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Faculty

A Gopala Krishna

A Gopala Krishna

Ph.D, University of Pune

M.Sc, Annamalai University

Professor

agk@iitm.ac.in

Office : BT 302 Block _ 1

+91-44-2257-4112

Research Interests

  • G-Protein Coupled Receptor (GPCR) mediated signal transduction pathways

  • Mechanism of G protein activation

  • Membrane protein biochemistry

  • Protein structure-function

  • Protein folding

Publications

  1. Vignesh R and Aradhyam GK. (2020) A Change in Domain Cooperativity Drives the Function of Calnuc. Biochemistry. 59:2507-2517

  2. Ashokan A, Kameswaran M, AradhyamG. K(2019) Molecular determinants on extracellular loop domains that dictate interaction between –arrestin and Human APJ Receptor. FEBS Lett. 593: 634- 643

  3. Vignesh R, AradhyamG. K. (2019) Chaperoning Against Amyloid Aggregation: Monitoring In Vitro and In Vivo. Methods Mol Biol.1929:135-15

  4. Narayanasamy S,Aradhyam G. K.(2018) Differential Response to Ca2+ from Vertebrate and Invertebrate Calumenin is Governed by a Single Amino Acid Residue. Biochemistry. 57: 722-731.

  5. Narayanasamy S,Aradhyam G. K.(2018) Differential Response to Ca2+ from Vertebrate and Invertebrate Calumenin is Governed by a Single Amino Acid Residue. Biochemistry. 57: 722-731.

  6. Ashokan A, AradhyamG. K.(2017) Effective purification of recombinant peptide ligands for GPCR research. Methods Cell Biol. 142:111-118.

  7. Andhirka SK, Vignesh R, Aradhyam G. K. (2017) The nucleotide-free state of heterotrimeric G proteins a-subunit adopts a highly stable conformation. FEBS J. 284:2464-2481.

  8. Kanuru M, Aradhyam G. K (2017) Chaperone-like Activity of Calnuc Prevents Amyloid Aggregation. Biochemistry. 56:149-159.

  9. Gupta K, Pilli VS, AradhyamG. K. Left-right axis asymmetry determining human Cryptic gene is transcriptionally repressed by Snail. (2016) BMC Dev Biol.16:39.

  10. Kumar P, Ashokan A, AradhyamG. K. (2016) Apelin binding to human APJ receptor leads to biased signaling. Biochim. Biophys. Acta.1864:1748-1756.

  11. Pilli SV, Anuradha D, Manoj N, Nagesh N, Kumar RS, AradhyamG. K. (2016) Phenotypic Variations in the 22q11 Deletion Syndrome - Study in a South Indian Population. Indian J. Pediatr.83:746-747.

  12. Vijaya S S Pilli, K Gupta, Bhanu VSSP Kotha, Aradhyam G. K. (2015) Snail mediated Cripto-1 repression regulates the cell-cycle and EMT related gene changes in IMR-32 cells. FEBS Lett.589:1249-1256.

  13. Kumar P, Aradhyam G. K. (2014) Easy and efficient protocol for purification of recombinant peptides. Protein Expr. Purif.95:129-135.

  14. Singh V, Nair SP, Aradhyam G. K. (2013) Chemistry of conjugation to gold nanoparticles affects G-protein activity differently. J. Nanobiotech.11:7-15.

  15. Kanuru M, Raman R, Aradhyam G. K. (2013) Serine protease activity of calnuc: regulation by Zn2+and G proteins. J. Biol. Chem.288(3):1762-1773

  16. Ghosh A, Sonavane U, Andhirka SK, AradhyamG. K, Joshi R. (2011) Structural insights into human GPCR protein OA1: a computational perspective. J. Mol. Model.18: 2117-2133.

  17. AradhyamGK, Balivada LM, Kanuru M, Vadivel P, Vidhya BS. (2010) Calnuc: Emerging roles in calcium signaling and human diseases. IUBMB Life.62(6): 436-446. (Invited Review)

  18. Kanuru, M., Samuel, J. K., Blaivada, L. M. and Aradhyam. G. K.(2009) Ion-binding properties of Calnuc, Ca2+- versus Mg2+-Calnuc adopts additional and unusual Ca2+-binding sites upon interaction with G-protein. FEBS Journal276: 2529-2546.

  19. Sahu, S. K., Aradhyam, G. K. and Gummadi, S. N. (2008) Over-expression of recombinant phospholipid scramblase 1 in E. coliand its purification from inclusion bodies. Biotechnol. Lett.30: 2131-2137.

  20. Sahu, S.K., Gummadi, S. N., Manoj, N. and Aradhyam, G. K.(2007) Phospholipid scramblases: an overview. Arch. of Biochem. Biophys.462:103-14.