A Gopala Krishna

A Gopala Krishna

Ph.D, University of Pune

M.Sc, Annamalai University


Office : BT 302 Block _ 1


Research Interests

  • G-Protein Coupled Receptor (GPCR) mediated signal transduction pathways

  • Mechanism of G protein activation

  • Membrane protein biochemistry

  • Protein structure-function

  • Protein folding


Complete list of publications can be found on Scopus

  1. Biophysical Reviews contribution call: an issue focus on the life and works of Prof. Har Gobind Khorana on the occasion of the 100th anniversary of the year of his birth Gopala Krishna Aradhyam et al. Biophys Rev.2022 May 23;14(3):611-612

  2. Small peptide inhibitor from the sequence of RUNX3 disrupts PAK1-RUNX3 interaction and abrogates its phosphorylation-dependent oncogenic function.Kanumuri R, Chelluboyina AK, Biswal J, Vignesh R, Pandian J, Venu A, Vaishnavi B, Leena DJ, Jeyaraman J, Ganesan K, Aradhyam GK, Venkatraman G, Rayala SK. Oncogene. 2021 Aug;40(34):5327-5341. doi: 10.1038/s41388-021-01927-x. Epub 2021 Jul 12. PMID: 34253860

  3. Critical APJ receptor residues in extracellular domains that influence effector selectivity.Ashokan A, Harisankar HS, Kameswaran M, Aradhyam GK. FEBS J. 2021 Nov;288(22):6543-6562. doi: 10.1111/febs.16048. Epub 2021 Jun 24. PMID: 34076959

  4. Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability. Vignesh R, Sj lander A, Venkatraman G, Rayala SK, Aradhyam GK. Biochem J. 2021 Jun 25;478(12):2265-2283. doi: 10.1042/BCJ20210016.

  5. Vignesh R and Aradhyam GK. (2020) A Change in Domain Cooperativity Drives the Function of Calnuc. Biochemistry. 59:2507-2517

  6. Ashokan A, Kameswaran M, AradhyamG. K(2019) Molecular determinants on extracellular loop domains that dictate interaction between –arrestin and Human APJ Receptor. FEBS Lett. 593: 634- 643

  7. Vignesh R, AradhyamG. K. (2019) Chaperoning Against Amyloid Aggregation: Monitoring In Vitro and In Vivo. Methods Mol Biol.1929:135-15

  8. Narayanasamy S,Aradhyam G. K.(2018) Differential Response to Ca2+ from Vertebrate and Invertebrate Calumenin is Governed by a Single Amino Acid Residue. Biochemistry. 57: 722-731.

  9. Narayanasamy S,Aradhyam G. K.(2018) Differential Response to Ca2+ from Vertebrate and Invertebrate Calumenin is Governed by a Single Amino Acid Residue. Biochemistry. 57: 722-731.

  10. Ashokan A, AradhyamG. K.(2017) Effective purification of recombinant peptide ligands for GPCR research. Methods Cell Biol. 142:111-118.

  11. Andhirka SK, Vignesh R, Aradhyam G. K. (2017) The nucleotide-free state of heterotrimeric G proteins a-subunit adopts a highly stable conformation. FEBS J. 284:2464-2481.

  12. Kanuru M, Aradhyam G. K (2017) Chaperone-like Activity of Calnuc Prevents Amyloid Aggregation. Biochemistry. 56:149-159.

  13. Gupta K, Pilli VS, AradhyamG. K. Left-right axis asymmetry determining human Cryptic gene is transcriptionally repressed by Snail. (2016) BMC Dev Biol.16:39.

  14. Kumar P, Ashokan A, AradhyamG. K. (2016) Apelin binding to human APJ receptor leads to biased signaling. Biochim. Biophys. Acta.1864:1748-1756.

  15. Pilli SV, Anuradha D, Manoj N, Nagesh N, Kumar RS, AradhyamG. K. (2016) Phenotypic Variations in the 22q11 Deletion Syndrome - Study in a South Indian Population. Indian J. Pediatr.83:746-747.

  16. Vijaya S S Pilli, K Gupta, Bhanu VSSP Kotha, Aradhyam G. K. (2015) Snail mediated Cripto-1 repression regulates the cell-cycle and EMT related gene changes in IMR-32 cells. FEBS Lett.589:1249-1256.

  17. Kumar P, Aradhyam G. K. (2014) Easy and efficient protocol for purification of recombinant peptides. Protein Expr. Purif.95:129-135.

  18. Singh V, Nair SP, Aradhyam G. K. (2013) Chemistry of conjugation to gold nanoparticles affects G-protein activity differently. J. Nanobiotech.11:7-15.

  19. Kanuru M, Raman R, Aradhyam G. K. (2013) Serine protease activity of calnuc: regulation by Zn2+and G proteins. J. Biol. Chem.288(3):1762-1773

  20. Ghosh A, Sonavane U, Andhirka SK, AradhyamG. K, Joshi R. (2011) Structural insights into human GPCR protein OA1: a computational perspective. J. Mol. Model.18: 2117-2133.

  21. AradhyamGK, Balivada LM, Kanuru M, Vadivel P, Vidhya BS. (2010) Calnuc: Emerging roles in calcium signaling and human diseases. IUBMB Life.62(6): 436-446. (Invited Review)

  22. Kanuru, M., Samuel, J. K., Blaivada, L. M. and Aradhyam. G. K.(2009) Ion-binding properties of Calnuc, Ca2+- versus Mg2+-Calnuc adopts additional and unusual Ca2+-binding sites upon interaction with G-protein. FEBS Journal276: 2529-2546.

  23. Sahu, S. K., Aradhyam, G. K. and Gummadi, S. N. (2008) Over-expression of recombinant phospholipid scramblase 1 in E. coliand its purification from inclusion bodies. Biotechnol. Lett.30: 2131-2137.

  24. Sahu, S.K., Gummadi, S. N., Manoj, N. and Aradhyam, G. K.(2007) Phospholipid scramblases: an overview. Arch. of Biochem. Biophys.462:103-14.