chiles, E., Zhong, H., Maimouni, S., Dai, W., Velasquez, S., Pan, J. A., Muthalagu, N., Morton, J., Anthony, T. G., Feng, H., Lamers, W. H., Murphy, D. J., Guo, J. Y., Jin, J., Crawford, H. C., Zhang, L., White, E., Lin, R. Z., Su, X., Tuveson, D. A. &Zong, W. X. (2019). "Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism", Cell Rep, 29, pp. 1287-1298.
  5. Repression of Type I Interferon pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B cells in Pancreatic Ductal Adenocarcinoma (2020). "Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu R, Whyte, D., Hedley, A., Laing, S., Upstill-Goddard, R., Shaw, R., Neidler, S., Gyuraszova, K., Nixon, C., Clark, W., Biankin, A., Carlin, L., Coffelt, S., Sansom, O. J., Morton, J. & Murphy, D. J.", Cancer Discov, 10, pp. 872-87.