Department of Biotechnology | Indian Institute Of Technology Madras , Chennai
faculty member

Nathiya Muthalagu

Assistant Professor

Education Icon

Ph.D.,  University of Glasgow, Scotland, UK.

Education Icon

M.Sc.,  University of Madras, Chennai, TN, India.

Office Icon

Block 2, BT 122

Phone Icon

044 2257 4136

Mail Icon

nathiya[at]iitm[.]ac[.]in

Lab Icon

Lab: Block 2, BT 108

Phone Icon

044 2257 8994

Website Icon Lab Website
Scopus Icon Scopus
Scholar Icon Google Scholar

  • To understand, at the molecular and cellular level how oncogenes control neuroendocrine plasticity, how this contributes to metastasis and chemoresistance.
  • To characterize the mechanism of pancreatic neuroendocrine tumour progression using mouse models of pancreatic cancer.

  1. Farrell, A. S., Joly, M. M., Allen-Petersen, B. L., Worth, P. J., Lanciault, C., Sauer, D., Link, J., Pelz, C., Heiser, L. M., Morton, J. P.,Muthalagu, N., Hoffman, M. T., Manning, S. L., Pratt, E. D., Kendsersky, N. D., Egbukichi, N., Amery, T. S., Thoma, M. C., Jenny, Z. P., Rhim, A. D., Murphy, D. J., Sansom, O. J., Crawford, H. C., Sheppard, B. C. & Sears, R. C. (2017). "MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance", Nat Commun, 8, pp. 1728.
  2. Port, J., Muthalagu, N., Raja, M., Ceteci, F., Monteverde, T., Kruspig, B., Hedley, A., Kalna, G., Lilla, S., Neilson, L., Brucoli, M., Gyuraszova, K., Tait-Mulder, J., Mezna, M., Svambaryte, S., Bryson, A., Sumpton, D., McVie, A., Nixon, C., Drysdale, M., Esumi, H., Murray, G. I., Sansom, O. J., Zanivan, S. R. & Murphy, D. J (2018). "Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress", Cancer Discov, 8, pp. 632-647.
  3. Repression of Type I Interferon pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B cells in Pancreatic Ductal Adenocarcinoma (2020). "Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu R, Whyte, D., Hedley, A., Laing, S., Upstill-Goddard, R., Shaw, R., Neidler, S., Gyuraszova, K., Nixon, C., Clark, W., Biankin, A., Carlin, L., Coffelt, S., Sansom, O. J., Morton, J. & Murphy, D. J.", Cancer Discov, 10, pp. 872-87.