Department of Biotechnology | Indian Institute Of Technology Madras , Chennai

1. Molecular pathogenesis of HIV/AIDS
Virus-host interaction, mechanism of HIV mediated cell cycle arrest, and role of integrase during very early steps in viral infection.
2. Regulation of nucleo-cytoplasmic transport proteins
Identification and characterization of protein nuclear and nucleolar

Krishnan, R., Murugiah, M., Lakshmi, N.P., Mahalingam, S. (2020). "Guanine nucleotide binding protein like-1 (GNL1) promotes cancer cell proliferation and survival through AKT/p21CIP1signaling cascade", Molecular Biology of the Cell, 31(26), pp. pp. 2904–2920, DOI: 10.1091/mbc.E20-04-0267.
Mahalingam, S., Peter, J., Xu, Z.,Bordoloi, Devivasha.,Ho, Michelle.,Kalyanaraman, Vaniambadi S.., Srinivasan, A., Muthumani, K. (2021). "Landscape of humoral immune responses against SARS-CoV-2 in patients with COVID-19 disease and the value of antibody testing", Heliyon , 7(4), pp. e06836, DOI: 10.1016/j.heliyon.2021.e06836.
Lakshmi Ch, N.P., Sivagnanam, A., Raja, S., Mahalingam, S. (2021). "Molecular basis for RASSF10/NPM/RNF2 feedback cascade-mediated regulation of gastric cancer cell proliferation", Journal of Biological Chemistry , 297(2), pp. 100935, DOI: 10.1016/j.jbc.2021.100935.
Mirkale, K., Jain, S.K., Oviya, T.S., Mahalingam, S. (2023). "Optomicrofluidic detection of cancer cells in peripheral blood via metabolic glycoengineering", Lab on a Chip, 23(24), pp. pp. 5151–5164, DOI: 10.1039/d3lc00678f.
Bhatnagar, A., Chopra, U., Raja, S.,Das, Krishanu Dey.,Mahalingam S.., Chakravortty, D., Srinivasula, S.M. (2024). "TLR-mediated aggresome-like induced structures comprise antimicrobial peptides and attenuate intracellular bacterial survival", Molecular Biology of the Cell, 35, pp. 3, DOI: 10.1091/MBC.E23-09-0347.

S Mahalingam