About Us

The primary research of this lab is focused on Adult Stem cells for cardiac regeneration, 3-Dimensional culture conditions, the molecular basis of the bone marrow disease - Fanconi anemia, and targeted cancer therapy. Successfully completed and ongoing Projects include Defense Research & Development Organization (DRDO) projects, Department of Science & Technology (DST) projects and Department of Biotechnology (DBT) projects. Notable outcomes include the development of an in house biomaterial for the growth of bone marrow stromal cells that led to their heightened resistance towards oxidative stress and enhanced cardiomyogenic differentiation. This lab has carried out, for the first time, a whole genome expression analysis of Indian Fanconi anemia patient samples and identified target genes implicated in phenotypic symptoms. We have also reported the down regulation of a tumor suppressor gene and its implication in the cancer susceptibility of Fanconi Anemia. We have successfully developed chimeric immunotoxins specifically targeting leukemia and solid tumors. In order to improve therapeutic index and minimize toxicity, we have also developed humanized immunotoxins.

Awards and Fellows

  • Elected Fellow to the BioTech Research Society (BRSI) 2015
  • Elected Fellow to The Indian Academy of Science (FNASc) 2014
  • ABAP Senior Scientist Award, Society for Applied Biotechnology and Applied Pharmacy India- 2014
  • Elected Fellow to Association of Microbiology of India (FAMI) 2010
  • Elected Fellow to Society for Applied biotechnology 2011
  • Genomic Pioneer recognition award 2008 held at the HUGO's International Human Genome Meeting held at Hyderabad, India 2008
  • Elected Fellow to Madras Research Foundation (MRF) 2007

Featured Publication

  1. Pavithra Shyamsunder, Milan Esner, Maunish Barvalia, Yu Jun Wu, Tomáš Loja, Huat Bay Boon, Matilde E. Lleonart, Rama S Verma , Lumir Krejci, and Alex Lyakhovich (2016) ROS-mediated defective mitophagy in Fanconi anemia is dependent on mitochondrial fission Oncotarget acepted) IF 6.4

  2. Rama S Verma (2016) Breaking dogma for future therapy using stem cell - Where we have reached? Indian J Med Res 143, February 2016, pp 125-25.

  3. Madhumathi J, Sridevi S and Rama S Verma (2016) Novel TNF-related apoptotic inducing ligand based immunotoxin for therapeutic targeting of CD25 positive leukemia Targeted Oncology 11(4), 535-547 IF 4.00Dillip Kumar Bishi, SantoshMathapati, Jayarama Reddy Venugopal, Soma Guhathakurta, KotturathuMammenCherian, Rama ShankerVerma,Seeram Ramakrishna (2013) Trans-differentiation of Human Mesenchymal Stem Cells Generates Functional Hepatospheres on Poly (L-lactic acid)-co-poly(e-caprolactone)/collagen Nanofibrous Scaffolds Journal of Materials Chemistry B ( Royal Society of Chemisty) 1 3972- 3984 Read More

  4. Mrudula Mathew,Zaineb K. C., Rama ShankerVerma (2013) GM-CSF-DFF40: A Novel HumanizedImmunotoxin Induces Apoptosis in Acute Myeloid Leukemia cellsApoptosis 18 (7); Impact Factor4.77 Read More

  5. Sreejit P and R S Verma (2011)"Cardiogel supports adhesion, proliferation and differentiation of stem cells with increased oxidative stress protection" EuropianCell and Material Jourrnal (eCM)21: 107 - 121Impact Factor 9.36 Citation:3 Read More