Department of Biotechnology | Indian Institute Of Technology Madras , Chennai
team

Sanjib Senapati

Professor & Head

Ph.D., Indian Institute of Technology Kanpur

M.Sc., University of Calcutta

Block 2, BT 215

044 2257 4122

sanjibs[at]iitm[.]ac[.]in

Lab: Block 2, BT 213

Lab: 044 2257 8900

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  • PROTEIN DYNAMICS - We focus on understanding the relationship between protein structure, function, and dynamics. Research is focused into two major sub-groups: 1) molecular modeling of enzyme-substrate / enzyme-inhibitor interactions and 2) structure-based drug discovery. Studies are performed using

  1. V.Chirasani, P.D. Revanasiddappa, S. Senapati (2016). "Structural plasticity of cholesteryl ester transfer protein assists its lipid transfer activity", J. Biol. Chem, 291, pp. 19462-19473.
  2. D. Ghoshdastidar, S. Senapati (2018). "Dehydrated DNA in B-form: Ionic liquids in rescue ", Nucleic Acids Res, 46, pp. 4344-4353.
  3. M. Ahsan, C. Pindi and S. Senapati (2020). "Electrostatics Plays a Crucial Role in HIV-1 Protease Substrate Binding, Drugs Fail to Take the Advantage", Biochemistry, 59, pp. 3316-3331.
  4. S. Bardhan, M. H. Rahman, S. Banerjee, A. P. Singh and S. Senapati (2020). "Extended H-Bonding through Protic Ionic Liquids Facilitates the Growth and Stability of Water Domains in Hydrophobic Environment", Langmuir, 36, pp. 15362-15373.
  5. C. Pindi, V.R. Chirasani, S. Senapati (2021). "Identifying crucial E-protein residues responsible for unusual stability of Zika virus envelope", Biophys. J, 120, pp. 1-14.