Department of Biotechnology | Indian Institute Of Technology Madras , Chennai
team

Nitish R Mahapatra

Professor

Ph.D., Indian Institute of Chemical Biology

M.Sc., University of Calcutta

Block 1, BT 504

044 2257 4128

nmahapatra[at]iitm[.]ac[.]in

Lab: Block 1, BT 515

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  • Molecular genetics of cardiovascular and metabolic diseases
  • Mechanisms of cholesterol homeostasis
  • Catecholamine-regulatory pathways
  • Discovery of novel biomarkers for cardiometabolic disorders
  • Receptor-peptide interactions

  1. Sahu BS, Mohan J, Sahu G, Singh PK, Sonawane PJ, Sasi BK, Allu PKR, Maji SK, Bera AK, Senapati S, Mahapatra NR (2012). "Molecular interactions of the physiological anti-hypertensive peptide catestatin with the neuronal nicotinic acetylcholine receptor", J Cell Sci, 125, pp. 2323-2337, DOI: 10.1242/jcs.103176.
  2. Sasi BK, Sonawane PJ, Gupta V, Sahu BS, Mahapatra NR (2014). "Coordinated transcriptional regulation of Hspa1a gene by multiple transcription factors: crucial roles for HSF-1, NF-Y, NF-κB and CREB", J Mol Biol, 426, pp. 116-135, DOI: 10.1016/j.jmb.2013.09.008 .
  3. Kalyani A, Sonawane PJ, Khan AA, Subramanian L, Ehret GB, Mullasari AS, Mahapatra NR (2015). "Post-transcriptional Regulation of Renalase Gene by miR-29 and miR-146 MicroRNAs: Implications for Cardio-metabolic Disorders", J Mol Biol, 427, pp. 2629–2646, DOI: 10.1016/j.jmb.2015.07.003 .
  4. Subramanian L, Khan AA, Allu PKR, Kiranmayi M, Sahu BS, Sharma S, Khullar M, Mullasari AS, Mahapatra NR (2017). "A haplotype variant of the human chromogranin A gene (CHGA) promoter increases CHGA expression and the risk for cardiometabolic disorders", J Biol Chem, 292, pp. 13970-13985, DOI: 10.1074/jbc.m117.778134 .
  5. Kiranmayi M, Chirasani VR, Allu PK, Subramanian L, Martelli EE, Sahu BS, Vishnuprabu D, Kumaragurubaran R, Sharma S, Bodhini D, Dixit M, Munirajan AK, Khullar M, Radha V, Mohan V, Mullasari AS, Naga Prasad SV, Senapati S, Mahapatra NR (2016). "Catestatin Gly364Ser variant alters systemic blood pressure and the risk for hypertension in human populations via endothelial nitric oxide pathway", Hypertension , 68, pp. 334-347, DOI: 10.1161/HYPERTENSIONAHA.116.06568 .
  6. Subramanian L, Maghajothi S, Singh M, Kesh K, Kalyani A, Sharma S, Khullar M, Victor SM, Swarnakar S, Asthana S, Mullasari AS, Mahapatra NR ( 2019). "A Common Tag Nucleotide Variant in MMP7 Promoter Increases Risk for Hypertension via Enhanced Interactions With CREB (Cyclic AMP Response Element-Binding Protein) Transcription Factor", Hypertension, 74, pp. 1448-1459, DOI: 10.1161/HYPERTENSIONAHA.119.12960 .
  7. Allu PK, Kiranmayi M, Mukherjee SD, Chirasani VR, Garg R, Vishnuprabu D, Ravi S, Subramanian L, Sahu BS, Iyer DR, Maghajothi S, Sharma S, Ravi MS, Khullar M, Munirajan AK, Gayen JR, Senapati S, Mullasari AS, Mohan V, Radha V, Naga Prasad SV, Mahapatra NR (2022). "Functional Gly297Ser Variant of the Physiological Dysglycemic Peptide Pancreastatin Is a Novel Risk Factor for Cardiometabolic Disorders", Diabetes, 71, pp. 538–553, DOI: 10.2337/db21-0289.
  8. Iyer DR, Arige V, Ananthamohan K, Sundaramurthy V, Tokinoya K, Aoki K, Kurtz CL, Sethupathy P, Takekoshi K, Mahapatra NR. (2023). "Cyclic-AMP response element binding protein (CREB) and microRNA miR-29b regulate renalase gene expression under catecholamine excess conditions", Life Sci. , 328, pp. 121859, DOI: 10.1016/j.lfs.2023.121859.
  9. Iyer DR, Venkatraman J, Tanguy E, Vitale N, Mahapatra NR (2023). "Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis. ", Cell Mol Life Sci, 80, pp. 271, DOI: 10.1007/s00018-023-04908-3.