About Us


  • Stem cell regeneration for Tissue Engineering, Stem cell scaffolds for cardiac, liver tissue regeneration,
  • Cancer stem cell and their targeted therapeutics,
  • Biomarker and pathways studies in Fanconi anemia,
  • Construction and production of Bacterial and Humanized Immunotoxins for cancer therapeutics,
  • Monoclonal antibody production,
  • Cancer drug delivery.


  • Elected Fellow to The National Academy of Sciences (FNASc),2014
  • Elected Fellow to Association of Microbiology of India (FEMI) 2010
  • Elected Fellow to The Biotech Research Society, India (BSRI) 2015
  • Elected Fellow to Society for Applied biotechnology India 2011
  • Elected Fellow to Madras Research Foundation (MRF) 2007
  • Life time Achievement award Nature Science foundation Coimbatore TN 2018

Selected Publication

  1. 1. Santosh Gupta, Akriti Sharma, Vasantha Kumar, Vineeta Sharma, Piyush Kumar Gupta and Rama Shanker Verma (2020) Meniscal Tissue Engineering via 3D Printed PLA monolith with carbohydrate based Self-Healing Interpenetrating Network Hydrogel International Journal of Biological Macromolecules 162, 1358-1371
  2. 2. M. Jayaprakasam, S. Surapalli, R. S. Verma (2020) Targeting leukemic stem cells using humanized chimeric immunotoxin Annals of Oncology 31, Supplement 1, Page S2
  3. 3. Janani Radhakrishnan, Sudha Varadaraj, Sanat Kumar Das Akriti Sharma, and Rama Shanker Verma (2020) Organotypic Cancer Tissue Models for Drug Screening: 3D Constructs, Bioprinting and Microfluidic Chips Drug Discovery Today 25(5) 879-89
  4. 4. Piyush Kumar Gupta, Rekha Gahtori, Siva ChanderChabattula, Kavitha Govarthanan, and Rama Shanker Verma(2020) Metal-Free Semi-Aromatic Polyester: A Novel Nanomaterial for Potential Clinical Application Journal of Drug Delivery Science and Technology 56, 101582,
  5. 5. Sridevi Surapally, MadhumathiJayaprakasam andRama Verma( (2020) Curcumin augments therapeutic efficacy of TRAIL-based immunotoxins in leukemia Pharmacological Reports
  6. 6. Santosh Gupta, Akriti Sharma, Rama S Verma (2019) Polymers in Biosensor devices for cardiovascular applications Current Opinion in Biomedical Engineering.
  7. 7. Piyush K Gupta, Surya Kant Tripathi, SreenathPappuru, Shiva ChanderChabattula, Kavitha Govarthanan, Santosh Gupta, Bijesh K Biswal, Debashis Chakraborty, Rama S Verma. ( (2019). Metal-free semi-aromatic polyester as nanodrug carrier: A novel tumor-targeting drug delivery vehicle for potential clinical application. Material Science and Engineering C: Materials for Biological Application. 107,110285
  8. 8. Kavitha Govarthanan, Piyush K Gupta, Deepa Ramasamy, Pavithra Kumar, Shobana Mahadevan, Rama S Verma.( (2019). DNA methylation microarray uncovers a permissive methylome for cardiomyocyte differentiation in human mesenchymal stem cells. Genomics. 112(2):1384-1395.
  9. 9. Raj Pranap Arun, DivyaSivanesan, Bamadeb Patra, Sudha Varadaraj,Rama S Verma.( (2019). Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP. Scientific Reports, Jul 23;9(1):10684.
  10. 10. Potharaju, M., Mathavan, A., Mangaleswaran, B., Patil, S., John, R., Ghosh, S., Kalavakonda, C., Ghosh, M.,Verma, RS. (2019). Clinicopathological Analysis of HIF-1alpha and TERT on Survival Outcome in Glioblastoma Patients: A Prospective, Single Institution Study. J Cancer, 10(11), 2397– 2406.
  11. 11. Kumar, P., Kandoi, S., Misra, R., Vijayalakshmi, S., Rajagopal, K., Verma, RS. (2019). The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine. Cytokine Growth Factor Rev., 46, 1-9.
  12. 12. Gupta, P.K., Pappuru, S., Gupta, S., Patra, B., Chakraborty, D.,Verma, R. S. (2019). Self-assembled dual-drug loaded core-shell nanoparticles based on metal-free fully alternating polyester for cancer theranostics. Mater. Sci. Eng. C, 101, 448-463.
  13. 13. Sangeetha Kandoi, Praveen Kumar L, Bamadeb Patra, Prasanna Vidyasekar, DivyaSivanesan, Vijayalakshmi S, Rajagopal K, Rama Shanker Verma (2018) Evaluation of platelet lysate as a substitute for FBS in explant and enzymatic isolation methods of human umbilical cord MSCs Nature Scientific Report 8:12439
  14. 14. Shiv Kumar Viswanathan PhD, ….., Rama Shanker Verma, PhD, …..and Sakthivel Sadayappan, PhD, (2018) Co-segregation of MYBPC3Δ25bp with MYBPC3 D389V is associated with a cardiomyopathic substrate. Journal of Association Medical Association Cardiology USA (JAMA Cardiology) Jun 1;3(6):481-488.
  15. 15. Raj Pranap Arun, DivyaSivanesan, Prasanna Vidyasekar , Rama Shanker Verma (2017) TEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity. Nature Scientific Reports Jul 20;7(1):5952.
  16. 16. Antara Banerjee, Surajit Pathak, Vimala Devi S, Dharani Vasan, Ramachandran Murugesan and Rama S Verma ( (2017) Strategies for targeted drug delivery in treatment of colon cancer –current trends and future perspectives Drug Discovery Today 22(8):1224-1232
  17. 17. Jahnavi S, Arthi N, Pallavi S, Selvaraju C, Bhuvaneshwar G S, Kumary T V, Rama Verma (2017) Nanosecond Laser Ablation Enhances Cellular Infiltration in a Hybrid Tissue Scaffold Materials Science & Engineering C 77 190–201.
  18. 18. Madumathi J., Sridevi S and Rama S Verma (2017) CD25 targeted therapy of chemotherapy resistant leukemic stem cells using DR5 specific TRAIL peptide. Stem Cell Research 19:65-75
  19. 19. S Jahnavi, U Saravananb, N Arthia, G S Bhuvaneshwarc, T V Kumaryd, S Rajane, R S Verma (2017) Biological and mechanical evaluation of a Bio-Hybrid scaffold for autologous valve tissue engineering Materials Science and Engineering: C Vol 73 (1), 59–71
  20. 20. Pavithra Shyamsunder, Milan Esner, MaunishBarvalia, Yu Jun Wu, Tomáš Loja, Huat Bay Boon, Matilde E. Lleonart, Rama S Verma, Lumir Krejci, and Alex Lyakhovich (2016) ROS-mediated defective mitophagy in Fanconi anemia is dependent on mitochondrial fission Oncotarget 7, (36) 58065
  21. 21. Madhumathi J, Sridevi S and Rama S Verma (2016) Novel TNF-related apoptotic inducing ligand-based immunotoxin for therapeutic targeting of CD25 positive leukemia Targeted Oncology 11(4), 535-547.
  22. 22. Dilipbishi, Santosh Mathapati, Jayarama R. Venugopal, Soma Guhathakurta, Kotturathu M. Cherian, Rama S. Verma and Seeram Ramakrishna (2016) A Patient-inspired Ex Vivo Liver Tissue Engineering Approach with Autologous Mesenchymal Stem Cells and Hepatogenic Serum Advanced Healthcare Materials 5 (9) 1058–1070.
  23. 23. Prasanna Vidyasekar, Pavithra Shyamsunder, Rajpranap Arun, Rajalakshmi Santhakumar, Nand Kishore Kapadia, Ravi Kumar, Rama Shanker Verma . (2015) Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks PLOS ONE Aug 21;10(8):e0135958,
  24. 24. Jahnavi S., Kumary T.V., Bhuvaneshwar G.S., Natarajan T.S., and Verma R. S. (2015) Engineering of a polymer layered bio-hybrid heart valve scaffold. Materials Science and Engineering C 51:263-73.
  25. 25. Pavithra Shyamsunder, Rama S. Verma, and Alex Lyakhovich (2015) ROMO1 regulates Redox states and serves as an inducer of NF-kappa B-driven EMT factors in Fanconi anemia Cancer letters 361(1): 33-8.
  26. 26. Viswambari Devi R., Doble M., and Verma S Rama (2015) Nanomaterials for early detection of cancer biomarker with special emphasis on gold nanoparticles in immunoassays/sensors. Biosensors and Bioelectronics Jan 29; 68C: 688-698.
  27. 27. Rajalakshmi Santhakumar, Prasanna Vidyasekar, Rama Shanker Verma (2014) Cardiogel: A Nano-Matrix Scaffold with Potential Application in Cardiac Regeneration Using Mesenchymal Stem Cells PLoS ONE 9(12): e114697.
  28. 28. Dillip Kumar Bishi, Santosh Mathapati, KotturathuMammen Cherian, Soma Guhathakurta and Rama Shanker Verma (2014) In Vitro Hepatic Trans-Differentiation of Human Mesenchymal Stem Cells Using Sera from Congestive/Ischemic Liver during Cardiac Failure Plos One: 8;9(3): e92397.
  29. 29. Pavithra Shyamsunder, Kripa S Ganesh, Prasanna Vidyasekar, Sheila Mohan and Rama Shanker Verma (2013) “Identification of Novel target Genes involved in Indian Fanconi Anemia patients using microarray” Gene Dec 1;531(2):444-50
  30. 30. Pavithra Shyamsunder, Prasanna Vidyasekar, Akshay Ranjan Shukla, Sheila Mohan, and Rama Shanker Verma. (2013) Lowered Expression Levels of a Tumor Supresser Gene- Caveolin-1 Within Dysregulated Gene Networks of Fanconi Anemia Gene 25;527(2) 521–528.
  31. 31. Dillip Kumar Bishi, Santosh Mathapati, Jayarama Reddy Venugopal, Soma Guhathakurta, KotturathuMammen Cherian, Rama Shanker Verma, Seeram Ramakrishna (2013) Trans-differentiation of Human Mesenchymal Stem Cells Generates Functional Hepatospheres on Poly (L-lactic acid)-co-poly(ε-caprolactone)/collagen Nanofibrous Scaffolds Journal of Materials Chemistry B 1 32: 3871 4034.
  32. 32. SugapriyaDhanasekaran, Bijesh Biswal, VenilSumantran and Rama S Verma (2013) Augmented Sensitivity to Methotrexate by Curcumin induced overexpression of Folate Receptor in KG-1 Cells. Biochimie 95(8): 1567-73.
  33. 33. Mathapati S, Bishi DK, Guhathakurta S, Cherian KM, Venugopal J, Ramakrishna S, Verma R. S. (2013) Nanofibers-coated acellular tissue-engineered bovine pericardium supports differentiation of mesenchymal stem cells into endothelial cells for tissue engineering. Nanomedicine 9(5):623-34.
  34. 34. Mrudula Mathew, Zaineb K. C., Rama Shanker Verma (2013) GM-CSF-DFF40: A Novel Humanized Immunotoxin Induces Apoptosis in Acute Myeloid Leukemia cells Apoptosis 18 (7) 882-895.
  35. 35. Sreejit P & R. S. Verma (2013) Natural ECM as Biomaterial for Scaffold Based Cardiac Regeneration Using Adult Bone Marrow Derived Stem Cells. Stem Cell Rev and Rep 9(2); 158-71.
  36. 36. Madhumathi J and Verma R S. (2012) Therapeutic Targets and Recent Advances in Protein Immunotoxins. Current opinion in Microbiology 15, 300–309.
  37. 37. Swati Choudhary, Mrudula Mathew and Rama S. Verma (2011) Therapeutic potential of anticancer immunotoxins. Drug Discovery Today (2011), 16 (11/12), 495-503.
  38. 38. Sreejit P and R S Verma (2011) Cardiogel supports adhesion, proliferation and differentiation of stem cells with increased oxidative stress protection. European Cell and Material Journal (eCM) 21: 107 – 121.
  39. 39. Bijesh K Biswal and Rama S Verma(2009) Differential Usage of the Transport Systems for Folic acid and Methotrexate in Normal Human T-Lymphocytes and Leukemic Cells. The Journal of Biochemistry 146 (5), 693–703.
  40. 40. Mrudula Mathew andRama S. Verma (2009) Humanized Immunotoxins - A New Generation of Immunotoxins Cancer Sciences 100, (8), 1359-1365.
  41. 41. Verma R.S., Gianolla D., Schomichik W., and Emerson S. G (1998) Increased efficiency of liposime mediated transfection by volume reduction and centrifugation Biotechniques 25(1): 46-49.
  42. 42. Verma, R. S., and Antony, A. C. (1992) Immunoreactive folate binding proteins from human saliva: isolation and comparison of two distinct species. Biochem. J. 286: 707 715. Correction Biochem J 289: 927 928.
  43. 43. Verma, R. S., Gullapalli, S., and Antony, A. C. (1992) Evidence that the hydrophobicity of isolated in situ and de novo synthesized native human placental folate receptor is a function of glycosylphosphatidylinositol anchoring to membranes. J. Biol. Chem. 267:4119 4127.
  44. 44. Verma, R. S., and Antony, A.C. (1991) Kinetic analysis, isolation and characterization of hydrophilic folate binding protein released from chorionic villi cultured under serum free conditions. J. Biol. Chem. 266:12522 12535.
  45. 45. Verma, R. S., and Antony, A. C. (1991) Kinetic isolation and characterization of soluble (s) folatebinding protein (flop) released from human placental chorionic villi associated hydrophobic FBP (M FBP) in serum free culture. Clinical Research, 39(2): 205a.
  46. 46. Antony, A. C., Briddell, R. A., Brandt, J. E., Straneva, J. E., Verma, R. S., Miller, M. E., Kalasinski, L. A., and Hoffman, R. (1991) Megaloblastic hematopolesis in vitro: interaction of anti folate receptor antibodies with hematopoletic cells leads to a proliferative response independent of megaloblastic changes J. Clin. Invest. 87: 313 325.
  47. 47. Antony, A. C., and Verma, R. S. (1989) Hydrophobic erythrocyte folate binding proteins are converted to hydrophilic forms by trypsin in vitro. Biochem. Biophys. Acta. 979:62 68.
  48. 48. Antony, A. C., Bruno, E., Briddell, R., Brandt, J., Verma, R. S., and Hoffman, R. (1987) Effect of perturbation of specific folate receptor during in vitro erythropoiesis. J. Clin. Invest. 80(6): 1618 1623.
  49. 49. Antony, A. C., Kincade, S., Verma, R. S.,And Krishnan, S. R. (1987) Identification of high affinity folate binding protein in human erythrocyte membrane. J. Clin. Invest. 80:711 723.
  50. 50. Verma, R. S.,Spencer martin, I., and Van uden, N. (1987) Role of de novo protein synthesis in the inter conversion of glucose transport systems in the yeast Pichia ohmeri. Biochem. Biophys. Acta. 900:139 144.

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